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기장도,박치영,류보열,김태종,모성환,곽재정,문철호,박근홍,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1
Chronic neutrophilic leukemia is a very rare myeloproliferative disorder which is characterized by severe sustained mature neutrophilic leukocytosis in peripheral blood (PB), hepatosplenomegaly, elevated leukocyte alkaline phosphatase, serum uric acid. serun viatmin B 12 and the bleeding tendency despite normal platelet count and coagulation time, absence of philadelphia chromosome, and the absence of fever or underlying infection or disease sufficient to mimic a leukemoid reaction. We have experienced a 34-years-old male patient with atypical chronic neutrophilic leukemia. On admission, the leukocyte count was 56,860/uL. severe neutrophic leukocytosis with 76% neutrophils and rare immature forms on PB smear. Many neutrophils had toxic granules, and vacuoloes. Leukocyte alkaline phosphatase score was decreased. The cytogenetic study showed Philadelphia chromosome negative with normal karyotype.
Chi, Ki-Whan,Hwang, Ho Yun,Jin, Sung Ho,Jeong, Han Mo,Yoon, Koo Sik,Kim, Jong-Man,Lee, Chan Woo Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.13
<P>Electrophoretic fluorescence images have been fabricated by deposition of nanoporous polyaniline–fluorescein conducting particles onto a micro-patterned polyaniline film.</P> <P>Graphic Abstract</P><P>Electrophoretic fluorescence images have been fabricated by deposition of nanoporous polyaniline–fluorescein conducting particles onto a micro-patterned polyaniline film. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b818773h'> </P>
Chi, Ki-Whan,Ahn, Yoon-Soo,Shim, Kwang-Taeg,Huh, Hwang,Ahn, Jeong-Soo Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.5
The aminomethylation of phenols with para-substituents by the Mannich reaction has successfully been accomplished to produce the Mannich bases 2-6. The compounds 7-8 have also been synthesized in order to identify the effect of the side arms and t he macrocycle in the complex formation. Protonation constants and stability constants of the double armed diaza-18-crown-6 ethers 2-7 with metal ions have been determined by potentiometric method at 25 $^{\circ}C$ in 95 % methanol solution. Under a basic condition (pH > 8.0), the double-armed crown ethers 2-6 revealed stronger interaction with divalent metal ions than the simple diazacrown ether 1. The stability constants with these metal ions were Co 2+ < Ni2+ < Cu2+ > Zn 2+ in increasing order, which are in accordance with the order of the Williams-Irving series. The stability constants with alkali earth metal ions were Ca 2+ < Sr 2+ < Ba 2+ in increasing order, which may be explained by the concept of size effect. It is noteworthy that the hosts 2-6, which have phenolic side arms and a macrocycle, bind stronger with metal ions than the hosts 1 and 7. On the other hand, the host 8, which has phenolic side arms with a pyperazine ring,provided comparable stability constants to those with the host 3. These facts demonstrate that phenolic side arms play a more important role than the azacrown ether ring in the process of making a complex with metal ions especially in a basic condition. In particular, the log KML values for complexation of divalent metal ions with the hosts 2-6 had the sequence, i.e., 2 (R=OCH3) < 3 (R=CH3) < 4 (R=H) < 5 (R=Cl) < 6 (R=CF3). The stability constants of the hosts 5 and 6 containing an electron-withdrawing group are larger than those of the hosts 2 and 3 containing an electron-donating group. This substituent effect is attributed to the solvent effect in which the aryl oxide with an electron-donating group has a tendency to be tied strongly with protic solvents.
Chi, Ki-Whan,Shim, Kwang-Taeg,Huh, Hwang,Lee, Uk,Park, Young-Ja Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.3
The stability constants for the diaza-18-crown-6 ethers 2-6 and alkali metal cations ($Na^+,\;K^+,\;Rb^+\;and\;Cs^+$) were determined using potentiometry in 95% methanol. For each metal ion the stability constants of the partiallyfluorinated ligands 3-6 were larger than that of the non-fluorinated ligand 2, which might reflect an interaction between fluorine atoms and alkali metal cations. The stability constant of the ligand 4 was larger than that of the ligand 5 for each metal cation tested. This finding was also supported by the results of cation-induced chemical shifts in $^1H-,\;^{19}F$-NMR and extraction experiment. The potentiometry and NMR results as well as the X-ray crystal structures revealed that the position and number of fluorine atoms in the benzyl side arms was crucial for the enhanced interaction between a ligand and an alkali metal.
Ki-Whan Chi*,Kwang Taeg Shim,Hwang Huh,Uk Lee,박영자 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.3
The stability constants for the diaza-18-crown-6 ethers 2-6 and alkali metal cations (Na+, K+, Rb+ and Cs+) were determined using potentiometry in 95% methanol. For each metal ion the stability constants of the partially-fluorinated ligands 3-6 were larger than that of the non-fluorinated ligand 2, which might reflect an interaction between fluorine atoms and alkali metal cations. The stability constant of the ligand 4 was larger than that of the ligand 5 for each metal cation tested. This finding was also supported by the results of cation-induced chemical shifts in 1H-, 19F-NMR and extraction experiment. The potentiometry and NMR results as well as the X-ray crystal structures revealed that the position and number of fluorine atoms in the benzyl side arms was crucial for the enhanced interaction between a ligand and an alkali metal.
Total Synthesis of Dihydroreynosin and Dihydrosantamarine via Tandem Cope-Claisen Rearrangement
Ki-Whan Chi,Stanley Raucher Korean Chemical Society 1991 Bulletin of the Korean Chemical Society Vol.12 No.2
The total synthesis of dihydroreynosin (1) and dihydrosantamarine (2) via tandem Cope-Claisen rearrangement has been accomplished starting from (S)-carvone (4).