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Jörg U. Schmohl,Martin Felices,Felix Oh,Alexander J. Lenvik,Aaron M. Lebeau,Jayanth Panyam,Jeffrey S. Miller,Daniel A. Vallera 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4
Purpose The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform, a 16133 bispecific natural killer (NK) cell engager (BiKE), consisting of scFvs binding FcRIII (CD16) on NK cells and CD133 on carcinoma cells, was first synthesized and a modified interleukin (IL)-15 crosslinker capable of stimulating NK effector cells was introduced. Materials and Methods DNA shuffling and ligation techniques were used to assemble and synthesize the 1615133 trispecific NK cell engager (TriKE). The construct was tested for its specificity using flow cytometry, cytotoxic determinations using chromium release assays, and lytic degranulation. IL-15–mediated expansion was measured using flow-based proliferation assays. The level of interferon (IFN)- release was measured because of its importance in the anti-cancer response. Results 1615133 TriKE induced NK cell–mediated cytotoxicity and NK expansion far greater than that achieved with BiKE devoid of IL-15. The drug binding and induction of cytotoxic degranulation was CD133+ specific and the anti-cancer activity was improved by integrating the IL-15 cross linker. The NK cell–related cytokine release measured by IFN- detection was higher than that of BiKE. NK cytokine release studies showed that although the IFN- levels were elevated, they did not approach the levels achieved with IL-12/IL-18, indicating that release was not at the supraphysiologic level. Conclusion 1615133 TriKE enhances the NK cell anti-cancer activity and provides a self-sustaining mechanism via IL-15 signaling. By improving the NK cell performance, the new TriKE represents a highly active drug against drug refractory relapse mediated by CSCs.
Electrospinning composite nanofibers of polyacrylonitrile/synthetic Na-montmorillonite
Sliman Almuhamed,Magali Bonne,Nabyl Khenoussi,Jocelyne Brendle,Laurence Schacher,Be´ne´ dicte Lebeau,Dominique C. Adolphe 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-
Nonwovens of polymer/clay composite nanofibers (namely, polyacrylonitrile/Na-montmorillonite, PAN/Na-MMT) are produced by electrospinning a solution of PAN in dimethylformamide containing syntheticNa-MMT. The influence of both Na-MMT amount and applied voltage on the properties of electrospuncomposite nonwovens was studied. Scanning electron microscopy (SEM), X-ray diffraction (XRD) andthermogravimetric analysis (TGA–DTA) were used to evaluate the morphology, structure and thermalproperties of composite nanofibers. SEM observations revealed that increasing the amount of Na-MMT inthe solution or the applied voltage increases the average diameter of electrospun composite nanofibers. The prepared composite showed a higher thermal stability that the pristine PAN nanofibers. It wasproven that the ion exchange properties of Na-MMT were maintained in the obtained composite.
Eiteneer, D.,Palsson, G.K.,Nemsak, S.,Gray, A.X.,Kaiser, A.M.,Son, J.,LeBeau, J.,Conti, G.,Greer, A.A.,Keqi, A.,Rattanachata, A.,Saw, A.Y.,Bostwick, A.,Rotenberg, E.,Gullikson, E.M.,Ueda, S.,Kobayashi Elsevier Scientific Pub. Co 2016 Journal of electron spectroscopy and related pheno Vol.211 No.-
LaNiO<SUB>3</SUB> (LNO) is an intriguing member of the rare-earth nickelates in exhibiting a metal-insulator transition for a critical film thickness of about 4 unit cells [Son et al., Appl. Phys. Lett. 96, 062114 (2010)]; however, such thin films also show a transition to a metallic state in superlattices with SrTiO<SUB>3</SUB> (STO) [Son et al., Appl. Phys. Lett. 97, 202109 (2010)]. In order to better understand this transition, we have studied a strained LNO/STO superlattice with 10 repeats of [4 unit-cell LNO/3 unit-cell STO] grown on an (LaAlO<SUB>3</SUB>)<SUB>0.3</SUB>(Sr<SUB>2</SUB>AlTaO<SUB>6</SUB>)<SUB>0.7</SUB> substrate using soft x-ray standing-wave-excited angle-resolved photoemission (SWARPES), together with soft- and hard- x-ray photoemission measurements of core levels and densities-of-states valence spectra. The experimental results are compared with state-of-the-art density functional theory (DFT) calculations of band structures and densities of states. Using core-level rocking curves and x-ray optical modeling to assess the position of the standing wave, SWARPES measurements are carried out for various incidence angles and used to determine interface-specific changes in momentum-resolved electronic structure. We further show that the momentum-resolved behavior of the Ni 3d e<SUB>g</SUB> and t<SUB>2g</SUB> states near the Fermi level, as well as those at the bottom of the valence bands, is very similar to recently published SWARPES results for a related La<SUB>0.7</SUB>Sr<SUB>0.3</SUB>MnO<SUB>3</SUB>/SrTiO<SUB>3</SUB> superlattice that was studied using the same technique (Gray et al., Europhysics Letters 104, 17004 (2013)), which further validates this experimental approach and our conclusions. Our conclusions are also supported in several ways by comparison to DFT calculations for the parent materials and the superlattice, including layer-resolved density-of-states results.