Neutrophil to Lymphocyte Ratio and Serum Biomarkers : A Potential Tool for Prediction of Clinically Relevant Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

Osman Kula,Burak Gunay,Merve Yaren Kayabas,Yener Akturk,Ezgi Kula,Banu Tutunculer,Necdet Sut,Serdar Solak 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.6

Objective : Subarachnoid hemorrhage (SAH) is a condition characterized by bleeding in the subarachnoid space, often resulting from the rupture of a cerebral aneurysm. Delayed cerebral ischemia caused by vasospasm is a significant cause of mortality and morbidity in SAH patients, and inflammatory markers such as systemic inflammatory response index (SIRI), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and derived NLR (dNLR) have shown potential in predicting clinical vasospasm and outcomes in SAH patients. This article aims to investigate the relationship between inflammatory markers and cerebral vasospasm after aneurysmatic SAH (aSAH) and evaluate the predictive value of various indices, including SIRI, SII, NLR, and dNLR, in predicting clinical vasospasm. Methods : A retrospective analysis was performed on a cohort of 96 patients who met the inclusion criteria out of a total of 139 patients admitted Trakya University Hospital with a confirmed diagnosis of aSAH between January 2013 and December 2021. Diagnostic procedures, neurological examinations, and laboratory tests were performed to assess the patients' condition. The Student’s t-test compared age variables, while the chi-square test compared categorical variables between the non-vasospasm (NVS) and vasospasm (VS) groups. Receiver operating characteristic (ROC) curve analyses were used to evaluate the diagnostic accuracy of laboratory parameters, calculating the area under the ROC curve, cut-off values, sensitivity, and specificity. A significance level of p<0.05 was considered statistically significant. Results : The study included 96 patients divided into two groups : NVS and VS. Various laboratory parameters, such as NLR, SII, and dNLR, were measured daily for 15 days, and statistically significant differences were found in NLR on 7 days, with specific cut-off values identified for each day. SII showed a significant difference on day 9, while dNLR had significant differences on days 2, 4, and 9. Graphs depicting the values of these markers for each day are provided. Conclusion : Neuroinflammatory biomarkers, when used alongside radiology and scoring scales, can aid in predicting prognosis, determining severity and treatment decisions for aSAH, and further studies with larger patient groups are needed to gain more insights.

SPLIT QUATERNIONS AND ROTATIONS IN SEMI EUCLIDEAN SPACE E⁴₂

Kula, Levent,Yayli, Yusuf Korean Mathematical Society 2007 대한수학회지 Vol.44 No.6

We review the algebraic structure of $\mathbb{H}{\sharp}$ and show that $\mathbb{H}{\sharp}$ has a scalar product that allows as to identify it with semi Euclidean ${\mathbb{E}}^4_2$. We show that a pair q and p of unit split quaternions in $\mathbb{H}{\sharp}$ determines a rotation $R_{qp}:\mathbb{H}{\sharp}{\rightarrow}\mathbb{H}{\sharp}$. Moreover, we prove that $R_{qp}$ is a product of rotations in a pair of orthogonal planes in ${\mathbb{E}}^4_2$. To do that we call upon one tool from the theory of second ordinary differential equations.

Split quaternions and rotations in semi Euclidean space $\mathbb{E}_{2}^{4}$

Levent Kula,Yusuf Yayli 대한수학회 2007 대한수학회지 Vol.44 No.6

CONDITIONS IMPLYING CONTINUITY OF MAPS

Baran, Mehmet,Kula, Muammer,Erciyes, Ayhan Korean Mathematical Society 2009 대한수학회지 Vol.46 No.4

In this paper, we generalize the notions of preserving and strongly preserving maps to arbitrary set based topological categories. Further, we obtain characterizations of each of these concepts as well as interprete analogues and generalizations of theorems of Gerlits at al [20] in the categories of filter and local filter convergence spaces.

