Aripiprazole-induced Tardive Dyskinesia in 13 Years Old Girl Successfully Treated with Biperiden: A Case Report

Marco Lamberti,Gabriella Di Rosa,Francesca Cucinotta,Erica Pironti,Cecilia Galati,Antonella Gagliano 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3

In the last years second-generation antipsychotics are increasingly prescribed in the pediatric population for the treatment of several psychiatric disorders. Among the long term adverse effects, extrapyramidal symptoms (EPS) are less reported compared to first-generation antipsychotics. Tardive dyskinesia (TD) is a iatrogenic rare syndrome characterized by persistent slow writhing and sudden involuntary movements mainly involving the oral-buccal-lingual area with masticatory movements. We report a young girl with mood disorders accompanied by mild intellectual disability and behavioral problems who had TD after treatment with Aripiprazole, which responded to Biperiden therapy.

Static Aeroelastic Response of Wing-Structures Accounting for In-Plane Cross-Section Deformation

Varello, Alberto,Lamberti, Alessandro,Carrera, Erasmo The Korean Society for Aeronautical and Space Scie 2013 International Journal of Aeronautical and Space Sc Vol.14 No.4

In this paper, the aeroelastic static response of flexible wings with arbitrary cross-section geometry via a coupled CUF-XFLR5 approach is presented. Refined structural one-dimensional (1D) models, with a variable order of expansion for the displacement field, are developed on the basis of the Carrera Unified Formulation (CUF), taking into account cross-sectional deformability. A three-dimensional (3D) Panel Method is employed for the aerodynamic analysis, providing more accuracy with respect to the Vortex Lattice Method (VLM). A straight wing with an airfoil cross-section is modeled as a clamped beam, by means of the finite element method (FEM). Numerical results present the variation of wing aerodynamic parameters, and the equilibrium aeroelastic response is evaluated in terms of displacements and in-plane cross-section deformation. Aeroelastic coupled analyses are based on an iterative procedure, as well as a linear coupling approach for different free stream velocities. A convergent trend of displacements and aerodynamic coefficients is achieved as the structural model accuracy increases. Comparisons with 3D finite element solutions prove that an accurate description of the in-plane cross-section deformation is provided by the proposed 1D CUF model, through a significant reduction in computational cost.

Static Aeroelastic Response of Wing-Structures Accounting for In-Plane Cross-Section Deformation

Alberto Varello,Alessandro Lamberti,Erasmo Carrera 한국항공우주학회 2013 International Journal of Aeronautical and Space Sc Vol.14 No.4

In this paper, the aeroelastic static response of flexible wings with arbitrary cross-section geometry via a coupled CUFXFLR5 approach is presented. Refined structural one-dimensional (1D) models, with a variable order of expansion for the displacement field, are developed on the basis of the Carrera Unified Formulation (CUF), taking into account cross-sectional deformability. A three-dimensional (3D) Panel Method is employed for the aerodynamic analysis, providing more accuracy with respect to the Vortex Lattice Method (VLM). A straight wing with an airfoil cross-section is modeled as a clamped beam, by means of the finite element method (FEM). Numerical results present the variation of wing aerodynamic parameters, and the equilibrium aeroelastic response is evaluated in terms of displacements and in-plane cross-section deformation. Aeroelastic coupled analyses are based on an iterative procedure, as well as a linear coupling approach for different free stream velocities. A convergent trend of displacements and aerodynamic coefficients is achieved as the structural model accuracy increases. Comparisons with 3D finite element solutions prove that an accurate description of the in-plane crosssection deformation is provided by the proposed 1D CUF model, through a significant reduction in computational cost.

The SSP4: A world of deepening inequality

Calvin, Katherine,Bond-Lamberty, Ben,Clarke, Leon,Edmonds, James,Eom, Jiyong,Hartin, Corinne,Kim, Sonny,Kyle, Page,Link, Robert,Moss, Richard,McJeon, Haewon,Patel, Pralit,Smith, Steve,Waldhoff, Stepha Elsevier 2017 Global environmental change Vol.42 No.-

