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Keun hyung Cho,Hyun-Sik Na,JooYeon Jhun,Jiyoung Kim,Seung Yoon Lee,Jeong soo Lee,In Gyu Um,Seok Jung Kim,Mi-La Cho 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Osteoarthritis (OA) is a disease that reduces quality of life due to pain caused by persistent joint destruction. In addition, as a representative chronic disease, it causes inflammation and affects immunity, and it is one of the diseases that is difficult to cure, so treatment and improvement methods are urgently needed. In a previous study, we published that LA-1 improves osteoarthritis and has cartilage protection by controlling inflammation. However, it was not known how LA-1 improves osteoarthritis in the body. So in this study, it was confirmed that the administration of LA-1 to the MIA-induced OA rat model reduces the pain threshold, protects cartilage, and regulates inflammation markers in the articular synovium. Additionally, collecting and analyzing the feces of the disease model, it affected the gastrointestinal system and improved the environment of the microbiome. Interestingly, by providing LA-1, it was confirmed that the diversity and abundance of microbiome in the intestine were changed, and that the bacteria that produced SCFAs increased. In addition, daily supply of butyrate, one of the SCFAs produced by certain bacteria, triggers autophagy activation and tends to decrease necroptosis. This suggests that systemic immunity as well as OA is regulated according to changes in the intestinal microbial community, and that activation of autophagy can indirectly reduce abnormal cell death. In addition, assuming that osteoarthritis is a chronic degenerative disease, cell analysis was performed using splenocyte and blood assuming that the immune system is deteriorated. As a result, both splenocytes and PBMCs confirmed that regulatory T cells increased and Th17 cells decreased. In summary, providing LA-1 leads to increased production of SCFAs by altering the microbes in the intestine. Accordingly, it is possible to suppress the progression of OA and control pain due to OA, and improve an abnormal joint environment by controlling autophagy and necroptosis.
Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion
Cho, Kyung-Ok,La, Hyen O.,Cho, Young-Jin,Sung, Ki-Wug,Kim, Seong Y. Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of neuroscience research Vol.83 No.2
<P>White matter lesions are thought to result from chronic cerebral ischemia and constitute a core pathology of subcortical vascular dementia. This rarefaction has been known to be associated with microglial activation. We investigated whether minocycline, a microglial inhibitor, attenuates the white matter damage induced by chronic cerebral hypoperfusion that is used as a model of vascular dementia. Male Wistar rats were subjected to bilateral, permanent occlusion of the common carotid arteries (BCCAO) to induce chronic cerebral hypoperfusion. Minocycline or saline was injected daily for 2 weeks after BCCAO. In the corpus callosum and the optic tract, white matter damage observed with Klüver-Barrera staining was significantly attenuated in the minocycline-treated group compared to saline-treated controls. In control rats, immunoreactivities of major basic protein (MBP), Ox-42 as a microglial marker, and matrix metalloproteinase (MMP)-2 were increased in the corpus callosum. Minocycline significantly reduced these changes. Co-expression of Ox-42 and MMP-2 was confirmed by double immunofluorescence histochemistry. Our results suggest that chronic treatment with minocycline could be protective against at least some ischemic white matter damage, and its mechanism may be related to suppressing microglial activation. © 2005 Wiley-Liss, Inc.</P>
(Book Reviews) Korean Women and Men ; Hae Joang Cho, Seoul: Moonhak Kwa Gisong-Sa, 1988
Cho, Oak La 숙명여자대학교 아세아여성문제연구소 1995 Asian Women Vol.1 No.-
Many books and papers had been written to promote women's status in Korea, since women's studies have been established in the Korea academic world. However, not many books discuss the nature of patriarchy in Korean society in general. This book is one of these rare works which deals with Korean society from a feminist perspective. The author, a feminist anthropologist analyzes the power and potentiality of Korean patriarchy which still strongly affects women's life in any field. The book starts with why women's liberation is so important in the Korean context. The author emphasizes that women's low position in Korean society can be an ideal one from which to see the seriousness of social problems and to suggest productive ways to bring about radical changes in society.
