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RISS 인기검색어
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- 저자 : Kwang Meyung Cho (검색결과 2 건)
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Park, Kyeong Soon,Kang, Jin Hee,Sa, Keum Hee,Koo, Hee Beom,Cho, Hyun Jung,Nam, Eon Jeong,Youn, In Chan,Kim, Kwang Meyung,Kim, In San,Kwon, Ick Chan,Choi, Kui Won,Kang, Young Mo MIT Press 2012 MOLECULAR IMAGING Vol.11 No.5
<P>We demonstrated that arthritis could be visualized noninvasively using hydrophobically modified glycol chitosan nanoparticles labeled with Cy5.5 (HGC-Cy5.5) and an optical imaging system. Activated macrophages expressing Mac-1 molecules effectively phagocytosed HGC-Cy5.5, which formed spherical nanoparticles under physiologic conditions. We estimated the applicability of HGC-Cy5.5 to quantitative analysis of arthritis development and progression. Near-infrared fluorescence images, captured after HGC-Cy5.5 injection in mice with collagen-induced arthritis, showed stronger fluorescence intensity in the active arthritis group than in the nonarthritis group. According to the progression of arthritis in both collagen-induced arthritis and collagen antibody-induced arthritis models, total photon counts (TPCs) increased in parallel with the clinical arthritis index. Quantitative analysis of fluorescence after treatment with methotrexate showed a significant decrease in TPC in a dose-dependent manner. Histologic evaluation confirmed that the mechanism underlying selective accumulation of HGC-Cy5.5 within synovitis tissues included enhanced phagocytosis of the probe by Mac-1-expressing macrophages as well as enhanced permeability through leaky vessels. These results suggest that optical imaging of arthritis using HGC-Cy5.5 can provide an objective measurement of disease activity and, at the same time, therapeutic responses in rheumatoid arthritis.</P>
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수리학적 체류시간 및 암모니아성 질소 농도가 침출수의 생물학적 처리에 미치는 영향
배재호,조광명,박수영,맹성민,송기봉 ( Jae Ho Bae,Kwang Meyung Cho,Soo Young Park,Sung Min Maeng,Ki Bong Song ) 한국물환경학회 1995 한국물환경학회지 Vol.11 No.4
The treatment of leachate from solid wastes landfill is generally difficult because it contains high concentrations of organics, ammonia nitrogen and ionic materials. Experiments were conducted to characterize the leachate generated from Kimpo Landfill Site and to investigate the effects of hydraulic retention time and ammonia nitrogen concentration on the efficiency of the leachate treatment system consisted of anaerobic digestion and extended aeration processes. The leachate was characterized for three months after eighteen months of landfill operations, and CODcr, COD_(mn), BOD, TDS, and NH₄^+ -N were stable with the average values of 3,960㎎/ℓ, 920㎎/ℓ, 3,430㎎/ℓ, 14,230㎎/ℓ, and 1,090㎎/ℓ, respectively. For anaerobic digestion of the leachate, the hydraulic retention time was found to be a critical factor for the operation, and should be maintained longer than 20 days without significant changes in flow rate. The high concentrations of NH₄^+-N and ionic materials in the leachate appeared not to significantly affect the treatment efficiency. However, for the extended aeration process which receives the anaerobic digester effluent, the hydraulic retention time appeared not to affect the organic removal efficiency. Effects of the high concentrations of NH₄^+-N and ionic materials on extended aeration process were negligible over a long term, but a longer adaptation period was required with those compounds.
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