<P><B>Abstract</B></P> <P>Five new scenarios, or Shared Socioeconomic Pathways (SSPs), have been developed, spanning a range of challenges to mitigation and challenges to adaptation. The Shared Socioeconomic Pathway 4 (SSP4), “Inequality” or “A Road Divided,” is one of these scenarios, characterized by low challenges to mitigation and high challenges to adaptation. We describe, in quantitative terms, the SSP4 as implemented by the Global Change Assessment Model (GCAM), the marker model for this scenario. We use demographic and economic assumptions, in combination with technology and non-climate policy assumptions to develop a quantitative representation of energy, land-use and land-cover, and emissions consistent with the SSP4 narrative. The scenario is one with stark differences within and across regions. High-income regions prosper, continuing to increase their demand for energy and food. Electrification increases in these regions, with the increased generation being met by nuclear and renewables. Low-income regions, however, stagnate due to limited economic growth. Growth in total consumption is dominated by increases in population, not increases in per capita consumption. Due to failures in energy access policies, these regions continue to depend on traditional biofuels, leading to high pollutant emissions. Declining dependence on fossil fuels in all regions means that total radiative forcing absent the inclusion of mitigation or impacts only reaches 6.4Wm<SUP>−2</SUP> in 2100, making this a world with relatively low challenges to mitigation. We explore the effects of mitigation effort on the SSP4 world, finding that the imposition of a carbon price has a varied effect across regions. In particular, the SSP4 mitigation scenarios are characterized by afforestation in the high-income regions and deforestation in the low-income regions. Furthermore, we find that the SSP4 is a world with low challenges to mitigation, but only to a point due to incomplete mitigation of land-related emissions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Describes the quantification of the SSP4 storyline by the Global Change Assessment Model (GCAM), the marker model for the SSP4. </LI> <LI> Examines the implications of the SSP4 world on energy, land, emissions, and climate, with and without efforts to mitigate. </LI> <LI> Compares the GCAM SSP4 to other scenarios. </LI> </UL> </P>

Thromboprophylaxis in Abdominoplasty: Efficacy and Safety of a Complete Perioperative Protocol

Giovanni Francesco Marangi,Francesco Segreto,Igor Poccia,Stefano Campa,Daniele Tosi,Daniela Lamberti,Paolo Persichetti 대한성형외과학회 2016 Archives of Plastic Surgery Vol.43 No.4

Background Venous thromboembolism, a spectrum of diseases ranging from deep venous thrombosis to pulmonary embolism, is a major source of morbidity and mortality. The majority of cases described in plastic surgery involve abdominoplasty. Risk assessment and prophylaxis are paramount in such patients. General recommendations were recently developed, but the evidence in the literature was insufficient to prepare exhaustive guidelines regarding the medication, dosage, timing, or length of the prophylaxis. Methods A thromboprophylaxis protocol was developed for patients undergoing abdominoplasty. The protocol consisted of preoperative, intraoperative, and postoperative measures. Enoxaparin was administered as chemoprophylaxis in selected patients. The study involved 253 patients. The patients were analyzed for age, body mass index, enoxaparin dosage, risk factors, and complications. Results Deep venous thrombosis was documented in two cases (0.8%). No pulmonary embolism occurred. Three patients (1.2%) presented mild subcutaneous abdominal hematoma within the first postoperative week that spontaneously resorbed with neither aesthetic nor functional complications. Two patients (0.8%) presented severe hematoma requiring surgical re-intervention for drainage and hemostasis revision. Statistical analysis showed no significant correlation between enoxaparin dosage and hematoma (P=0.18) or deep venous thrombosis (P=0.61). Conclusions The described thromboprophylaxis protocol proved to be effective in the prevention of thrombotic events, with an acceptable risk of hemorrhagic complications. Furthermore, it provides new evidence regarding the currently debated variables of chemoprophylaxis, namely type, dosage, timing, and length.

High Resolution Multimodal Chemical Imaging Platform for Organics and Inorganics

Kim, Songkil,Trofimov, Artem,Khanom, Fouzia,Stern, Lewis,Lamberti, William,Colby, Robert,Abmayr, David,Belianinov, Alex,Ovchinnikova, Olga S. American Chemical Society 2019 ANALYTICAL CHEMISTRY - Vol.91 No.19

<P>Chemical analysis at the nanoscale is critical to advance our understanding of materials and systems from medicine and biology to material science and computing. Macroscale-observed phenomena in these systems are in the large part driven by processes that take place at the nanoscale and are highly heterogeneous. Therefore, there is a clear need to develop a new technology that enables correlative imaging of material functionalities with nanoscale spatial and chemical resolutions that will enable us to untangle the structure-function relationship of functional materials. Therefore, here, we report on the analytical figures of merit of the newly developed correlative chemical imaging technique of helium ion microscopy coupled with secondary ion mass spectrometry (HIM-SIMS) that enables multimodal topographical/chemical imaging of organic and inorganic materials at the nanoscale. In HIM-SIMS, a focused ion beam acts as a sputtering and ionization source for chemical analysis along with simultaneous high-resolution surface imaging, providing an unprecedented level of spatial resolution for gathering chemical information on organic and inorganic materials. In this work, we demonstrate HIM-SIMS as a platform for a next-generation tool for an in situ material design and analysis capable of down to 8 nm spatial resolution chemical imaging, layered metal structure imaging in depth profiling, single graphene layer detection, and spectral analysis of metals, metal oxides, and polymers.</P> [FIG OMISSION]</BR>