High Optical Anisotropy Nematic Single Compounds and Mixtures

Gauza, Sebastian,Kula, Przemyslaw,Dabrowski, Roman,Sasnouski, Genadz,Lapanik, Valeri The Korean Institute of Electrical and Electronic 2012 Transactions on Electrical and Electronic Material Vol.13 No.1

We have designed, synthesized, and evaluated the physical properties of some high birefringence (${\Delta}n$) isothiocyanato biphenyl-bistolane liquid crystals. These compounds exhibit ${\Delta}n^-$ 0.4-0.7 at room temperature and wavelength $\lambda$=633 nm. Laterally substituted short alkyl chains and fluorine atom eliminate smectic phase and lower the melting temperature. The moderate melting temperature and very high clearing temperature make those compounds attractive for eutectic mixture formulation. Several mixtures based on those compounds were formulated and its physical properties evaluated.

High Optical Anisotropy Nematic Single Compounds and Mixtures

Sebastian Gauza,Przemyslaw Kula,Roman Dabrowski,Genadz Sasnouski,Valeri Lapanik 한국전기전자재료학회 2012 Transactions on Electrical and Electronic Material Vol.13 No.1

We have designed, synthesized, and evaluated the physical properties of some high birefringence (Δn) isothiocyanato biphenyl-bistolane liquid crystals. These compounds exhibit Δn~ 0.4-0.7 at room temperature and wavelength λ=633 nm. Laterally substituted short alkyl chains and fluorine atom eliminate smectic phase and lower the melting temperature. The moderate melting temperature and very high clearing temperature make those compounds attractive for eutectic mixture formulation. Several mixtures based on those compounds were formulated and its physical properties evaluated.

Conditions implying continuity of maps

Mehmet Baran,Muammer Kula,Ayhan Erciyes 대한수학회 2009 대한수학회지 Vol.46 No.4

In this paper, we generalize the notions of preserving and strongly preserving maps to arbitrary set based topological categories. Further, we obtain characterizations of each of these concepts as well as interprete analogues and generalizations of theorems of Gerlits at al [20] in the categories of filter and local filter convergence spaces. In this paper, we generalize the notions of preserving and strongly preserving maps to arbitrary set based topological categories. Further, we obtain characterizations of each of these concepts as well as interprete analogues and generalizations of theorems of Gerlits at al [20] in the categories of filter and local filter convergence spaces.

Growth performance, carcass and meat quality of lambs supplemented different vegetable oils

Renata Miltko,Malgorzata Paulina Majewska,Grzegorz Belzecki,Katarzyna Kula,Barbara Kowalik 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.6

Objective: The purpose of this study was to evaluate the effect of rapeseed and linseed oil supplementations on performance and meat quality of lambs. Methods: The experiment was conducted on 18 growing (100-day-old) lambs of 19.7±1.9 kg live weight, assigned to 3 groups of 6 animals each. Control lambs were fed meadow hay and concentrate alone. Experimental animals additionally received rapeseed or linseed oils at a dose of 50 g/d. The lambs were slaughtered at an average body weight of 35.7±0.5 kg. Results: The dressing percentage was higher in lambs fed rapeseed oil. Total saturated fatty acids (SFA) and C15:0, C16:0, C17:0, C21:0, C24:0 were lower in longissimus dorsi muscle (MLD) in lambs fed linseed oil. Supplementation of diet with linseed oil decreased concentrations of total monounsaturated fatty acids and C16:1, C17:1, C18:1 cis-9 in MLD. The concentrations of n-3 polyunsaturated fatty acids (PUFA) and C18:3 n-3, C20:5 n-3 in MLD were higher in lambs fed linseed oil than in other groups. Oils supplementation to diets resulted in increased concentration of C22:6 n-3 in MLD. The inclusion of linseed oil into the diet increased the contents of total PUFA, n-3 PUFA and C18:3 n-3, C20:5 n-3, C22:6 n-3 in semitendinosus muscle in comparison to control. A tendency towards a lower n:6/n:3 ratio in MLD was observed when lambs were supplemented linseed oil. Conclusion: The supplementation of linseed oil to diets seems to reduce the concentration of SFA and increase the concentration of n-3 PUFA. The n-6/n-3 ratio is an important nutritional factor, and its value has been favorably decreased below 2, thereby achieving an important target related to human health. Due to these changes carcass fatty acid profile was improved, and so enhanced lamb meat healthy propertie