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Studies on N-Ethyl-N-nitrosourea Mutagenesis in BALB/c Mice
Kyu-Hyuk Cho,Jae-Woo Cho,Chang-Woo Song 한국독성학회 2008 Toxicological Research Vol.24 No.1
N-ethyl-N-nitrosoures (ENU) is effective in inducing hypermorphic mutation as well as hypomorphic and antimorphic mutations. Therefore, this mutagen is used to the production of mutant in the mice. In order to perform an effective ENU mutagenesis using BALB/cAnN mice, determination of optimal dosage and dosage regimen of ENU is necessary. And this study tried to develop a suitable screening method and searched for novel and various mutants as model animals in phenotypedriven ENU mutagenesis. We have carried out dosage regimen for mutagenizing dose of 200 ㎎/㎏ ENU in the BALB/c mice. Total screened mice were 30,133. As the results of Esaki and Cho's Phenotype Screening, we got 2,516 phenotypic and behavior abnormalities in G₁, G₂and G₃mice. One hundred thirty five G₁phenodeviants were tested for inheritance and 16 dominant mutants were discovered. Forty two recessive mutants were also found in tested 201 micropedigrees. Early-onset mutant mice included the dysmorphology of face, eye, tail, limb, skin, and foot and abnormal behavior like circling, swimming, head tossing, stiff-walking, high cholesterol level, and tremor etc. In this study we could effectively screen G₃recessive mutants. The frequent and concise early-onset screening before weaning will be available for ENU mutagenesis.
Studies on N-Ethyl-N-nitrosourea Mutagenesis in BALB/c Mice
Cho, Kyu-Hyuk,Cho, Jae-Woo,Song, Chang-Woo Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol. No.
N-ethyl-N-nitrosoures (ENU) is effective in inducing hypermorphic mutation as well as hypomorphic and antimorphic mutations. Therefore, this mutagen is used to the production of mutant in the mice. In order to perform an effective ENU mutagenesis using BALB/cAnN mice, determination of optimal dosage and dosage regimen of ENU is necessary. And this study tried to develop a suitable screening method and searched for novel and various mutants as model animals in phenotypedriven ENU mutagenesis. We have carried out dosage regimen for mutagenizing dose of 200 mg/kg ENU in the BALB/c mice. Total screened mice were 30,133. As the results of Esaki and Cho's Phenotype Screening, we got 2,516 phenotypic and behavior abnormalities in $G_1,\;G_2\;and\;G_3$ mice. One hundred thirty five $G_1$ phenodeviants were tested for inheritance and 16 dominant mutants were discovered. Forty two recessive mutants were also found in tested 201 micropedigrees. Early-onset mutant mice included the dysmorphology of face, eye, tail, limb, skin, and foot and abnormal behavior like circling, swimming, head tossing, stiff-walking, high cholesterol level, and tremor etc. In this study we could effectively screen $G_3$ recessive mutants. The frequent and concise early-onset screening before weaning will be available for ENU mutagenesis.
자동차용 컨트롤 링크 업셋 용접부의 용접성 및 피로강도 향상에 관한 유한요소 해석
조해용,권혁홍,이봉규 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6
This study is concerned with Finite Element Analysis on welded part of control link for automobile. For analysis, control link was modeled into two parts, ring and rod. Heating condition, temperature distributions and fatigue fracture strength were analyzed using "HEAT Ⅲ" and "ENDURE" module of NISA Ⅱ. Metal flow in the process of welding was simulated by DEFORM^TM 2D. The analyzed results were compared with experimental inspection. Quality of welded part was able to be improved by controlling metal flow in the process of welding by increase the friction constant of ring part. Heat transfer analysis and flow simulations were in good agreement with welding experiments.
曺圭赫 中央醫學社 1963 中央醫學 Vol.5 No.1
Peritoneal absorption of blood proteins were carried out by observing the changes in protein fractions of the remaining blood in the peritoneal cavity into which rabbit or rat blood and serum had been injected. There could be found little or no difference in the perioneal absorption of blood proteins whether the injected fluid was whole blood or serum. However, definite differences were demonstrated to exist in the absorption between homologous and heterogous blood samples. In rapid absorption of homologous bloods, albumin was more rapidly absorbed than globulin fraction, whereas in slow absorption of heterogous bloods globulin showed more rapid absnrp tion than albumin [PartⅡ] Changes in Protein Fractions and Blood Corfiuseles in the Thoracic-Lymph following Intraperitoneal Injection of Various Bloods. Peritoneal absorption into the thoracic-lymph of blood protein and corpuscles was studied by injecting whole blood into the peritoneal cavity of dog the thoracic duct of which had been cannulated, and determining time-course changes in the protein fractions and the numbers of red and white blood cells appearing in the thoracic duct. The thoracic-lymph of control dogs(no blood injected) showed no significant time-course changes in the contents of volume of flowing lymph, total protein, and individual plasma protein fractions. When the blood from the same dog (autologous blood)was injected in the poritoneal cavity, lymphatic absorption of albumin was shown to be much faster than those of globulin, and greatly increased absorption of both red and white blood cells was demonstrated with decreased percentage of lymphocytes and increased percentage of neutrophils. With homologous blood, lymphatic absorption was of lesser degree compared with autologous blood, and albumin showed slow but faster than globulin absorption. Lymphatic absorption of red and white blood cells was modorate, and change in the differential counts of white cells was slight. In contrast, heterogous bloods showed the most slow absorption, and globulin was absorbed more rapidly than albumin. Lymphatic absorption of red blood cells was greatly decreased compared with autologous and homologous blood, and the differential count showed rapid decrease of lymphocytes in early times with increased neutrophils. The monocytes showed gradual increase with time.