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김정두,박미경 대구효성가톨릭대학교 응용과학연구소 1994 응용과학연구논문집 Vol.3 No.-
This paper discusses the interface module for Micro-SEARCH as a component of Intelligent Tutoring System. Micro-SEARCH is a system which manages and operates the learning of subjects concerning nondeterministic tasks in the field of mathematics, such as Trigonometry, Logical Expression, Algebra, Integration, and Differentiation. The study aims to implement the module with the visual display functions on windows through object-oriented programming techniques, providing the users with a graphic-oriented interface. The evaluation of designed interface module showed the convenience and efficiency of the user environment for the management and operation of the system.
정환묵,박미경 대구효성가톨릭대학교 응용과학연구소 1998 응용과학연구논문집 Vol.6 No.2
Since the multiple valued logic is compare with two-valued logic, it is PC high speed processing and increasing information density greatly in logic networks. In this paper, we represent the multiple-valued that gray level necessary image process the benefit of multiple-valued logic.
Immunomodulatory Effect of Acidic Polysaccharide Fraction from Korean Red Ginseng (Panax ginseng)
Park, Kyeong-Mee,Jeong, Tae-Cheon,Kim, Young-Sook,Shin, Han-Jae,Nam, Ki-Yeul,Park, Jong-Dae The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
Effects of red ginseng acidic polysaccharides (RGAP) on immune system were studied. The proliferation of spleen cells was induced by RGAP treatment per se. Cotreatment of lipopolysaccharide $(100\;{\mu}g/ml)$ or concanavalin A $(1\;{\mu}g/ml)$ with RGAP further stimulated the spleen cell proliferation. BALB/c mice treated with RGAP showed a slight splenic hyperplasia and increased antibody forming cell response to sheep red blood cells. Flow cytometry analysis revealed an influx of macrophages in the mice treated with RGAP.
Immunomodulatory Effect of Acidic Polysaccharide Fraction from Korean Red Ginseng (Panax ginseng)
Park, Kyeong Mee,Jeong, Tae Cheon,Kim, Young Sook,Shin, Han Jae,Nam, Ki Yeul,Park, Jong Dae 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
Effects of red ginseng acidic polysaccharides(RGAP) on immune system were studied. The proliferation of spleen cells was induced by RGAP treatment per se. Cotreatment of lipopolysaccharide(100㎍/㎖) or concanavalin A(1㎍/㎖) with RGAP further stimulated the spleen cell proliferation. BALB/c mice treated with RGAP showed a slight splenic hyperplasia and increased antibody forming cell response to sheep red blood cells. Flow cytometry analysis revealed an influx of macrophages in the mice treated with RGAP.
Park, Hwa-Jin,Rhee, Man-Hee,Park, Kyeong-Mee,Nam, Ki-Yeul,Park, Ki-Hyun The Korean Society of Ginseng 1993 Journal of Ginseng Research Vol.17 No.2
Panaxadiol (PD) from Korean red ginseng C.A. Meyer did not control the concentration of cytosolic free $Ca^{2+}$ influxes by thrombin (5 $\mu$/ml). However, PD strongly inhibited the synthesis of thromboxane. $A_2$ (TX$A_2$) in the aggregation of human platelets induced by thrombin (5 $\mu$/ml). These rexults suggest that PD blocks the any Pathway transforming to TX$A_2$ from arachidonic acid (AA) which release out of plasma membrane phospholipids by $Ca^{2+}$-dependent phospholipase C or phospholipase $A_2$. It may be also concluded that PD has the antiplatelet function by inhibiting the synthesis of TX$A_2$, which known to be the potent stimulator of the aggregation of human platelet.
Park, Hwa-Jin,Park, Kyeong-Mee,Rhee, Man-Hee,Park, Ki-Hyun The Korean Society of Ginseng 1993 Journal of Ginseng Research Vol.17 No.2
Aqueous fractions from Korean red ginseng inhibited the phosphorylations of 40 KD and 20 KD polypeptides which were induced by phorbol-12-myristate-13-acetate (100 nM) in human platelets. Much more carbohydrates were contained in the aqueous fractions than proteins. An aqueous fraction extracted with methanol, mainly, consists of glycoproteins, molecular weights of which were below 18 KD. We may infer that the aqueous fraction from Korean red ginseng do antitumorous and antiplatelet functions.
Park, Kyeong Mee,Kim, Young Sook,Jeong, Tae Cheon,Joe, Cheol O.,Shin, Han Jae,Lee, You Hui,Nam, Ki Yeul,Park, Jong Dae 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
The effects of an acidic polysaccharide isolated from the ethanol-insoluble and water-soluble fraction of Panax ginseng C.A. Meyer on immunomodulating activities were investigated. A high output nitric oxide synthase (iNOS) was shown in female BALB/c mice administered intraperitoneally with the acidic polysaccharide from ginseng. Newly synthesized iNOS protein was also observed in peritoneal macrophages cultured with interferon-?? and the acidic polysaccharide. Spleen cells from acidic polysaccharide-treated mice did not proliferate in response to concanavalin A. but restored the responsiveness by the cotreatment of N^(c)-monomethy-??-arginine (NMMA) with concanavalin A. The treatment of mice with aminoguanidine, a specific iNOS inhibitor, alleviated the acidic polysaccharide-induced suppression of antibody response to sheep red blood cells. Present results suggest that the immunomodulating activities of the acidic polysaccharide were mediated by the production of nitric oxide.
