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박장규,김윤성,구자경 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2
The authors analized 78 patients with herpes zoster treated at Department of Dermatology, Chungnam National University Hospital from 1982 to 1985 to find out the epidemiology and clinical course. The results were as follows: 1. The annual prevalence rate of herpes zoster ranged 1.5% to 2.0%(mean 1.8%) and did not increase during 8 years from 1977 to 1984. 2. There was no sexual difference. 3. Herpes zoster was seen most frequently in the 50-59 year age group (24.4%), in July in a year (16.7%) and during summer(34.6%). 4. The dermatomic involvement of herpes zoster was most common on thoracic nerve(48.7%), and others were trigerminal nerve (28.2%), cervical nerve (14.1%), lumbar nerve(6.4%) and sacral nerve(2.6%) in order. 5. The interval of onset of subjective symptoms and vesicle appearance was 3.9 days in average. The mean duration of treatment was 13.8 days. There was a tendency that both interval and duration increased with increasing age. 6. The most common complication of herpes zoster was postherpetic neuralgia (6.4%) and others were keratoconjunctivitis(2.5%), herpes zoster with aberrant vesicles (2.5%) and recurrent herpes zoster (1.3%).
Jang, Kyung Ku,Gil, So Yeon,Lim, Jong Gyu,Choi, Sang Ho American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.11
<P>Binding to mucin is the initial step for enteropathogens to establish pathogenesis. An open reading frame, gbpA, of Vibrio vulnificus was identified and characterized in this study. Compared with wild type, the gbpA mutant was impaired in binding to mucin-agar and the mucin-secreting HT29-methotrexate cells, and the impaired mucin binding was restored by the purified GbpA provided exogenously. The gbpA mutant had attenuated virulence and ability of intestinal colonization in a mouse model, indicating that GbpA is a mucin-binding protein and essential for pathogenesis of V. vulnificus. The gbpA transcription was growth phase-dependent, reaching a maximum during the exponential phase. The Fe-S cluster regulator (IscR) and the cyclic AMP receptor protein (CRP) coactivated, whereas SmcR, a LuxR homologue, repressed gbpA. The cellular levels of IscR, CRP, and SmcR were not significantly affected by one another, indicating that the regulator proteins function cooperatively to regulate gbpA rather than sequentially in a regulatory cascade. The regulatory proteins directly bind upstream of the gbpA promoter P-gbpA. DNase I protection assays, together with the deletion analyses of P-gbpA, demonstrated that IscR binds to two specific sequences centered at -164.5 and -106, and CRP and SmcR bind specifically to the sequences centered at -68 and -45, respectively. Furthermore, gbpA was induced by exposure to H2O2, and the induction appeared to be mediated by elevated intracellular levels of IscR. Consequently, the combined results indicated that IscR, CRP, and SmcR cooperate for precise regulation of gbpA during the V. vulnificus pathogenesis.</P>
Jang, Kyung Ku,Lee, Zee-Won,Kim, Bityeoul,Jung, Young Hyun,Han, Ho Jae,Kim, Myung Hee,Kim, Byoung Sik,Choi, Sang Ho American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.41
<P>The marine bacterium Vibrio vulnificus causes food-borne diseases, which may lead to life-threatening septicemia in some individuals. Therefore, identifying virulence factors in V. vulnificus is of high priority. We performed a transcriptome analysis on V. vulnificus after infection of human intestinal HT29-methotrexate cells and found induction of plpA, encoding a putative phospholipase, VvPlpA. Bioinformatics, biochemical, and genetic analyses demonstrated that VvPlpA is a phospholipase A(2) secreted in a type II secretion system-dependent manner. Compared with the wild type, the plpA mutant exhibited reduced mortality, systemic infection, and inflammation in mice as well as low cytotoxicity toward the human epithelial INT-407 cells. Moreover, plpA mutation attenuated the release of actin and cytosolic cyclophilin A from INT-407 cells, indicating that VvPlpA is a virulence factor essential for causing lysis and necrotic death of the epithelial cells. plpA transcription was growth phase-dependent, reaching maximum levels during the early stationary phase. Also, transcription factor HlyU and cAMP receptor protein (CRP) mediate additive activation and host-dependent induction of plpA. Molecular biological analyses revealed that plpA expression is controlled via the promoter, P-plpA, and that HlyU and CRP directly bind to P-plpA upstream sequences. Taken together, this study demonstrated that VvPlpA is a type II secretion system-dependent secretory phospholipase A(2) regulated by HlyU and CRP and is essential for the pathogenicity of V. vulnificus.</P>
Solvent Deposition Method 를 利用한 Indomethacin 製劑의 溶出特性에 관한 硏究
구경문,장은진,한혜성 숙명여자대학교 1984 藥硏 Vol.15 No.-
In order to evaluate the pharmaceutical aspects of solvent deposition method where drug is solvent deposited on the surface of excipients, a study has been made on dissolution characteristics of indomethacin solvent deposited on Avicel^R. In a solvent deposition system, the drug to excipient ratio effect much on dissolution rates of indomethacin. The experimental results are as follows. 1. The solvent deposition system formation was confirmed by scanning electron microscope. 2. Total ammount of indomethacin dissolved from solvent deposition system in pH7.2 at 30 minutes were enhanced about 14 to 24 percentage compared with that of physical mixture. 3. Increased dissolution amount of indomethacin from the solvent deposition system in pH7.2 were observed to be alike in the system where the drug-to-excipients weight ratios were 1:3, 1:10, and 1:5. 4. Dissolution behaviors of commercial products depend on the manufactural condition and dissolution rate of 1:3 SD-IM was greater than other commercial products.
