제4형 가족성 고중성지방혈증 임산부에서 발생한 급성 췌장염 1례

박관응,윤채중,김영학,진영기,윤성호,권용은,김태원,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

Plasma levels of cholesterol (TC) and triglyceride(TG) physiologically increase during pregnancy. The lipid increment is 23-53% above the pregravidic level for TC and 2- to 3-fold of the prepregnancy level for TG. If the TC and TG are higher than normal values in pregnancy, the patient must be carefully monitored. Acute pancreatitis is the main consequence of hyperlipidemia and occurs either during pregnancy, in the third trimester, or in the puerperium. Mortality is high both for the mother (21%) and the fetus (20%). We report a case of 28 year-old pregnant woman at 29 weeks gestation with hypercholesterolemia (TC = 357 ㎎/dl) and severe hypertriglyceridemia (TG = 1300 ㎎/dl). The patient was admitted to the hospital because of severe epigastric pain, nausea and vomiting. Total serum cholesterol was increased and trigyleride was markedly increased. The electroporesis pattern of serum lipoprotein showed increase in pre-beta lipoprotein fraction, suggesting IV hypertriglyceridemia pattern. According to a review of the literature, the incidence of pancreatitis during pregnancy is 1 in 1000 to 3000 pregnancies. Severe hypertriglyceridemia in pregnancy should be treated with a careful restriction of calories and fat: for preventing acute pancreatitis, hospitalization for intravenous fluid therapy and plasma exchange must be required.

LiNbO₃기판을 사용한 광 도파로의 설계 및 분석

강기성,채기병,소대화,박정철 明知大學校 産業技術硏究所 1991 産業技術硏究所論文集 Vol.10 No.-

In this paper, we calculate refractive index change of optical waveguide and electric field to simulate y-cut LiNbO₃optical waveguide at He-Ne laser (λ=0.6328[㎛]) by BPM mechanism. At waveguide width of 4[㎛], buffer layer of 0.02[㎛] of LiNbO₃ substrate (XI 55[㎛] x ZI 5000[㎛], we observed electric field Ex, Ey in x, y-direction. By applying these parameters of single waveguide to simulate a X-switch, we have chosen index change of 0.002, width of 3[㎛] and angle of 0.4。∼0.6°of optical waveguide and under these conditions, optical beam propagates cross-side at 0.4° When applied switching vlotage of 25[V], optical beam of X-switch turns cross-side to bar-side at intersection angle 0.4° index change of 0.002, wavegulde width of 3[㎛], electrode gap 2[㎛]. By the above results, we can obtain the basis design conditions of X-switch optical modulator. And optical single waveguide is fabricated on the y-cut LiNbO₃ single crystal substrate by Ti-indiffusion method. The line-width of the waveguide was made from 4[㎛] to 6[㎛]that observed single mode at 4[㎛] as a result of propagation of He-Ne(0.6328[㎛]) laser beam.

ION-SELECTIVE ELECTRODES OF FERRITE MEMBRANES

원충택,박면용,오평제,이원,박기채 상명대학교 논문집 1993 상명대학교논문집 Vol.31 No.-

산화제2철 또는 산화제2철과 마그네슘, 구리, 니켈, 혹은 아연을 몰비가 0.6:2.4, 0.8:2.2, 1:2, 1.2:1.8 및 1.4:1.6 (M:Fe, M=Mg, Cu, Ni, Zn) 인 혼합물로 Ferrite막 전극을 만들어 이온 선택성 전극으로 사용될 가능성을 연구하였다. 이들 전극막 재료는 각각 900, 1,000, 1,100, 1,200, 1,300, 및 2,614-2,700℃에서 소결되었다. 소결 온도가 높을수록 이온 감도와 선택성이 컸다. 산화제2철만을 사용하였을 때 보다 산화제2철을 Mg,Cu,Ni 또는 Zn과 혼합하여 2,164-2,700℃ 에서 소결된 전극들이 이온 선택성이 우수하였다. 이들 전극의 전기저항치는 10^2 메그옴정도이다. 모든 전극의 정전앞감응을 pH3 및 10사이에서 관찰하였는데, 은(I), 인산염(III), 인산일수소염(II), 인산이수소염(I) 및 비소(V, III)에 민감하게 감응되었다. 이들전극은 물속에 계속해서 담궈두면 내구도가 6개월 정도였다.

자궁의 동정맥기형에 의한 제왕절개술 후 질출혈

전영은 ( Young Eun Jeon ),윤명근 ( Myoung Kun Yoon ),김성주 ( Sung Joo Kim ),장봉림 ( Pong Rheem Jang ),강정배 ( Jung Bae Kang ),박영한 ( Young Han Park1 ),임채춘 ( Chae Chun Rhim ),민수기 ( Soo Kee Min ) 대한주산의학회 2006 Perinatology Vol.17 No.1

Uterine arteriovenous malformations are very rare but potentially life threatening lesions. These lesions may be congenital or acquired, but especially occur in patients with a history of curettage, abortion or pregnancy. Color doppler ultrasonography is the preferred method of diagnosing of arteriovenous malformations. In many cases, hysterectomies are performed. But if patients want pregnancies, embolization therapy and conservative treatment are effective therapy. We have experienced a clinical case of uterine arteriovenous malformation, which is presented with a brief review of literature.

