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Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer
오형주,( Ha Young Park ),( Tae Ok Kim1 ),( Chul Kyu Park ),( Hong Jun Shin ),( Hee Jung Ban ),( In Jae Oh ),( Yong Soo Kwon ),( Yu Il Kim ),( Sung Chul Lim ),( Young Chul Kim ),( Soo Hyun Kim ),( Myung G 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Progastrin-releasing peptide (proGRP) is a recently identified biomarker of small cell lung cancer (SCLC). We aimed this study for evaluating the usefulness of automated proGRP measurement for diagnosis and treatment monitoring in patients with SCLC. Methods: From January 2011 to December 2013, plasma samples were prospectively collected from 452 [213 non-small cell lung cancer (NSCLC), 104 SCLC, 135 other diseases] patients visited for tissue diagnosis and tested by two-step automated immunoassay using the ARCHITECT proGRP assay kit (Abbott Diagnostics, USA). The cutoff level of proGRP was set at 63 pg/mL. Results: The mean proGRP was higher in SCLC (1823.0 ± 2684.0 pg/mL) than in NSCLC (61.0 ± 341.7 pg/mL) and other diseases (51.5 ± 222.6 pg/mL, p<0.001). The sensitivity of proGRP was 85.7% (90/105) in SCLC and 11.8% (25/212) in NSCLC. The specificity was 90.2%, positive predictive value was 72.5%, and negative predictive value was 95.4% in SCLC. The mean proGRP was higher in extensive disease (2158.1 ± 2980.6 pg/mL) than in limited disease (901.4 ± 1216.0 pg/mL, p=0.033). Among the 39 patients with SCLC could be followed, the mean proGRP levels of 23 responders were significantly decreased after chemotherapy (from 1651.5 ± 1386.4 pg/mL to 290.0 ± 524.8 pg/mL, p<0.001), whereas those of the 16 non-responders were not. (from 572.5 ± 790.3 pg/mL to 494.4 ± 610.9 pg/mL, p=0.583). Conclusion: Plasma proGRP could be a useful biomarker of SCLC for diagnosis and treatment monitoring. And the initial level may represent the tumor extent of SCLC.
Kim, Sue Ok,Kundu, Joydeb Kumar,Shin, Young Kee,Park, Jin-Hong,Cho, Myung-Haing,Kim, Tae-Yoon,Surh, Young-Joon Nature Publishing Group 2005 Oncogene Vol.24 No.15
[6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. The present study was aimed at unraveling the molecular mechanisms underlying previously reported antitumor promoting effects of [6]-gingerol in mouse skin in vivo. One of the well-recognized molecular targets for chemoprevention is cyclooxygenase-2 (COX-2) that is abnormally upregulated in many premalignant and malignant tissues and cells. In our present study, topical application of [6]-gingerol inhibited COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Since the transcription factor nuclear factor-kappaB (NF-κB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-κB. Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-κB through suppression of IκBα degradation and p65 nuclear translocation. Phosphorylation of both IκBα and p65 was substantially blocked by [6]-gingerol. In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-κB. Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin. The p38 MAP kinase inhibitor SB203580 attenuated NF-κB activation and subsequent COX-2 induction in TPA-treated mouse skin. Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-κB signaling pathway.Oncogene (2005) 24, 2558–2567. doi:10.1038/sj.onc.1208446 Published online 14 February 2005
A Case of Congenital Factor VII Deficiency Presented with Subacute Subdural Hematoma
Kim, Min-Kyoung,Shin, Sang-Jun,Kim, Kyung-Ok,Lee, Kyung-Hee,Hyun, Myung-Soo,Cho, Hee-Soon Yeungnam University College of Medicine 2004 Yeungnam University Journal of Medicine Vol.21 No.2
제 VII 혈액응고인자는 외인계 혈액응고기전에 매우 중요한 역할을 한다. 선천성 제 VII 혈액응고인자 결핍증은 구미에서는 인구 500,000명당 한명의 발생률을 보이는 드문 질환으로 상염색체 열성으로 유전되는 것으로 알려져 있으며 국내에서의 보고는 드물다. 이에 저자들은 경막하 출혈로 입원한 환자에서 발견된 선천성 제 VII 혈액응고인자 결핍증을 경험하고 보고하는 바이다. A congenital factor VII deficiency is a rare disorder with an estimated incidence in the western contries of one in 500,000. Because factor VII is important in initiation the coagulation cascade, a factor VII deficiency can result in significant bleeding with prolongation of the prothrombin time. We present a case of a factor VII deficiency with a subdural hematoma in an 18-year-old boy whose plasma activity of factor VII was ${\leq}10%$. Previously, he did not have any symptoms, such as hemarthrosis, easy bruising or bleeding after a minor trauma. He was administered fresh frozen plasma and a trephination was performed. His sister also had 51% lower level of factor VII.
