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김소양 ( Kim So Yang ),김지훈 ( Kim Ji Hun ),김창환 ( Kim Chang Hwan ),남순우 ( Nam Sun U ),김윤정 ( Kim Yun Jeong ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),정규원 ( Jeong Gyu 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Pheochromocytoma, a catecholamine-producing tumor of the chromaffin tissue, may present with various features. Herein, we report case of 66-year-old woman with pheochromocytoma accompanying hyperamylasemia and acute abdomen. She was admitted to another hospital due to myocardial infarction 5 months ago. At that time, pheochromocytoma was suggested on the basis of hormonal studies, but she refused surgical resection. When she came to our hospital, serum amylase level was 703 U/L. Subsequent studies revealed pancreatic type isoenzyme, and elevated lipase level. After normalization of serum amylase level, she undertook laparoscopic adrenalectomy. On pathologic examination, pheochromocytoma was confirmed. There are several cases of pheochromocytoma with hyperamylasemia. In general, the source of hyperamylasemia was thought to be pulmonary endothelial cells under ischemic damage caused by potent vasoconstrictive action of circulating catecholamines. In our case, analysis of isoenzymes and serum lipase level suggest that hyperamylasemia can originate from the pancreas. Thus, pancreatitis also should be considered when serum amylase level is elevated in pheochromocytoma. (Korean J Gastroenterol 2003;42:172-175)
Effective transduction of osteogenic sarcoma cells by a baculovirus vector
Song, Sun U.,Shin, Seok-Hwan,Kim, Soon-Ki,Choi, Gwang-Seong,Kim, Woo-Chul,Lee, Moon-Hee,Kim, Sei-Joong,Kim, In-Ho,Choi, Mi-Sook,Hong, Young-Jin,Lee, Kwan-Hee Microbiology Society 2003 The Journal of general virology Vol.84 No.3
<P>Efficient gene delivery of a baculovirus-derived vector (BV-p53-lacZ) to a human osteogenic sarcoma cell line, Saos-2, was serendipitously found while evaluating the vector for gene delivery to human p53-null tumour cells in a previous study. Therefore, we investigated other human, rat and mouse osteogenic sarcoma and other types of tumour cell lines for transduction efficiency via baculovirus vectors containing a lacZ reporter gene under the control of either a cytomegalovirus or Rous sarcoma virus promoter. The expression of beta-galactosidase protein, assessed by X-Gal staining and beta-galactosidase ELISA, demonstrated an extremely high level of transduction efficiency in some osteogenic sarcoma cell lines, such as U-2OS, Saos-2 and Saos-LM2. These human osteogenic sarcoma cell lines showed levels of beta-galactosidase expression 5-40 times greater than HepG2 cells, which were previously thought to be the mammalian cells most susceptible to baculovirus-mediated gene delivery. The level of acetylated histone proteins in these tumour lines did not correlate well with the high level of reporter gene expression. These results strongly suggest that some osteogenic sarcoma cells are highly susceptible to baculovirus-mediated gene delivery and that a baculovirus-derived vector is an efficient gene delivery vehicle into human osteogenic sarcoma cells.</P>
김기진 ( Kim Gi Jin ),홍창배 ( Hong Chang Bae ),박주식 ( Park Ju Sig ),천우광 ( Cheon U Gwang ),안나영 ( An Na Yeong ),오경숙 ( O Gyeong Sug ),김상현 ( Kim Sang Hyeon ),김태호 ( Kim Tae Ho ),이인규 ( Lee In Gyu ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.3
This study investigated the detail differences on the body fat distribution, blood concentration of lipid profiles (TC,LDL-C, HDL-C, and TG), leptin, and FFA following to subtype of obesity. In the comparison between two groups by regional obesity. %fat and BMI showed the similar results between men and women, but blood concentrations of overall lipid profiles showed the differences. Men showed no significant difference of all items except of HDL-C between non-obese and obese group, but blood level of lipid profiles in women showed a significant difference between two groups. In the comparison of blood FFA and leptin concentration between non-obese and obese group, the difference showed between men and women. And women showed a significant (P<0.05) higher blood leptin level than men. Abdominal obese group (indicator: WHR) showed a higher level of blood lipid profiles with regard to CVD risk factors than the other groups. Especially. these negative effects of women showed a results as compared with men, and the population ratio of abdominal obese in women showed a higher values than men.