Cho, Mi-La,Kang, Jung-Won,Moon, Young-Mee,Nam, Hyo-Jung,Jhun, Joo-Yeon,Heo, Seong-Beom,Jin, Hyun-Tak,Min, So-Youn,Ju, Ji-Hyeon,Park, Kyung-Su,Cho, Young-Gyu,Yoon, Chong-Hyeon,Park, Sung-Hwan,Sung, You American Association of Immunologists 2006 Journal of Immunology Vol.176 No.9
<P>IL-23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 has proinflammatory activity, inducing IL-17 secretion from activated CD4(+) T cells and stimulating the proliferation of memory CD4(+) T cells. We investigated the pathogenic role of IL-23 in CD4(+) T cells in mice lacking the IL-1R antagonist (IL-1Ra(-/-)), an animal model of spontaneous arthritis. IL-23 was strongly expressed in the inflamed joints of IL-1Ra(-/-) mice. Recombinant adenovirus expressing mouse IL-23 (rAd/mIL-23) significantly accelerated this joint inflammation and joint destruction. IL-1beta further increased the production of IL-23, which induced IL-17 production and OX40 expression in splenic CD4(+) T cells of IL-1Ra(-/-) mice. Blocking IL-23 with anti-p19 Ab abolished the IL-17 production induced by IL-1 in splenocyte cultures. The process of IL-23-induced IL-17 production in CD4(+) T cells was mediated via the activation of Jak2, PI3K/Akt, STAT3, and NF-kappaB, whereas p38 MAPK and AP-1 did not participate in the process. Our data suggest that IL-23 is a link between IL-1 and IL-17. IL-23 seems to be a central proinflammatory cytokine in the pathogenesis of this IL-1Ra(-/-) model of spontaneous arthritis. Its intracellular signaling pathway could be useful therapeutic targets in the treatment of autoimmune arthritis.</P>
Cho, Seok Goo,Min, So-Youn,Park, Min Jung,Lee, Kyung Wha,Cho, Young-Gyu,Cho, Mi-La,Chang, Hong Seok,Park, Se-Ho,Lee, Jong Wook,Min, Woo Sung,Kim, Chun Choo,Kim, Ho-Youn Wiley Subscription Services, Inc., A Wiley Company 2006 Vol.54 No.6
<B>Objective</B><P>To investigate the immunoregulatory effects of allogeneic mixed chimerism induced by T cell–depleted, nonmyeloablative bone marrow transplantation (BMT) on chronic inflammatory arthritis and autoimmunity in mice deficient in interleukin-1 receptor antagonist (IL-1Ra).</P><B>Methods</B><P>IL-1Ra<SUP>−/−</SUP> mice (H-2K<SUP>d</SUP>) were treated with antibody to asialoganglioside G<SUB>M1</SUB> (anti–natural killer cell), total body irradiation (500 cGy), and T cell–depleted, nonmyeloablative BMT derived from C57BL/6 mice (H-2K<SUP>b</SUP>). Engraftment and chimerism were evaluated in peripheral blood, lymph nodes, and spleen by multicolor flow cytometry. The severity of arthritis was evaluated by clinical scoring and histopathologic assessment. Levels of IgG1 and IgG2a subtypes of anti–type II collagen (anti-CII) antibodies were measured in serum samples. After T cells were stimulated with CII, ovalbumin, and phytohemagglutinin, T cell proliferative responses and levels of cytokine production (interferon-γ [IFNγ], tumor necrosis factor α [TNFα], interleukin-10 [IL-10], and IL-17) were assayed in culture supernatants.