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- 저자 : Kuchibhotla, Kishore V (검색결과 2 건)
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Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures.
Dzhala, Volodymyr I,Kuchibhotla, Kishore V,Glykys, Joseph C,Kahle, Kristopher T,Swiercz, Waldemar B,Feng, Guoping,Kuner, Thomas,Augustine, George J,Bacskai, Brian J,Staley, Kevin J The Society 2010 The Journal of neuroscience Vol.30 No.35
<P>Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic anticonvulsants such as phenobarbital. We now report that, in intact hippocampi prepared from neonatal rats and transgenic mice expressing Clomeleon, recurrent seizures progressively increase the intracellular chloride concentration ([Cl(-)](i)) assayed by Clomeleon imaging and invert the net effect of GABA(A) receptor activation from inhibition to excitation assayed by the frequency of action potentials and intracellular Ca(2+) transients. These changes correlate with increasing frequency of seizure-like events and reduction in phenobarbital efficacy. The Na(+)-K(+)-2Cl(-) (NKCC1) cotransporter blocker bumetanide inhibited seizure-induced neuronal Cl(-) accumulation and the consequent facilitation of recurrent seizures. Our results demonstrate a novel mechanism by which seizure activity leads to [Cl(-)](i) accumulation, thereby increasing the probability of subsequent seizures. This provides a potential mechanism for the early crescendo phase of neonatal seizures.</P>
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Input size independent efficient quality meshing of the interior of 2D point cloud data
Neha Singh,Tathagata Ray,Chandu Parimi,Srivastava Kuchibhotla 한국CDE학회 2019 Journal of computational design and engineering Vol.6 No.3
This paper describes a framework to generate an unstructured Delaunay mesh of a two-dimensional domain whose boundary is specified by a point cloud data (PCD). The assumption is that the PCD is sam-pled from a smooth 1-manifold without a boundary definition and is significantly dense (at least -sampled where < 1). Presently meshing of such a domain requires two explicit steps, namely the extraction of model definition from the PCD and the use of model definition to guide the unstructured mesh generation. For a densely sampled PCD, the curve reconstruction process is dependent on the size of input PCD and can become a time-consuming overhead. We propose an optimized technique that bypasses the explicit step of curve reconstruction by implicit access to the model information from a well-sampled PCD. A mesh thus generated will be optimal, as the fineness of the mesh is not dictated by the sampling of PCD, but only the geometric complexity of the underlying curve. The implementation and experiments of the proposed framework show significant improvement in expense over the tradi-tional methodology. The main contribution of this paper is the circumvention of the explicit time-consuming step of boundary computation which is a function of the PCD sampling size and a direct gen-eration of a mesh whose complexity is dictated by the geometry of the domain.
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