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- 저자 : Kezban Ulubayram (검색결과 2 건)
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Electrospun Nanofibers for Dual and Local Delivery of Neuroprotective Drugs
Mohammad Karim Haidar,Selin Seda Timur,Gülen Melike Demirbolat,Emirhan Nemutlu,R. Neslihan Gürsoy,Kezban Ulubayram,Levent Öner,Hakan Eroğlu 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2
Drug delivery for neuroprotection/neuroregeneration after traumatic peripheral nerve injuries still remains achallenge. For this purpose, we formulated composite nanofiber formulation for the dual local delivery of alpha lipoic acid(ALA) and atorvastatin (ATR) to enhance regeneration process after peripheral nerve injury. The initial stage involvedencapsulation of ATR into nanosprayed chitosan (CH) nanoparticles after which the CH nanoparticles were embedded intopoly(lactic-co-glycolic acid) (PLGA) nanofibers containing freely dispersed ALA within the fiber structure. Morphologyinvestigations revealed that smooth and randomly aligned nanofibers with mean diameter of 340±69 nm were formed. Encapsulation efficiency for ALA and ATR were calculated as 92.76±3.53 % and 89.27±5.053 %, respectively. DifferentialScanning Calorimetry and FT-IR analysis confirmed successful encapsulation of ALA and ATR into the compositenanofibers; however, XRD results indicated surface localization of ALA within the structure. Porosity and pore volume of thenanofibers increased in accordance with increase in density of the electrospunned solution. Similarly, mechanical strength ofthe nanofibers was found to increase significantly following the incorporation of ALA and ATR with respect to the unloadednanofibers (p<0.05). Dual release of ALA and ATR in different fashions was confirmed by in-vitro release test of thenanofibers. For ALA, an immediate release percentage of 83.90 % within the first hour was observed. On the other hand,ATR exhibited a three-stage release profile which begins with a relatively lower initial release (22.07 %) in comparison toALA followed by an increasing release (82.439 %) up to 150 h. According to cell viability results, blank and loadedformulations were found to have no cytotoxic effect on both L-929 and B35 cell lines after incubation for up to 48 h. Basedon this, composite PLGA nanofibers could be classified as suitable candidates for long-term and local delivery ofneuroprotective drugs in peripheral nerve injury.
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Eda Ayse Aksoy,Betul Suyumbike Yagci,Gulseher Manap,Ipek Eroglu,Sukru Ozturk,Melike Ekizoglu,Kezban Ulubayram 한국섬유공학회 2019 Fibers and polymers Vol.20 No.11
In this study, it was aimed to develop drug eluting biodegradable and biocompatible bone supportive fibers andfilms, which can locally be applicable on the infected bone defect area for osteomyelitis treatment. For this purpose,vancomycin (Vm) loaded gelatin (G) microspheres were prepared and dispersed into poly(ε-caprolactone) (PCL) solutionand then the suspension was processed as films and fibers by solvent casting and wet spinning techniques, respectively. Themean particle size distribution and morphology of Vm loaded G microspheres were characterized by laser diffraction methodand scanning electron microscopy, respectively. In vitro Vm release profiles and release kinetics from microsphere, fiber andfilm formulations were investigated. In vitro biodegradation properties of fiber and film formulations were examined in bothhydrolytic and enzymatic media during 25 days period. The cytotoxicity of Vm eluting films and fibers were tested on L929cells by MTT assay. Presence of PCL in film and fiber formulations retarded the release of Vm from microspheres andprovided long term sustained release. Vm eluting films and fibers exhibited strong antibacterial properties againstStaphylococcus aureus and Staphylococcus epidermidis.
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