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- 검색키워드
- 저자 : Krishna M. Prabhu (검색결과 4 건)
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Deepa Kandaswamy,MuthuKumar M,Mathew Alexander,Krishna Prabhu,Mahasampath Gowri S,Srinivasa Babu Krothapalli 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.1
Objective Motor impairments related to hand function are common symptoms in patients with movement disorders, such as Parkinson’s disease (PD) and focal hand dystonia (FHD). However, hand dysfunction has not been quantitatively assessed as a clinical tool for screening patient groups from healthy controls (HCs). The aim of our study was 1) to quantitatively assess hand dysfunction in patients with PD and FHD and its usefulness as a screening tool 2) to grade disease severity in PD and FHD based on hand dysfunction. Methods The current case-control study included HCs (n = 50) and patients with known history of PD (n = 25) or FHD (n = 16). Hand function was assessed by a precision grip task while participants lifted objects of 1.3 N and 1.7 N under dry skin conditions, followed by very wet skin conditions (VWSCs). Receiver operating characteristic and summative scoring analyses were performed. Results In PD, the combination of loading phase duration and lifting phase duration at quantitative cutoffs of 0.36 and 0.74 seconds identified 21/25 patients as diseased and 49/50 subjects as HCs with 1.7 N under VWSCs. In PD, 5/21 was graded as “mild” and 16/21 as “moderate cases.” In FHD, slip force at a cutoff of 1.2 N identified 13/16 patients as diseased and 41/50 subjects as HC with 1.7 N under VWSCs, but disease severity could not be graded. Conclusion Our results demonstrate the use of precision grip task as an important clinical tool in assessment of hand dysfunction in movement disorder patients. Use of quantitative cutoffs may improve diagnostic accuracy and serve as a valuable adjunct to existing clinical assessment methods.
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Shipra Gupta,Suman B. Sharma,Usha R. Singh,Surendra K. Bansal,Krishna M. Prabhu 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Cassia auriculata traditionally has been used to treat diabetes from ancient times. The objective of the present study was to investigate the mechanism of action for the antidiabetic activity of aqueous leaf extract of C. auriculata (CLEt) in streptozotocin-induced mildly diabetic (MD) and severely diabetic (SD) rats. CLEt was orally administered to MD and SD rats at a dose of 400mg/kg once a day for 15 days. CLEt-treated MD and SD rats showed significant reduction in fasting blood glucose. Assessment of plasma insulin and C-peptide following treatment with CLEt revealed significant elevation in their levels. Administration of CLEt enhanced the activity of hepatic hexokinase and phosphofructokinase and suppressed glucose-6-phosphatase and fructose-1,6-bisphosphatase in both MD and SD rats. A significant rise in glycogen content was also observed in both liver and muscles of CLEt-fed MD and SD rats. Histopathological examination of pancreatic sections revealed increased number of islets and β-cells in CLEt-treated MD as well as SD rats. The findings of the study suggest that the antidiabetic effect of CLEt could be due to its insulinogenic action. In addition, impaired glucose homeostasis was improved by feeding the extract through amelioration in the carbohydrate metabolic pathways. Thus, the extract may exert an antidiabetic effect through pancreatic as well as extrapancreatic action.
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Maheshwaran G.,Seethalakshmi G.,Kousalya Devi V.,VenkataKrishna Lappasi Mohanram,Ramesh Prabhu M.,Krishna Kumar M.,Sudhahar S. 한국물리학회 2022 Current Applied Physics Vol.36 No.-
The fabrication of high performance supercapacitor electrodes has been greatly investigated for future high power storage applications. In this present work, chromium oxide-cobalt oxide based nanocomposite (Cr2O3–Co3O4 NC) was synthesized using the hydrothermal approach. Moreover, the cyclic voltammetry (CV) study reveals the Cr2O3–Co3O4 NC delivers a high specific capacitance of 619.4 F/g at 10 mV/s. The electrochemical impedance spectra (EIS) of Cr2O3–Co3O4 NC possess the solution resistance (Rs) and charge transfer resistance (Rct) of 0.68 Ω and 0.03 Ω respectively. The Galvanostatic charge-discharge (GCD) analysis demonstrated the prolonged charge-discharge time and good rate capability of the Cr2O3–Co3O4 NC. The cyclic stability of Cr2O3–Co3O4 NC delivers superior capacitive retention of 83% even after 2000 cycles. The asymmetric supercapacitor (ASC) device based on Cr2O3–Co3O4//AC yielded an energy density of 4.3 Wh/kg at the corresponding power density of 200 W/kg. Furthermore, the ASC delivers superior cyclic stability of 74.8% even after 1000 consecutive charge-discharge cycles.
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Suman B. Sharma,Reenu S. Tanwar,Afreena Nasir,Krishna M. Prabhu 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.4
Diabetes is accompanied by lipid abnormalities, which contribute significantly to cardiovascular morbidity and mortality in diabetic patients. We previously demonstrated the potent antihyperglycemic activity of the active principle (fraction II from Sephadex LH 20 chromatography [LH II]) isolated from ethanolic seed extract of Eugenia jambolana in diabetic rabbits. In the present study, the efficacy of LH II was evaluated for its hypolipidemic activity in alloxan-induced mildly diabetic (MD) and severely diabetic (SD) rabbits. Phytochemical investigation of LH II by various structural spectra showed the presence of saturated fatty acid, Δ5 lipid, and sterol. Oral administration of LH II (10 mg/kg of body weight) for 21 days resulted in improved glycemic control in both MD and SD rabbits. After treatment with LH II, serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, and the total cholesterol/high-density lipoprotein cholesterol ratio were significantly improved. LH II also resulted in significant (P < .001) improvement in 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and levels of total lipids and glycogen in both MD and SD rabbits. Thus, the present study demonstrates that LH II possesses potent hypolipidemic activity and efficacy in both MD and SD rabbits.
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