Aerial image prediction for mask defect in extreme ultraviolet lithography
Kim, Jong-Hoi,Sim, Sang-Jin,Kwon, Young-Keun,Yoo, Myung-Sul,Park, Seung-Wook,An, Il-Sin,Kim, Ok-Kyoung,Oh, Hye-Keun 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-
Simulation has been used to predict the aerial image for masks with perfect (defect free) multilayer mirror. However, in reality, defect is easily produced in extreme ultraviolet (EUV) lithography mask fabrication process because 40 Mo/Simultilayer films are stacked and each stack is made from 2 to 4 nm . Thus, it needs to be really simulated a plate substrate with defects in EUV lithography. Many electromagnetic phenomena must be considered including geometrical shadowing, light penetration into the multilayer regions of tapered mask edges, and diffraction spreading and propagation in the presence of confining boundaries. Each of these phenomena potentially leads to worse than the ideal imaging performance. The electromagnetic near and far fields are calculated for ideal plate substrate case (defect free) and for non-planar substrate case (defect) mask structures by using finite difference time domain (FDTD) and transfer matrices and then, the results will be compared. Consequently, The aerial images with defects are also predicted from mask structure.
Ok, Hye Jeong,Park, Myung Hee,Moon, Dong Ju,Kim, Jong Ho,Park, Nam Cook,Kim, Young Chul American Scientific Publishers 2015 Journal of nanoscience and nanotechnology Vol.15 No.1
<P>Catalysts were investigated with respect to catalytic activity and coke formation in combined steam and carbon dioxide reforming of methane to develop a highly active and stable catalyst for gas to liquid processes. Ni/La-X/Al2O3 (X = Co, Ce, Mo) catalysts were prepared by an impregnation method. The combined steam and carbon dioxide reforming of methane reaction were studied as a function of high pressure (20 bar) in a fixed bed reactor system. X-ray diffraction, BET surface area, and H2-temperature programmed reduction were used to observe the characteristics of the prepared catalysts. Coke formation of used catalysts was examined by scanning electron microscopy, transmission electron microscopy and the coke amount of used catalysts was measured by thermo gravimetric analysis. Catalysts with smaller particle size had a higher temperature of reduction, which had a positive effect on catalytic activity. The improvement in active site rise and dispersion and the lowest metal crystal size had an effect on catalyst activity. As a result, the Ni/La-Co/Al2O3 catalyst showed the highest activity at a reaction temperature of 800 degrees C and a reaction pressure of 20 bar.</P>
Analgesic Effect of Intrathecal Ginsenosides in a Murine Bone Cancer Pain
( Myung Ha Yoon ),( Woong Mo Kim ),( Hyung Gon Lee ),( Jeong Il Choi ),( Yeo Ok Kim ),( Ji A Song ) 대한통증학회 2010 The Korean Journal of Pain Vol.23 No.4
Background: Bone cancer pain has a disruptive effect on the cancer patient`s quality of life. Although ginsenosides have been used as traditional medicine in Eastern Medicine, the effect on bone cancer pain has not been thoroughly studied. The aim of this study was to determine whether ginsenosides may alter the bone cancer pain at the spinal level. Methods: NCTC 2472 tumor cells (2.5 × 10(5)) were injected into the femur of adult male C3H/HeJ mice to evoke bone tumor and bone cancer pain. To develop bone tumor, radiologic pictures were obtained. To assess pain, the withdrawal threshold was measured by applying a von Frey filament to the tumor cells inoculation site. The effect of intrathecal ginsenosides was investigated. Effect of ginsenosides (150, 500, 1,000 μg) was examined at 15, 30, 60, 90, 120 min after intrathecal delivery. Results: The intrafemoral injection of NCTC 2472 tumor cells induced a radiological bone tumor. The withdrawal threshold with tumor development was significantly decreased compared to the sham animals. Intrathecal ginsenosides effectively increased the withdrawal threshold in the bone cancer site. Conclusions: NCTC 2472 tumor cells injection into the mice femur caused bone tumor and bone cancer pain. Intrathecal ginsenosides attenuated the bone cancer-related pain behavior. Therefore, spinal ginsenosides may be an alternative analgesic for treating bone cancer pain. (Korean J Pain 2010; 23: 230-235)