Myofascial Pain Syndrome in Patients with Cervical Vertigo
Dae Kyung Cho,현정근,Chung Ku Rhee,이성재,Yoon Young Jang 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.2
Objective To delineate the clinical manifestation of myofascial pain syndrome (MPS) around the face, neck and shoulders in patients with cervical vertigo (CV) and to determine whether treatment of MPS can improve CV. Method We evaluated 72 patients who were diagnosed with CV and 72 patients as controls who had MPS in the neck and shoulder without vertigo symptoms. Clinical evaluations for MPS were performed on all subjects, and vestibular function tests were also performed in patients with vertigo symptoms. Most patients and controls received treatments including trigger point injection, physical therapy or medication, and were then followed up. Results Seventy CV patients (97%) had MPS in the face, neck and shoulders. The distribution of trigger points in CV patients differed from that in controls, especially in the lateral neck muscles (odds ratio=0.361, p=0.019). The gender, age, symptom duration and number of trigger points were not different between CV patients and controls. 57 CV patients and 56 controls that had received treatments were followed up. Vertigo symptoms improved in 40 CV patients (70%) after treatment of MPS and pain symptoms improved in 77% of CV patients and 75% of controls after treatment. Conclusion Most CV patients had myofascial pain syndrome and the distribution of trigger points differed from that in controls. Treatment for myofascial pain syndrome could improve vertigo symptoms in CV patients, but further study is required to delineate the relationship between MPS and CV.
( Jin-kyung Kwon ),( Seung-hee Kim ),( Jong-gil Jeon ),( Youn-ku Kang ),( Kab-yeol Jang ) 한국농업기계학회 2018 바이오시스템공학 Vol.43 No.4
Purpose: Recently, an increasing number of farms have been cultivating shiitake mushrooms using a sawdust substrate and a cooler/heater. In this study, an attempt was made to develop an environmental control system using a heat pump for cultivating high-quality shiitake mushrooms. Methods: An environmental control system, consisting of an air-to-water type heat pump, a thermal storage tank, and a radiator in a variable opening chamber, was designed and fabricated. The system was also installed in the cultivation facility of a farm cultivating shiitake mushrooms so as to compare the proposed control system with a conventional environmental control system using a cooler-condensing unit and an electric hot water boiler. Results: The uniformity of the environment was analyzed through environment measurements taken at several positions inside the cultivation facility. It was determined that the developed environmental control system is able to control the variations in temperature and relative humidity to within 1% and 3%, respectively. In addition, a maximum temperature difference of 30°C (maximum of 35°C, minimum of 5°C) and a maximum relative humidity difference of 30% (maximum of 90%, minimum of 60%) can be attained within 30 min inside the cultivation facility through the cooling of the heat pump and heating of the radiator in a variable opening chamber. Thus, the developed control system can be used to cultivate high-quality shiitake mushrooms more effectively than a conventional cooler and heater. Conclusions: In comparison with a conventional environmental control system, the developed system decreased the yield of ordinary mushrooms by 65%, and increased that of high-quality mushrooms by 217%. This corresponds to a 16% increase in gross farm income. Consequently, the developed system is expected to improve the income of shiitake mushroom cultivating farms.