</P><B>Results</B><P>All IL-1Ra<SUP>−/−</SUP> mice receiving BMT showed marked improvement in arthritis within 3 weeks, as well as successful induction of mixed chimerism. These mice showed higher levels of IgG1, and lower levels of IgG2a anti-CII antibodies and weaker T cell proliferative responses than did mice in the control groups (either no treatment or conditioning alone without bone marrow rescue). In mixed chimeras, the levels of IFNγ, TNFα, and IL-17 produced from CII-stimulated T cells were significantly suppressed and IL-10 production was significantly higher as compared with controls.</P><B>Conclusion</B><P>The introduction of allogeneic mixed chimerism showed a strong immunoregulatory potential to correct established chronic inflammatory arthritis and autoimmunity originating from a dysregulated proinflammatory cytokine network.</P>
A Study on the Effects of Chewing Patterns to Occlusal Contact Points and Chewing Efficiency
Cho, Li-La,Kim, Kwang-Nam,Chang, Ik-Tae,Heo, Seong-Joo 대한 두개하악장애학회 1994 대한두개하악장애학회지 Vol.6 No.2
저작은 교합과 악운동 뿐만 아니라 근신경계, 고위 중추까지 복합적으로 관여하는 기능적 행위이다. 교합양상은 다양하게 저작 형태에 끼치며 효율에도 관여한다. 저작 형태는 다양한 모양을 가지나 두가지 전형적인 군 즉, 전방에서 관찰시 그 양상이 수직적이며 chopping 운동을 닮은 군과 저작 형태가 주로 측방으로 이루어지며 grinding을 하는 군으로 나눌 수 있다. 본 연구의 목적은 저작 형태의 차이가 교합접촉 및 저작 효율에 미치는 영향을 고찰해 보고자 하는 것이다. 하악운동궤적기록기를 이용하여 정상교합을 가진 치과대학생중 전형적인 2가지 저작 형태를 보이는 각 10명씩을 피검자로 선택하였다. 3가지 하악위 즉, 중심위, 작업측, 비작업측에서의 교합접촉을 고무형교합인기재로 기록하여 천공부의 직경이 1㎜이하이면 1점, 1~2㎜ 또는 직선상이면 2점, 2㎜이상이면 3점으로 평가하여 각 점수의 합으로 좌우 소구치 및 대구치의 접촉 지수를 측정하였다. 저작 효율을 평가하기 위해 땅콩 3g(±0.01g)을 20회 저작하게 한 후 3회 입을 헹구어 뱉게 하였다. 체눈 크기가 각 0.425, 0.60, 0.85, 2.0, 4.0인 체에 기른 후 65℃로 오븐에서 세 시간 말려 무게를 측정하고 중심크기(M_50)와 저작효율치(R)를 계산 비교하여 다음과 같은 결론을 얻었다. 1. Chopping형은 grinding형에 비해 중심위에서 더 넓은 교합접촉점을 보였다(P<0.01). 2. Grinding형은 chopping형에 비해 측방위에서 더 넓은 교합접촉점을 보였다(P<0.01). 3. Chopping형은 중심크기(M_50)과 저작효율치(R)로 비교하였을 때 더 좋은 저작 효율을 보였다(P<0.05).
Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis
Cho, Young-Gyu,Cho, Mi-La,Min, So-Youn,Kim, Ho-Youn Elsevier Science B.V., Amsterdam. 2007 Autoimmunity Reviews Vol.7 No.1
<P><B>Abstract</B></P> <P>Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.</P>
리튬브로마이드 수용액의 흡습성질을 이용한 온실 냉방 및 제습 시스템 개발
조라훈 ( La Hoon Cho ),오광철 ( Kwang Cheol Oh ),이상열 ( Sang Yeol Lee ),주상연 ( Sang Yeon Joo ),박선용 ( Sun Yong Park ),이서현 ( Seo Hyeon Lee ),정인선 ( In Seon Jeong ),이충건 ( Chung Geon Lee ),김대현 ( Dae Hyun Kim ) 한국농업기계학회 2017 한국농업기계학회 학술발표논문집 Vol.22 No.1
국내 여름철의 고온다습한 기후환경으로 인하여 온실 내부의 냉방 및 제습이 필수적인데, 온실 냉방방식 중 증발냉각 시스템이 가장 효율이 높다고 알려져 있다. 하지만 증발냉각 시스템은 건조한 기후 지역에서 발달한 방식으로, 작물의 증산작용으로 인한 온실 내부 습도 상승에 따른 문제점이 발생되어 다습한 여름철 국내 기후에는 반드시 냉각과 제습이 동시에 필요하다. 따라서 증발냉각 방식 중 Fan and Pad 방식과 리튬브로마이드 수용액을 이용한 온실 냉방 및 제습을 위한 복합시스템에 관한 연구가 진행중이다. 현재 리튬브로마이드 수용액 제습 시 발생되는 발열량과 수용액의 무게변화와 같은 수용액의 흡습성질 대한 정확한 지표가 나타나 있지 않다. 이에 연구를 진행하기에 앞서 리튬브로마이드 흡습성질에 관한 데이터 자료가 필요하다고 판단되어 기초실험을 진행하였고, 본 연구에서는 Pilot Scale의 재생 순환시스템을 통해 리튬브로마이드 수용액의 흡습성질을 이용한 재사용 방안을 제시하였고, 시스템 내에서 외부투입공기와 작동유체의 흡습성질에 의한 반응 전후 온도변화 예측 모델을 수립하였다. 따라서 본 연구를 통해 리튬브로마이드 수용액의 흡습성질을 분석하고, 이를 이용한 재생 순환 시스템에 관한 연구를 진행할 예정이다.