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Martin Hennessy,Keith Kelso Hussey 대한혈관외과학회 2023 Vascular Specialist International Vol.39 No.1
Purpose: We aimed to describe our technique for and experience with elective endovascular aneurysm repair using EndoAnchors under local anesthesia. Materials and Methods: We included seven patients with abdominal aortic aneurysms who underwent endovascular aneurysm repair using EndoAnchors with a standard regimen consisting of local anesthesia, intravenous sedation, and analgesia. The procedural and follow-up details were retrospectively reviewed. Results: Six out of seven infrarenal abdominal aortic aneurysms were successfully treated with endovascular aneurysm repair using primary EndoAnchors under local anesthesia. One patient was converted to general anesthesia due to acute aneurysm thrombosis independent of EndoAnchor deployment during the procedure. Remifentanyl infusions of up to 3.2 mg/min, morphine doses up to 6 mg (median, 0.5 mg), and midazolam doses of up to 4 mg (mean, 1.4 mg) were used. The mean theater time was 83 minutes (range, 60–130 minutes). Two patients were discharged on day 0, and the mean hospital stay was one day. All patients were alive between 484 and 1,128 days post-procedure, with no aneurysm-specific reintervention. Conclusion: The combination of local anesthesia, intravenous sedation, and analgesia is a viable strategy for timely and effective endovascular aneurysm repair using EndoAnchors. This technique may allow endovascular repair of more ruptured aneurysms using EndoAnchors with potential survival benefits.
GAIT: Gene expression Analysis for Interval Time
Kim, Yoojoong,Kang, Yeong Seon,Seok, Junhee,Kelso, Janet Oxford University Press 2018 Bioinformatics Vol.34 No.13
<P>Supplementary information: Supplementary data are available at Bioinformatics online.</P>
Motamedinia Behnam,Skevington Jeffrey H.,Kelso Scott 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
The Middle Eastern big-headed fly genus Clistoabdominalis Skevington, 2001 (Diptera: Pipunculidae) is revised including five new species: C. arabicus Motamedinia & Skevington sp. nov., C. nanus Motamedinia & Skevington sp. nov., C. persicus Motamedinia & Skevington sp. nov., C. platyphalligus Motamedinia & Skevington sp. nov. and C. tribulosus Motamedinia & Skevington sp. nov. Eudorylas ascitus De Meyer, 1995 is transferred to Clistoabdominalis, C. ascitus comb. nov. Descriptions of new species, diagnoses, COI DNA barcodes for some species, distribution maps and an illustrated key for all species are provided.
조철현,이헌정,우현구,최지혜,Tiffany A. Greenwood,John R. Kelsoe 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.3
Although bipolar disorder is highly heritable, the identification of specific genetic variations is limited because of the complex traits underlying the disorder. We performed a genome-wide association study of bipolar disorder using a subphenotype that shows hypersomnia symptom during a major depressive episode. We investigated a total of 2,191 cases, 1,434 controls, and 703,012 single nucleotide polymorphisms (SNPs) in the merged samples obtained from the Translational Genomics Institute and the Genetic Association Information Network. The gene emerging as the most significant by statistical analysis was rs1553441 (odds ratio=0.4093; p=1.20×10-5; Permuted p=6.0×10-6). However, the 5×10-8 threshold for statistical significance required in a genome-wide association study was not achieved. The functional enrichment pathway analysis showed significant enrichments in the adhesion, development-related, synaptic transmission- related, and cell recognition-related pathways. For further evaluation, each gene of the enriched pathways was reviewed and matched with genes that were suggested to be associated with psychiatric disorders by previous genetic studies. We found that the cadherin 13 and hypocretin (orexin) receptor 2 genes may be involved in the hypersomnia symptom during a major depressive episode of bipolar disorder.
Synergistic Phytochemicals Fail to Protect Against Ovariectomy Induced Bone Loss in Rats
Suresh Ambati,Colette N. Miller,Erica F. Bass,Natalie M. Hohos,Diane L. Hartzell,Emily W. Kelso,Emily R. Trunnell,양정예,Mary Anne Della-Fera,Clifton A. Baile,Srujana Rayalam 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.10
Menopause induces a loss of bone as a result of estrogen deficiency. Despite pharmaceutical options for the treatment of osteopenia and osteoporosis, many aging women use dietary supplements with estrogenic activity to prevent bone loss and other menopausal-related symptoms. Such supplements are yet to be tested for efficacy against a Food and Drug Administration (FDA) approved medication for menopausal bone loss such as zoledronic acid (ZA). The postmenopausal rat model was used to investigate the efficacy of various synergistic phytochemical blends mixed into the diet for 16 weeks. Retired-breeder, Fischer 344 rats were randomly assigned to sham or ovariectomy surgery and 4 treatment groups: ZA; genistein supplementation; and a low dose and high dose blend of genistein, resveratrol, and quercetin. Ovariectomy resulted in a loss of both trabecular and cortical bone which was prevented with ZA. The phytochemical blends tested were unable to reverse these losses. Despite the lack of effectiveness in preventing bone loss, a significant dose–response trend was observed in the phytochemical-rich diets in bone adipocyte number compared to ovariectomized control rats. Data from this study indicate that estrogenic phytochemicals are not as efficacious as ZA in preventing menopausal-related bone loss but may have beneficial effects on bone marrow adiposity in rats.