Park, Kyeong-Mee,Rhee, Man-Whee,Park, Hwa-Jin The Korean Society of Ginseng 1994 Journal of Ginseng Research Vol.18 No.1
In adrenaline-stimulated human platelets, panaxadiol (PD) and panaxatriol (PT) from Panax ginseng C.A. Meyer did not inhibit the $Ca^{2+}$-innux, but inhibited the formation of thromboxane $A_2$ and the platelet aggregations. It seems that PD and PT block a pathyway interconvefing arachidonic acids (20:4) to thromboxane $A_2$ (TX $A_2$), because the amount of $Ca^{2+}$ which phospholipase C or phospholipase $A_2$ requires to liberate 20 : 4 from membrane phospholipids was increased by PD and PT. These results mean that PH and PT have an antiplatelet effect by Inhibiting the formation of TX $A_2$.
Park, Kyeong-Mee,Choi, Eunhye,Kwak, Eun-Jung,Kim, Seoyul,Park, Wonse,Jeong, Jin-Sun,Kim, Kee-Deog Korean Academy of Oral and Maxillofacial Radiology 2018 Imaging Science in Dentistry Vol.48 No.3
Purpose: The purpose of this study was to evaluate the relationship between masseter muscle thickness, facial morphology, and mandibular morphology in Korean adults using ultrasonography. Materials and Methods: Ultrasonography was used to measure the masseter muscle thickness bilaterally of 40 adults(20 males, 20 females) and was performed in the relaxed and contracted states. Facial photos and panoramic radiography were used for morphological analyses and evaluated for correlations with masseter muscle thickness. We also evaluated the correlations of age, body weight, stature, and body constitution with masseter muscle thickness. Results: In the relaxing, the masseter was $9.8{\pm}1.3mm$ in females and $11.3{\pm}1.2mm$ in males. In the contracted state, it was $12.4{\pm}1.4mm$ in females and $14.7{\pm}1.4mm$ in males. Facial photography showed that bizygomatic facial width over facial height was correlated with masseter muscle thickness in both sexes in the relaxed state, and was statistically significantly correlated with masseter muscle thickness in males in the contracted state. In panoramic radiography, correlations were found between anterior angle length and posterior angle length and masseter muscle thickness in females, and between body length and posterior angle length, between anterior angle length and body length, between ramal length and body length, and between body length and condyle length in males. Conclusion: Masseter muscle thickness was associated with facial and mandibular morphology in both sexes, and with age in males. Ultrasonography can be used effectively to measure masseter muscle thickness.
Kyeong-Mee Park,Man-Hee Rhee,Han-Jae Shin,Yong-Bum Song,Hak-Chul Hyun,Ki-Hyun Park,Hyun-Jeong Cho,Sun-A Choi,Hyo-Chan Kang,Kyoung Jin Kim,Hyeong-Soo Kim,Hee-Jin Kang,Woo-Jeong Ok,Dong-Ha Lee,Hwa-Jin P 고려인삼학회 2008 Journal of Ginseng Research Vol.32 No.2
In this study, we have investigated the effect of panaxatriol (PT) on phosphoinositides (PIS) breakdown and Ca<SUP>2+</SUP>-elevation in thrombin-induced platelet aggregation. Thrombin (5U/ml), a potent platelet agonist which activates phospholipase Cβ via protease activated receptor (PAR), hydrolyzed PIS in platelet membrane. The phosphatidylinositol 4, 5-bisphosphate (PIP₂) was hydrolyzed after 10 sec of the thrombin-stimulation, and both the phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol (PI) were brokendown after 30 sec of the thrombin-stimulation. However, PT inhibited the thrombin-stimulated hydrolysis of PIP₂, PIP, and PI. On the other hand, thrombin increased the level of phosphatidic acid (PA) which is phosphorylated from diacylglycerol (DG) generated by PIS-hydrolysis. However, PT inhibited the thrombin-increased PA level non-significantly. Thrombin increased cytosolic free Ca<SUP>2+</SUP>[Ca<SUP>2+</SUP>]i) up to 72% as compared with control (30.8±0.9 nM) in intact platelet. However, PT (100 ㎍/ml) inhibited the thrombin-elevated [Ca<SUP>2+</SUP>]i to 100%. These results suggest that PT may have a beneficial effect on platelet aggregation-mediated thrombotic disease by inhibiting thrombin-induced platelet aggregation via suppression of the [Ca<SUP>2+</SUP>]i level and PIS breakdown.