http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sthapit, Basundhara,Liou, Kwangkyung,Lee, Hei-Chan,Sohng, Jae-Kyung 한국공업화학회 2003 응용화학 Vol.7 No.1
Neocarzinostatin (NCS), one of the outstanding 9 membered cyclic enediyne antitumor natural products, is produced by S.carzinostaticus ATCC15944 and comprised of 1:1 complex of non-peptide chromophore and peptide apoperotein (NcsA).All the bioactivities sre restored into chromophore, which consists of molecularly diverse epoxybicyclo 7.3.0 dodecadienediyne core and naphthalene moiety. The aromatic moiety is glycosylated by an unusual sugar (methylated fucosamine). All three distinct parts are in protection of apoprotein. By adopting a strategy for the cloning the biosynthetic gene clusters by dTDP 4,6 dehydratase and apoprotein as probes, we have localized 130-kb region with 103 putative ORFs. Among all, the iterative type I PKS of 5.4 kb showed similarity with 6-methylsalicylic acid synthase and orsellinic acid synthase. The heterologus expression of this gene into S. lividans TK24 showed as an important PKS type I gene involved in the aromatic Naphtholic moiety biosynthesis