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Boric Acid로 함침된 C/C-Composit의 산화 특성에 관한 연구
김덕주,정두환,주혁종 충남대학교 공업교육연구소 1986 論文集 Vol.8 No.3
The purpose of this paper is to enhance oxidation resistance and physical strength of the C/C composites by impregnation with Broic acid. The green C/C-composites were treated at 200℃, 600℃, 800℃ and 1000℃ after 5 times impregnation with Boric acid. The results were as follow. 1) Chemical and physical bonding were observed after impregnation with Boric acid and heat treatment 2) The oxidation resistance of C/C-composites were incresed by treating preheated treatment temperature. 3) It was observed that density and inter-laminar shear strength incresed after treating Broic acid impregnation and preheated treatment temperature.
Siloxane-Polyester공중합물의 합성과 그 열적 특성에 관한 연구
姜斗煥,梁在乾,金晟範 단국대학교 1983 論文集 Vol.17 No.-
High molecular weight block copolymer having the structure [(CH_3)_2SiO]_n[O?COO?O]_m prepared from the copolymerization of chloride end blocked polydimethylsiloxane and hydroquinone p-hydroxybenzoate. Siloxane sequence was controlled by employing chloride ended polydimethylsiloxane of diffrent degrees of polymerization. As a result, copolymers ranging in composition from 16% of 58wt% siloxane sequence were synthesized and characterized by IR, NMR, DSC, and TG. Thermal properties of copolymer with 25wt% siloxane unit had the higher thermal degradation temperature, 650∼700℃ than polydimethylsiloxane which degradate at 300∼350℃, but the copolymer had poor solubility.
難燃性 軟質 Polyurethane Foam의 製造에 관한 硏究
姜斗煥,金奎權 단국대학교 대학원 1984 學術論叢 Vol.8 No.-
Falme retardant polyurethane foam was prepared by foaming mixed polyether polyol which has different OH value, such as OH No. 56,560,840, etc. with TDI, and added various retard agent to the compounds mixture. As the result of the mechanical and flammability test of the foam, tensile strength and tear resistance were decreased, and compressive strength and flame retardancy were a little increased, as the amount of polyether polyol with higher OH value was increased. The flame retardant agent such as tricresyl phosphate (TCP), Tri (βchloro ethyl) phosphate(TCEP), PHT_4-diol (PHT_4) and Sb_2O_3 was added to the compounds foaming, and the flammability and the mechanical properties of the foams were measured. As the result of the mechanical and flammability test of the foam increased the various the result of the mechanical and flammability test of the foam increased the various retardant agenciesy, the flammability resuet showed better in the order of PHT_4 TCEP, TCP, and Sb_2O_3, and the mechanical properties were similar to the result in case of the foam prepared with mixed polyether polyol having different OH value with TDI.
Kim, Ji Tae,Kim, Jong-Soo,Ko, Kwang Won,Kong, Doo-Sik,Kang, Chang-Mo,Kim, Mi Hyun,Son, Myung Jin,Song, Hyun Seok,Shin, Hyung-Jin,Lee, Dong-Sup,Eoh, Whan,Nam, Do-Hyun National Hellenic Research Foundation 2006 ONCOLOGY REPORTS Vol.16 No.1
<P>Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Temozolomide (TMZ), a methylating agent is one of the most effective chemotherapeutic agents against glioblastoma. To overcome the problem that most of these tumors become resistant to chemotherapeutic regimens within a year, we investigated the antitumor efficacy of metronomic administration of low-dose TMZ in in vitro cell proliferation/cytotoxicity assay and in vivo rat and nude mouse orthotopic glioma model. By in vitro assay, we elucidated that C6/LacZ rat glioma cells were more resistant to metronomic treatment of TMZ than U-87MG human glioblastoma cells and bEnd.3 mouse brain endothelial cells. Compared with the conventional chemotherapeutic regimen of TMZ, we found that frequent administration of TMZ at a low dose (metronomic treatment) markedly inhibited angiogenesis as well as tumor