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Implementing the Recommendations of the COI Report, and Maintaining the Momentum
( Michael Kirby ) 연세대학교 법학연구원 공공거버넌스와 법센터 2017 연세 공공거버넌스와 법 Vol.8 No.2
The Centre for Australian Studies and the Korea-Australia Foundation in cooperation with the Graduate School of International Studies, Yonsei University hosted The Honourable Michael Kirby, on May 29, 2017, at Yonsei University. Michael Kirby is former Chair of the UN Commission of Inquiry on DPRK human rights and former Justice of the High Court of Australia. Under his leadership, the Commission published its “Report of the commission of inquiry on human rights in the Democratic People`s Republic of Korea”. He shares his own experiences of writing participating in the the report for the Commission of Inquiry on DPRK and features agendas for creating a brighter future in securing North Korea human rights, especially in the new era of President Moon Jae-in.
Kirby, K A,Singh, K,Michailidis, E,Marchand, B,Kodama, E N,Ashida, N,Mitsuya, H,Parniak, M A,Sarafianos, S G R. Wegmann 2011 Cellular and molecular biology Vol.57 No.1
<P>4'—Ethynyl—2—fluoro—2'—deoxyadenosine (EFdA) is the most potent inhibitor of HIV reverse transcriptase (RT). We have recently named EFdA a Translocation Defective RT Inhibitor (TDRTI) because after its incorporation in the nucleic acid it blocks DNA polymerization, primarily by preventing translocation of RT on the template/primer that has EFdA at the 3'—primer end (T/PEFdA). The sugar ring conformation of EFdA may also influence RT inhibition by a) affecting the binding of EFdA triphosphate (EFdATP) at the RT active site and/or b) by preventing proper positioning of the 3'—OH of EFdA in T/PEFdA that is required for efficient DNA synthesis. Specifically, the North (C2'—exo/C3'—endo), but not the South (C2'—endo/C3'—exo) nucleotide sugar ring conformation is required for efficient binding at the primer—binding and polymerase active sites of RT. In this study we use nuclear magnetic resonance (NMR) spectroscopy experiments to determine the sugar ring conformation of EFdA. We find that unlike adenosine nucleosides unsubstituted at the 4'—position, the sugar ring of EFdA is primarily in the North conformation. This difference in sugar ring puckering likely contributes to the more efficient incorporation of EFdATP by RT than dATP. In addition, it suggests that the 3'—OH of EFdA in T/PEFdA is not likely to prevent incorporation of additional nucleotides and thus it does not contribute to the mechanism of RT inhibition. This study provides the first insights into how structural attributes of EFdA affect its antiviral potency through interactions with its RT target.</P>
RUSSIA IN THE GORBACHEV ERA: STILL LOOKING EAST
Kirby,Stuart The Institute for Far Eastern Studies Kyungnam Uni 1986 ASIAN PERSPECTIVE Vol.10 No.2
In 1986. Mr. Gorbachev's second year in power, the prospects for his new policy have become clearer. It is timely to asses them carefully. And especially from an Asian point of view, as the discussion is largely in Western-world terms, envisaging almost exclusively the relations between the United States and the Soviet Union as those of the Superpowers that are important, the Atlantic as the derisive hemisphere. In the metaphor of the theatre, that area is the highly lighted “upstage,” other parts of the world are more darkly “backstage” in the wings; or, in sports parlance, the “outfield.” This article confiders the posture of the Soviet Union, under its new and different leader, in its implications for Asia-as the title of this journal has It, the Asian perspective. That is a very important angle. People on the shores of the Atlantic can forget that the whole northern half of Asia is held by Russia, Asians cannot . The action there is not limited to Afghanistan today; the wide “Asian Drama,” never a one-act play set just in one locality continues in all its breadth, depth and complexity. It is necessary judge on that whole background the current position and aims of the USSR and what they imply for the Asian and Pacific world.
The 4th Industrial Revolution : The Human Dimension
Dr. Kirby BARRICK 한국직업자격학회 2017 한국직업자격학회 학술대회 Vol.2017 No.10
For more than two centuries, the world has experienced massive changes that have affected how we all live and work. First came the movement of peoples from foraging to farming, from agrarian to industrial, and from rural to urban. At a faster rate of development, the second revolution made mechanical power and mass production the norm. Then less than 50 years ago, the world was introduced to digital technology, automation, personal computers, and the internet. Now we have entered the fourth industrial revolution, where such phenomena as robotics, 3D printing, and massive virtual communities have encroached upon our lives. The implications for humankind are vast. While interest abounds in figuring out new technologies, we have been reminded by Klaus Schwab that “all of these new technologies are first and foremost tools made by people for people”. An important aspect of the fourth dimension is the need for human development through vocational education and training. Curricula, credentialing, social skills development, and public-private collaboration locally and globally are critical to preparing the current and next generations of the workforce with adequate 21st century skills.