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KeunAh Cheon,DongHwan Lee,JinYong Jun,Kee Namkoong 대한신경정신의학회 2006 PSYCHIATRY INVESTIGATION Vol.3 No.1
Objective: The aim of this study was to evaluate the relationship between such psychosocial variables as the emotional and characteristic factors, and the motivation for weight loss in children with obesity. Methods: Thirty-seven children (mean age: 9.4±1.2 years) between the ages of 7 and 12 who had entered a summer camp for childhood obesity and their parents participated in this study. A questionnaire on the eating habits and life style of the child, the Child Behavioral Checklist (CBCL), and the Child Character Inventory (CCI) were completed by the parents of the subjects. The obese children completed the Child Depression Inventory (CDI) and the Parental Bonding Instrument (PBI) by themselves. We evaluated the motivation of the obese children to lose weight by having them take the Weight Loss Readiness Test (WLRT). Then, we analyzed the correlation between the psychological variables and the WLRT items. Results: The emotional instability scale on the CBCL was correlated with the WLRT item of emotional eating (r=0.336, p=0.042). The harm avoidance scale of the CCI was negatively correlated with the WLRT item on exercise patterns and attitudes (r=-0.047, p=0.014). However, no significant correlation was found between each of the severity scores of the CDI depressive symptoms and the other psychological variables and each of the six WLRT items. Conclusion: Our findings suggest that emotional instability and harm avoidance, as measured by the CCI, are related to the motivation for weight loss in obese children.
WooYoung Im,JiHye Ha,EunJoo Kim,KeunAh Cheon,Jaeil Cho,DongHo Song 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.3
Objective-It is known that many of the cognitive and social deficits associated with autism can arise from abnormal functional connectivity between brain networks. This aberrant functional connectivity in autism spectrum disorders (ASD) can be explained by impaired integrity of white matter tracts that link distant regions of the networks. Methods-We investigated white matter in 9 children with high-function autism (HFA) compared to 13 typically developing controls using diffusion tensor imaging (DTI). The aim of this research is to provide supporting evidence for abnormalities in neural connectivity as an underlying pathophysiology of the main characteristics of ASD. Results-We found impairment of neural connectivity, mainly in association fiber tracts as evidenced by decreased fractional anisotropy (FA), the index of white matter integrity, of these tracts. Among them, inferior fronto-occipital fasciculus (IFOF) had a significant relationship with ADI-R score. The inferior longitudinal fasciculus (ILF) and superior longitudinal fasciculus (SLF) also showed decreased FA. Decreased FA of ILF and SLF had negative correlations with scores of social interaction. Conclusion-These findings suggest that widespread abnormalities in association fiber tracts may contribute to both core and associated symptoms of ASD.
DongHo Song,Soul Choi,YooSook Joung,EunHye Ha,BoongNyun Kim,YeeJin Shin,Dongwon Shin,HeeJeong Yoo,KeunAh Cheon 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.3
Objective-This study was aimed to determine effectiveness and tolerability of Osmotic-controlled Release Oral delivery (OROS) methylphenidate (MPH) and its optimal dose administered openly over a period of up to 12 weeks in drug naïve Korean children with ADHD. Methods-Subjects (n=143), ages 6 to 18-years, with a clinical diagnosis of any subtype of ADHD were recruited from 7 medical centers in Korea. An individualized dose of OROS-MPH was determined for each subject depending on the response criteria. The subjects were assessed with several symptom rating scales in week 1, 3, 6, 9 and 12. Results-77 of 116 subjects (66.4%) achieved the criteria for response and the average of optimal daily dose for response was to 30.05±12.52 mg per day (0.90±0.31 mg/kg/d) at the end of the study. Optimal dose was not significantly different between ADHD subtypes, whereas, significant higher dose was needed in older aged groups than younger groups. The average of optimal daily dose for response for the subjects aged above 12 years old was 46.38±15.52 per day (0.81±0.28 mg/kg/d) compared to younger groups (p<0.01). No serious adverse effects were reported and the dose did not have a significant effect on adverse effects. Conclusion-Optimal mean dose of OROS-MPH was significantly different by age groups. Higher dose was needed in older aged groups than younger groups. Effectiveness and tolerability of OROS-MPH in symptoms of ADHD is sustained for up to 12 weeks.