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Kiyohiro Yamazaki,Yuta Yoshino,Yoko Mori,Shinichiro Ochi,Taku Yoshida,Takashi Ishimaru,Shu-ichi Ueno 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3
Nasu-Hakola disease (NHD) is a rare autosomal recessive neuropsychiatric disorder characterized by bone cysts, fractures, and cognitive impairment. Two genes are responsible for the development of NHD; TYROBP and TREM2. Although it presents with typical signs and symptoms, diagnosing this disease remains difficult. This case report describes a male with NHD with no family or past history of bone fractures who was diagnosed using exome sequencing. His frontal lobe psychiatric symptoms recovered partially following treatment with sodium valproate, but not with an antipsychotic.
Clinical investigation of patients with jaw deformity with comorbidities
Kiyohiro Kasahara,Teruhide Hoshino,Kei Sugiura,Yuki Tanimoto,Masahide Koyachi,Masae Yamamoto,Keisuke Sugahara,Masayuki Takano,Akira Katakura 대한악안면성형재건외과학회 2022 Maxillofacial Plastic Reconstructive Surgery Vol.44 No.-
Background: With improvements in the safety and stability of surgeries, the number of orthognathic surgeries isincreasing. Most patients who undergo orthognathic surgeries are younger, and the number of orthognathic surgeriesfor patients with comorbidities is also increasing. We report a survey and clinical investigation of patients withcomorbidities who underwent orthognathic surgeries at our department to improve the safety of orthognathicsurgery. Results: The participants included 296 men and 712 women, with a mean age of 28 years (13?19 years, n=144;20?29 years, n=483; 30?39 years, n=236; 40?49 years, n=102; 50?59 years, n=39; ≥60 years, n=4). In total, 347patients underwent one-stage Le Fort type I osteotomy and sagittal split ramus osteotomy (SSRO), 243 underwentSSRO, 287 underwent plate removal, 126 underwent genioplasty and plate removal, and five underwent othersurgeries. In total, 529 patients had comorbidities (52%), including allergic diseases (n=220, 33%), respiratory diseases(n=107, 16%), neurologic and psychiatric diseases (n=69, 10%), gynecologic diseases (n=28, 4%), hematologicdiseases (n=27, 4%), cardiovascular diseases (n=24, 4%), digestive diseases (n=22, 3%), metabolic and endocrinediseases (n=18, 3%), spinal diseases (n=11, 2%), ophthalmologic diseases (n=11, 2%), renal and urological diseases(n=9, 1%), and other diseases (n=117, 18%). Among the patients with comorbidities, 11 with hemorrhagic diatheses(hemophilia and von Willebrand disease), arrhythmia (atrioventricular block), psychiatric disease (adjustment disorder),and metabolic disease (diabetes) required cautious perioperative management. The patient with hemophilia wasmanaged with regular low-dose recombinant factor VIII replacement therapy, and the patient with type I diabetesmellitus was administered continuous insulin infusion and sliding-scale insulin therapy; both patients had an uneventfulcourse. Conclusions: The study findings suggest that with the increase in orthognathic surgeries, oral and maxillofacialsurgeons should adequately manage cases requiring cautious perioperative control and highlight the importance ofpreoperative screening. Despite the well-established safety and postoperative stability of orthognathic surgeries, oralsurgeons should adopt appropriate additional preventive measures for patients with comorbidities.
Probabilistic analysis of buckling loads of structures via extended Koiter law
Kiyohiro Ikeda,Makoto Ohsaki,Kentaro Sudo,Toshiyuki Kitada 국제구조공학회 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.1
Initial imperfections, such as initial deflection or remaining stress, cause deterioration of buckling strength of structures. The Koiter imperfection sensitivity law has been extended to describe the mechanism of reduction for structures. The extension is twofold: (1) a number of imperfections are considered, and (2) the second order (minor) imperfections are implemented, in addition to the first order (major) imperfections considered in the Koiter law. Yet, in reality, the variation of external loads is dominant over that of imperfection. In this research, probabilistic evaluation of buckling loads against external loads subjected to probabilistic variation is conducted by extending the concept of imperfection sensitivity. A truss arch subjected to dead and live loads is considered as a numerical example. The mechanism of probabilistic variation of buckling strength of this arch is described by the proposed method, and its reliability is evaluated.
Probabilistic analysis of buckling loads of structures via extended Koiter law
Ikeda, Kiyohiro,Ohsaki, Makoto,Sudo, Kentaro,Kitada, Toshiyuki Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.1
Initial imperfections, such as initial deflection or remaining stress, cause deterioration of buckling strength of structures. The Koiter imperfection sensitivity law has been extended to describe the mechanism of reduction for structures. The extension is twofold: (1) a number of imperfections are considered, and (2) the second order (minor) imperfections are implemented, in addition to the first order (major) imperfections considered in the Koiter law. Yet, in reality, the variation of external loads is dominant over that of imperfection. In this research, probabilistic evaluation of buckling loads against external loads subjected to probabilistic variation is conducted by extending the concept of imperfection sensitivity. A truss arch subjected to dead and live loads is considered as a numerical example. The mechanism of probabilistic variation of buckling strength of this arch is described by the proposed method, and its reliability is evaluated.
Tomoo Nakagawa,Taku Kobayashi,Kiyohiro Nishikawa,Fumika Yamada,Satoshi Asai,Yukinori Sameshima,Yasuo Suzuki,Mamoru Watanabe,Toshifumi Hibi 대한장연구학회 2019 Intestinal Research Vol.17 No.4
Background/Aims: An interim analysis of post-marketing surveillance of CT-P13, an infliximab biosimilar, was performed to evaluate its safety and efficacy in Japanese patients with inflammatory bowel disease. Methods: Patients were prospectively enrolled between November 2014 and March 2017, after the launch of CT-P13 in Japan, and case report forms of patients followed for at least 4 months were analyzed as of July 2018. Results: Of 523 patients in the analysis set, 372 remained on CT-P13 therapy, while 54 (20.2%) of 267 patients with Crohn’s disease, and 97 (37.9%) of 256 patients with ulcerative colitis were withdrawn during follow-up. A total of 144 adverse drug reactions (ADRs) were reported in 106 patients (20.3%). Infusion reaction was the most frequent ADR observed in 49 patients (9.4%). Efficacy parameters decreased immediately after the start of treatment in naïve patients to anti-tumor necrosis factor-α antibody. In the patients switched from originator infliximab for nonmedical reasons, the decreased parameters due to proceeded treatment with the originator were maintained in low ranges, and the treatment continuation rate was high with low ADR incidence. In contrast, in patients switched for medical reasons such as adverse event or loss of response, the incidence of ADRs was high. However, the efficacy parameters were improved, and the treatment continuation rate was not significantly different from that of the naïve patient group. Conclusions: In this interim analysis, CT-P13 was comparable to the originator infliximab with respect to ADRs and efficacy, and is therefore considered to be a cost-efficient interchangeable biosimilar for Japanese patients with inflammatory bowel disease.