Single coronary artery originating from the right sinus Valsalva and ability to work

Roberto De Rosa,Gennaro Ratti,Donato Gerardi,Carlo Tedeschi,Monica Lamberti 대한직업환경의학회 2015 대한직업환경의학회지 Vol.27 No.-

We present a case of a 56-year-old male electrician who was admitted to the hospital with atrial fibrillation, atypical chest pain and dyspnea. He gave a history that on the morning he had working for almost 4 hours carrying out various activities with considerable physical effort. After cardioversion, conventional coronary angiography revealed a suspect of single coronary vessel (SCA) arising from the right sinus of Valsalva. The patient underwent multislice computed tomography that showed a SCA arising from the right sinus Valsalva and dividing in Right Coronary Artery (RCA) and Left Main coronary artery (LM). The finding of posterior course of the LM without atherosclerotic has proved crucial for the expression of an opinion of working capacity even with limitation.

Thromboprophylaxis in Abdominoplasty: Efficacy and Safety of a Complete Perioperative Protocol

Marangi, Giovanni Francesco,Segreto, Francesco,Poccia, Igor,Campa, Stefano,Tosi, Daniele,Lamberti, Daniela,Persichetti, Paolo Korean Society of Plastic and Reconstructive Surge 2016 Archives of Plastic Surgery Vol.43 No.4

Background Venous thromboembolism, a spectrum of diseases ranging from deep venous thrombosis to pulmonary embolism, is a major source of morbidity and mortality. The majority of cases described in plastic surgery involve abdominoplasty. Risk assessment and prophylaxis are paramount in such patients. General recommendations were recently developed, but the evidence in the literature was insufficient to prepare exhaustive guidelines regarding the medication, dosage, timing, or length of the prophylaxis. Methods A thromboprophylaxis protocol was developed for patients undergoing abdominoplasty. The protocol consisted of preoperative, intraoperative, and postoperative measures. Enoxaparin was administered as chemoprophylaxis in selected patients. The study involved 253 patients. The patients were analyzed for age, body mass index, enoxaparin dosage, risk factors, and complications. Results Deep venous thrombosis was documented in two cases (0.8%). No pulmonary embolism occurred. Three patients (1.2%) presented mild subcutaneous abdominal hematoma within the first postoperative week that spontaneously resorbed with neither aesthetic nor functional complications. Two patients (0.8%) presented severe hematoma requiring surgical re-intervention for drainage and hemostasis revision. Statistical analysis showed no significant correlation between enoxaparin dosage and hematoma (P=0.18) or deep venous thrombosis (P=0.61). Conclusions The described thromboprophylaxis protocol proved to be effective in the prevention of thrombotic events, with an acceptable risk of hemorrhagic complications. Furthermore, it provides new evidence regarding the currently debated variables of chemoprophylaxis, namely type, dosage, timing, and length.

Evaluation of refined theories for multilayered shells via Axiomatic/Asymptotic method

Daoud S. Mashat,E. Carrera,Ashraf M. Zenkour,Sadah A. Al Khateeb,A. Lamberti 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.11

This paper is devoted to refined shell theories for the analysis of isotropic and laminated shells. Refined theories are built by assuminghigher expansion order for the displacement field in the shell thickness directions. The implementation of these theories is made accordingto the Carrera unified formulation (CUF) which makes it possible to obtain shell governing equations in terms of fundamental nucleiwhose form is independent of the chosen theory shell. Equivalent single layer and layer wise schemes are used. The axiomatic/asymptotic technique is employed to evaluate the effectiveness of each displacement variable in the adopted displacement expansion. The error introduced by each term deactivation is evaluated with respect to a reference solution and according to a given error criterion; ifthe error computed does not exceed an a priori defined threshold the term is considered as not relevant and discarded. In this way it ispossible to construct reduced models for each stress/displacement component. Attention has been restricted to closed form Navier typesolutions and simply supported orthotropic shells are considered in the numerical investigation. Analysis of the displacement variablesrelevance is performed considering the influence of the kind of material and of the geometry, specifically isotropic and laminated materialsand thick and thin shells. “Best”' reduced models are proposed and related distributions are discussed.