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Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring
Mei Hung Chi,Ching-Lin Chu,I Hui Lee,Yi-Ting Hsieh,Ko Chin Chen,Po See Chen,Yen Kuang Yang 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4
Objective: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Methods: Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Results: Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. Conclusion: The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.
Post-Acute Care as a Key Component in a Healthcare System for Older Adults
Yu-Chun Wang,Ming-Yueh Chou,Chih-Kuang Liang,Li-Ning Peng,Liang-Kung Chen,Ching-Hui Loh 대한노인병학회 2019 Annals of geriatric medicine and research Vol.23 No.2
Older adults often experience functional decline following acute medical care. This func-tional decline may lead to permanent disability, which will increase the burden on the medical and long-term care systems, families, and society as a whole. Post-acute care aims to promote the functional recovery of older adults, prevent unnecessary hospital readmission, and avoid premature admission to a long-term care facility. Research has shown that post-acute care is a cost-effective service model, with both the hospital-at-home and community hospital post-acute care models being highly effective. This paper describes the post-acute care models of the United States and the United Kingdom and uses the example of Taiwan’s highly effective post-acute care system to explain the bene-fits and importance of post-acute care. In the face of rapid demographic aging and smaller household size, a post-acute care system can lower medical costs and improve the health of older adults after hospitalization.
The DISCOVER curriculum model: Nurturing and enhancing creativity in all children
C. June Maker,Omar Muammar,Lisa Serino,Ching Chen Kuang,Ahmed Mohamed,Ugur Sak 한국교육개발원 2006 KEDI Journal of Educational Policy Vol.3 No.2
This 3‐year study was designed to assess the impact of the DISCOVER Curriculum Model on the creativity of 2983 Hispanic, Navajo, Caucasian, African American, and Yaqui Indian elementary school children as measured by the Test of Creative thinking‐Drawing Production (TCT‐DP). Teachers (108) of similar ethnicities from 4 elementary schools were observed to determine level of implementation (high, medium, low) of a constructivist‐based curriculum model incorporating Multiple Intelligences theory (Gardner, 1983), the theory of Triarchic Mind (Sternberg, 1985), research on creativity, and principles for education of gifted students. ANOVA results showed significant increases in creativity of students in middle and high implementers’ classrooms in Year 2 and significant interaction effects across all 3 years: as grade level increased, TCT‐DP scores of students in high and middle implementer classrooms while those in low implementers’ classrooms decreased. This study lends support for the use of this model, but additional research is needed.
Su Vincent Yi-Fong,Ko Szu-Wen,Chang Yuh-Lih,Chou Yueh-Ching,Lee Hsin-Chen,Yang Kuang-Yao,Chou Kun-Ta,Hsu Chia-Chen 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.3
Purpose: Current clinical guidelines are unclear regarding the association of cardiovascular medication with the risk of acute exacerbation (AE) in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). Methods: We conducted a retrospective cohort study by interrogating the claims database of Taipei Veterans General Hospital. Patients with coexistent fixed airflow limitation and asthma were enrolled as an ACO cohort between 2009 and 2017. Exposure to cardiovascular medications, including angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), non-selective beta-blockers, cardioselective beta-blockers, dihydropyridine (DHP) calcium channel blockers (CCBs), and non-DHP CCBs, in 3-month period each served as time-dependent covariates. Patients receiving a cardiovascular medication ≥ 28 cumulative daily doses were defined as respective cardiovascular medication users. Patients were followed up until December 31, 2018. The primary endpoint was severe AE, defined as hospitalization or emergency department visit for either asthma, COPD, or respiratory failure. The secondary outcome was moderate AE. Results: The final study cohort consisted of 582 ACO subjects, with a mean follow-up period of 2.98 years. After adjustment, ARB (hazard ratio [HR], 0.64, 95% confidence interval [CI], 0.44–0.93, P = 0.019), cardioselective beta-blocker (HR, 0.29, 95% CI, 0.11–0.72, P = 0.008) and DHP CCB (HR, 0.66, 95% CI, 0.45–0.97, P = 0.035) therapies were associated with lower risks of severe AE. ARB (HR, 0.42, 95% CI, 0.30–0.62, P < 0.001) and DHP CCB (HR, 0.55, 95% CI, 0.38–0.80, P = 0.002) therapies were associated with lower risks of moderate AE. Cardioselective beta-blockers, ARBs, and DHP CCBs were associated with lower risks of severe AE in frequent exacerbators. ACEI, non-selective beta-blocker, or non-DHP CCB use did not change the risk of severe AE. Conclusions: ARB, cardioselective beta-blocker, and DHP CCB therapies may lower the risk of AE in patients with ACO.