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Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.
SOLUTION OF THE SUPER BESSEL WAVE EQUATION WITH INTEGRAL PARAMETER m
Lee, Nae-Ja,Liu, Chang-Keng Korean Mathematical Society 1983 대한수학회보 Vol.20 No.2
Internal heat generation is one of the insidious conditions affecting the quality of an industrial product after it is cast, coated, molded, forged or laminated. Frequently, the product is pressed into service before the exothermic chemical reactions in the generic material has been completed. The heat liberated from this continuing chemical reaction or the residual deformation from the rheological activities in the materials must be adequately removed or prevented, or the product may be discolored, warped, weakened or even "ignited" spontaneously. Numerous instances of premature structural failures, product-recalls, and/or system-malfunctions have been recorded in recent history. The Coulee Dam was poured with pre-chilled concrete just to negate this freakish encore. It is well-known that concrete (a non-isotropic conducting medium), for instance, takes 28 days to develop its full strength. During this period of curing it is conceivable that the processes of internal heat generation, heat conduction and heat dissipation take place simultaneously inside the medium.he medium.
Yao-Chun Yang,Min-Hong Hsieh,Jui-Teng Chien,Keng-Chang Liu,Chang-Chen Yang 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.1
Objectives: Sacral insufficiency fracture (SIF) is not an uncommon osteoporosis fracture among the elderly. Aside from traditional treatments, sacroplasty and teriparatide (TPTD) injection have been introduced. This report aims to compare the effects of sacroplasty and teriparatide on clinical outcomes of SIF. Methods: Thirty-one elderly patients with SIF were enrolled in this retrospective observational study. Four male patients were excluded. Fourteen patients who received TPTD for 6 months were classified into the TPTD group (TT), and 13 who underwent sacroplasty were classified into the sacroplasty group (SS). All patients in both groups were instructed to take calcium and vitamin D supplements daily. Their symptoms and signs, visual analog score (VAS), Oswestry disability index (ODI), and radiographic studies were retrospectively reviewed. Results: The TT group showed significantly lower VAS than SS group after 3 (P < 0.001) and 6 months of treatment (P < 0.001). The TT group also has significant lower ODI than SS group after 1 (P = 0.010), 3 (P = 0.005) and 6 months (P < 0.001) of treatment. Upon generalized estimating equations (GEE) analysis, the TT group showed significantly more reduction in both VAS and ODI compared to the SS group at 1 month (P = 0.022, P = 0.001), 3 months (P < 0.001, P < 0.001), and 6 months (P < 0.001, P < 0.001) post-treatment. Conclusions: Postmenoposal woman with SIF who received TPTD healed better than those who underwent sacroplasty after 1 month treatment.