growth in a TMZ-resistant C6/LacZ rat glioma model. In addition, metronomic treatment of TMZ significantly augmented apoptosis of tumor cells in this model. For the TMZ-sensitive U-87MG cells, even with a very low dose of TMZ, which is not effective to reduce tumor mass, the metronomic treatment of TMZ reduced the microvessel density, i.e. angiogenesis, in a nude mouse orthotopic model. In conclusion, for both models, the metronomic treatment of TMZ decreased angiogenesis. Especially, in TMZ-resistant glioma cells, this regimen increased apoptosis of tumor cells and decreased tumor growth. The metronomic treatment of TMZ in orthotopic glioma models demonstrated a successful antiangiogenic effect which can overcome the chemoresistance in conventional TMZ chemotherapy.</P>
Kim, Min Chul,Jeong, Myung Ho,Sim, Doo Sun,Hong, Young Joon,Kim, Ju Han,Ahn, Youngkeun,Ahn, Tae Hoon,Seung, Ki Bae,Choi, Dong-Joo,Kim, Hyo-Soo,Gwon, Hyeon Cheol,Seong, In Whan,Hwang, Kyung Kuk,Chae, S Elsevier 2018 The American journal of cardiology Vol.121 No.11
<P>The optimal timing of percutaneous coronary intervention (PCI) in patients with non–ST-segment elevation myocardial infarction (NSTEMI), complicated by acute decompensated heart failure (ADHF), is unclear. A total of 1,027 patients with NSTEMI complicated by ADHF who underwent successful PCI were analyzed using a Korean multicenter registry. All patients were divided into 4 groups by the timing of PCI: group 1 (PCI < 2 hour after admission, n = 149), group 2 (2 to 24 hours, n = 577), group 3 (24 to 72 hours, n = 189), and group 4 (≥72 hours, n = 112). We analyzed the incidences of 12-month mortality, nonfatal myocardial infarction (MI), target-vessel revascularization, and rehospitalization because of HF. The prevalence of ADHF in patients with NSTEMI was 15.2% at initial presentation, and in-hospital mortality was higher in group 1 than in the other groups. There were no significant differences in mortality, nonfatal MI, target-vessel revascularization, or rehospitalization for HF during the 12-month follow-up between groups, regardless of initial PCI timing, except for a higher 12-month mortality in patients who received PCI within 24 hours (vs ≥24 hours) (hazard ratio 1.52, 95% confidence interval 1.09 to 2.29, p = 0.046). Early PCI did not reduce adverse clinical outcomes in patients with NSTEMI complicated by ADHF. Delayed PCI after stabilization may be reasonable in such high-risk patients.</P>
비 낭종성 양성 갑상선 결절의 Tetracycline 경화 요법
김종순,김옥,김종호,김윤자,이병두,문병천,김광회,문재환 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.1
Percutaneous tetracycline injection (PTI) is a sclerosing method for the treatment of the pure thyroid cyst. PTI of 23 cases of benign thyroid nodules (solid echopattern-six, mixed echopattern-nine, cystic echopattern-six, resected nodules-two cases) were done with 23-G needle under the guidance of ultrasonography. After then, we followed up ultrasonographical size and volume of nodules, thyroid function test, cytology, histopathological examination and complications of treatment. The results were as follows: 1) with 0.5-2ml tetracycline injection, the mean volume of thyroid nodules were reduced after PTI at 6 months.In the solid nodules, (4.70 1.20 4.44 2.67)(ml)(p$gt;0.05) In the mixed nodules, (13.59 7.85 4.34 6.73)(ml)(p$lt;0.05) In the cystic nodules, (20.33 21.66 6.79 8.32)(ml)(p$lt;0.05) 2) The echogenicity was decreased of unchanged in the most solid and mixed nodules but increased in the cystic nodules. 3) There were no significant changes at 6 months follow-up of TFT after PTI in all cases as compared with the base line studies. 4) Aspiration cytologic finding shows the decreased number of thyroid follicular cells, the increased number of macrophages, a few foam cells and the cytoplasm containing the pale brown foreign body. (Tetracycline phagocytosis).Histopathologic finding shows the destruction and sclerotic changes of the cystic degenerated follicles with infiltration of the lymphocytes and macrophages. 5) The complication such as burning sensation, pain and tenderness developed in the two cases but disappeared within several days. In conclusion, sclerotherapy using tetracycline is a safe and effective adjunctive treatment of the benign mixed of cystic thyroid nodules and Percutaneous Alcohol Injection (PAI) is recommendable for solid nodules. (J Kor Soc Endocrinol 6:58 67, 1991)