강-저수지 복합형 시스템내 봄 동물플랑크톤의 역동성 (낙동강, 한국): 식물플랑크톤 생체량 조절자로서의 역할
김현우 ( Kim Hyeon U ),장광현 ( Jang Gwang Hyeon ),정광석 ( Jeong Gwang Seog ),주기재 ( Ju Gi Jae ) 한국하천호수학회 2003 생태와 환경 Vol.36 No.4
During a three-year study (2000-2002), dramatic changes in the phytoplankton biomass and high transparency were repeatedly observed during mid-spring in the lower part of the Nakdong River. Rotifers(Branchonus, Keratella, Polyarthra), sharply increased (to near 20 days) and water temperature increased from 10℃ to > 20℃ toward the end of springm small cladocerans noticeably increased. Once phytoplankton biomass passed their peak stage in the min-spring, a short period (one or two weeks) of relatively low phytoplankton biomass and high Secchi transparencies occurred. Grazing by the zooplankton was highest in spring, thus, it seems that high grazing activities of zooplankton grazing regulated phytoplankton dynamics in the river. The results indicate that the role of zooplankton grazing in controlling the phytoplankton biomass becomes more important during the spring when river water is relatively stagnant.
김태훈 ( Kim Tae Hun ),정대영 ( Jeong Dae Yeong ),정우백 ( Jeong U Baeg ),손동균 ( Son Dong Gyun ),조돈현 ( Jo Don Hyeon ),정지성 ( Jeong Ji Seong ),김형근 ( Kim Hyeong Geun ),김재광 ( Kim Jae Gwang ),선희식 ( Seon Hui Sig ),강창 대한소화기학회 2004 대한소화기학회지 Vol.43 No.3
Although advances in imaging technology have allowed for earlier detection of disease, hepatocellular carcinoma is usually asymptomatic and discovered at an advanced stage with metastasis. The most common sites of metastasis include lung, peritoneum, adrenal gland, and bone, but rarely, the nasal cavity, orbit, gallbladder, and ovary can be metastatic sites. We experienced a case of metastatic hepatocellular carcinoma of the ovary in a living patient. The differential diagnosis includes hepatoid yolk sac tumor of the ovary, primary or metastatic hepatoid carcinoma and primary or metastatic oxyphil cell tumor of the ovary. To the best of our knowledge, there have been eight cases of metastatic hepatocellular carcinoma of the ovary in the English literature and only six cases discovered in living patients. This is the first report of a metastatic hepatocellular carcinoma of the ovary in Korea. (Korean J Gastroenterol 2004;43:215-218)
포스터 전시 : 상부위장관 ; 드문 임상양상을 보인 십이지장 중복낭(Duodenal Duplication Cyst) 3예
김현수 ( Kim Hyeon Su ),주광로 ( Ju Gwang Lo ),신수진 ( Sin Su Jin ),우순주 ( U Sun Ju ),박종호 ( Park Jong Ho ),신정우 ( Sin Jeong U ),방성조 ( Bang Seong Jo ),김도하 ( Kim Do Ha ),박능화 ( Park Neung Hwa ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
위장관 중복낭은 주로 소아에서 발견되는 드문 선천성 기형으로 위장관 어디에서나 발생될 수 있으나 회장 말단이 가장 흔히 발생되는 장소이며 십이지장에서 발생하는 경우는 4~12%로 주로 구부와 2부에 국한되어 발생한다. 임상양상은 장 폐색이 주된 소견이며 이외 폐쇄성 황달, 췌장염, 출혈, 및 천공 등이 드물게 나타날 수 있다. 본 증례는 성인에서 발견되고 병리학적으로 확진된 십이지장 중복낭 3예로 각각 폐쇄성 황달 및 췌장염, 재발성 췌장염, 출혈과 천
김수찬 ( Kim Su Chan ),안규중 ( An Gyu Jung ),한승경 ( Han Seung Gyeong ),김진우 ( Kim Jin U ),성경제 ( Seong Gyeong Je ),계영철 ( Gye Yeong Cheol ),김낙인 ( Kim Nag In ),조광현 ( Jo Gwang Hyeon ),김광중 ( Kim Gwang Jung ),윤재일 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9
전국의 31개 병의원에서 10개월간 피부과 내원환자 중 피부외용제에 의한 부작용을 나타낸 1257예의 사례를 수집하여 분석하였으며 다음과 같은 결과를 얻었다. 1) 외용제에 의한 부작용은 오용 및 치료지연(40%), 진균감영(29%), 세균감영(14%), 접촉피부염(9%), 여드름, 피부위축, 혈관확장 등의 순으로 그 빈도가 높았으며 스테로이드 도포에 의한 부작용은 모두 620건(49%)에 달하였다. 2) 오용의 경우 백선증을 습진으로 오진한 경우가 7 Background : The abuse, misuse, and adverse effects to topical drugs have been widespread in Korea due to lack of awareness of seriousness of drug abuse and misuse, and improper designation of prescription and non-prescription drugs. Objective : This stud