Kim Jae Heon,Shim Ji Sung,Kim Jong Wook,Doo Seung Whan,Bae Jae Hyun,Lee Ju Han,Song Yun Seob,Kim Je Jong,Moon Du Geon 대한남성과학회 2020 The World Journal of Men's Health Vol.38 No.3
Purpose: To validate a novel arteriogenic erectile dysfunction (ED) model with atherosclerosis (AS) based on molecular and histologic evidence induced by chronic pelvic ischemia (CPI) and determine effect of phosphodiesterase-5 inhibitor treatment. Materials and Methods: Twenty 16-week-old male Sprague–Dawley rats were divided into three experimental groups (Group I, untreated sham-operated rats with regular diet; Group II, CPI with cholesterol diet; Group III, CPI model with cholesterol diet and mirodenafil). Erectile function was accessed using maximum intracavernous pressure (ICP) and ICP/mean arterial pressure (MAP). Molecular changes were examined by western blot analysis using hypoxia inducible factor 1-alpha (HIF-1α), endothelial nitric oxide synthase (eNOS), and transforming growth factor beta-1 (TGF-β1) antibodies. Collagen change was evaluated by Masson’s trichrome staining. Results: In vivo measurements of ICP and ICP/MAP in Group II were significantly lower than those in Group I (p<0.01). Smooth muscle/collagen ratio in Group II was significantly lower than that in Group I (p<0.05). After treatment with mirodenafil for four weeks, Group III showed significantly higher levels of ICP and ICP/MAP than Group II (p<0.05). Western blot analysis showed that HIF-1α and TGF-β1 levels were significantly higher in Group II whereas eNOS levels were significantly lower in Group II than those in Group I or III. Conclusions: A novel arteriogenic ED with AS model is successfully induced by CPI and validated based on molecular and histologic evidences.
Polysilsesquioxane-b-Polycaprolactone의 합성과 특성
강두환 ( Doo Whan Kang ),김선택 ( Sun Teak Kim ),이병철 ( Byoung Chul Lee ),김영민 ( Young Min Kim ),조원호 ( Won Ho Jo ) 한국공업화학회 2003 공업화학 Vol.14 No.2
Phenyltrichlorosilane과 phenylenediamine을 preamination, 가수분해, 축합반응시켜 융해성이 우수한 ladder형 polyphenylsilsesquioxane (PPSQ)을 제조하였다. PPSQ에 분자량이 조절된 α, ω-hydroxyl polycaprolactone (PCL) prepolymer를 공중합시켜 분자구조가 제어된 polysilsesquioxane-b-polycaprolactone (PPSQ-b-PCL) 공중합체를 제조하였다. PPSQ-b-PCL 공중합체를 ITO glass 위에 코오팅하여 박막을 제조하고 고온에서 PCL segment를 소결시켜 기공의 분산성이 우수한 PPSQ의 박막을 제조하여 그 특성을 측정하였다. 이들의 구조 및 열적 특성은 FT-IR, NMR 및 TGA로 확인하였으며 이들 박막의 모폴로지 및 기공의 분산성은 SEM과 AFM으로 측정하였다. 또한 전기적 특성은 MIM (Metal. Insulator/Metal)방식으로 유전율을 측정하였다. Polyphenylsilsesquioxane-b-polycaprolactone (PPSQ-b-PCL) copolymer, to apply as an interlayer dielectric material, was synthesized from condensation polymerization of α, ω-hydroxyl polycaprolactone (PCL) prepolymer and polyphenylsilsesquioxan (PPSQ). PPSQ was prepared from condensation polymerization of phenyltrichlorosilane and phenylenediamine. PPSQ-b-PCL copolymer was spin-coated on ITO glass and cured in an electric fumace that was equipped with N_2 injection port. By curing of the coated material, sphere-shaped pores was obtained by sintering the PCL segment. The structures of PPSQ-b-PCL, were confirmed by FT-IR and NMR. Their thermal properties were measured by TGA. Morphology, topography, and dielectric constant, according to the contents of PCL in film, were measured by SEM, AFM, and impedance analyzer.