O⁶-alkylguanine-DNA alkyltransferase gene polymorphisms and the risk of primary lung cancer

Chae, Myung Hwa,Jang, Jin-Sung,Kang, Hyo-Gyoung,Park, Jae Hyung,Park, Jung Min,Lee, Won Kee,Kam, Sin,Lee, Eung Bae,Son, Ji-Woong,Park, Jae Yong Wiley Subscription Services, Inc., A Wiley Company 2006 Molecular Carcinogenesis Vol.45 No.4

<P>O<SUP>6</SUP>-alkylguanine-DNA alkyltransferase (AGT) plays an important role in the repair of O<SUP>6</SUP>-alkylguanine adducts, which are major mutagenic lesions produced by environmental carcinogens. Polymorphisms in the AGT gene may affect the capacity to repair DNA damage and thereby have influence on individual's susceptibility to smoking-related cancer. To test this hypothesis, we investigated the potential association of AGT polymorphisms (485C > A, Leu53Leu (C > T) and Leu84Phe] with the risk of lung cancer in a Korean population. The AGT genotypes were determined in 432 lung cancer patients and in 432 healthy controls who were frequency-matched for age and gender. The 485 AA genotype was associated with a significantly increased risk for overall lung cancer as compared with the 485 CC genotype and the combined 485 CC + CA genotype, respectively (adjusted odds ratio (OR) = 1.83, 95% confidence interval (CI) = 1.12–2.99, P = 0.02, and Bonferroni corrected P-value (Pc) = 0.04; and adjusted OR = 1.67, 95% CI = 1.05–2.66, P = 0.03, respectively). When the lung cancer cases were categorized by the tumor histology, the 485 AA genotype was associated with a significantly increased risk of adenocarcinoma (AC) and small cell carcinoma (SmCC), respectively, as compared with the combined 485 CC + CA genotype (adjusted OR = 2.54, 95% CI = 1.39–4.66, P = 0.003; and adjusted OR = 2.19, 95% CI = 1.06–4.55, P = 0.04, respectively). However, the genotype distributions of the Leu53Leu and Leu84Phe polymorphisms were not significantly different between the lung cancer cases and the controls. On a promoter assay, the 485C > A polymorphism did not have an effect on the promoter activity of the AGT gene. These results suggest that the effect of the AGT 485C > A polymorphism on the risk of lung cancer may be secondary to linkage disequilibrium (LD) with either another AGT variant or with a true susceptibility gene, and that the AGT 485C > A polymorphism could be used as a marker for the genetic susceptibility to lung cancer. © 2005 Wiley-Liss, Inc.</P>

Molecular analysis of <i>myocilin</i> and <i>optineurin</i> genes in Korean primary glaucoma patients

Park, Joonhong,Kim, Myungshin,Park, Chan Kee,Chae, Hyojin,Lee, Seungok,Kim, Yonggoo,Jang, Woori,Chi, Hyun Young,Park, Hae-Young Lopilly,Park, Shin Hae D.A. Spandidos 2016 MOLECULAR MEDICINE REPORTS Vol.14 No.3

<P>To investigate the underlying genetic influences of primary glaucoma in Korea, molecular analysis was performed in 112 sporadic cases, and results compared with healthy controls. The <I>myocilin</I> (<I>MYOC</I>) and <I>optineurin</I> (<I>OPTN</I>) genes were directly sequenced in 112 unrelated patients, including 17 with primary open-angle glaucoma, 19 with juvenile open-angle glaucoma, and 76 with normal tension glaucoma. Healthy unrelated Korean individuals (n=100) were used as the non-selected population control. A total of three <I>MYOC</I> and four <I>OPTN</I> variants potentially associated with primary glaucoma were identified in 4 and 18 patients, respectively. A novel variant of <I>MYOC</I>, <I>p.Leu255Pro</I>, was predicted to be potentially pathogenic by <I>in silico</I> analysis. Another, <I>p.Thr353Ile</I>, has been previously reported. These two missense variants were detected in patients with a family history of glaucoma. Combined heterozygous variants <I>p.[Thr123=;Ile288=]</I> were identified in 2 of 112 (2%) patients but not in healthy controls. Among <I>OPTN</I> variants, a novel variant <I>p.Arg271Cys</I> was identified. Homozygous <I>p.[Thr34=;Thr34=]</I> (4/112, 4%), homozygous <I>p.[Met98Lys;Met98Lys]</I> (4/112, 4%), or combined heterozygous <I>p.[Thr34=;Arg545Gln]</I> (9/112, 8%) was significantly associated with the development of primary glaucoma [odds ratio (OR)=8.768, 95% confidence interval (CI)=1.972–38.988; relative risk=1.818, 95% CI=1.473–2.244; P=0.001]. The present study provides insight into the genetic or haplotype variants of <I>MYOC</I> and <I>OPTN</I> genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea. Further studies, including those on additional genes, are required to elucidate the underlying pathogenic mechanism using a larger cohort to provide additional statistical power.</P>

Methylation status of the MGMT gene promoter fails to predict the clinical outcome of glioblastoma patients treated with ACNU plus cisplatin

Park, Chul-Kee,Park, Sung-Hye,Lee, Se-Hoon,Kim, Chae-Yong,Kim, Dong-Wan,Paek, Sun Ha,Kim, Dong Gyu,Heo, Dae Seog,Kim, Il Han,Jung, Hee-Won Blackwell Publishing Asia 2009 NEUROPATHOLOGY Vol.29 No.4

<P>We analyzed the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter using a methylation-specific polymerase chain reaction (MSP) in glioblastoma patients treated with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) plus cisplatin followed by radiation therapy. Forty-eight patients with interpretable MSP results were included in this study. The MGMT promoter was methylated in 26 patients (54.2%, methylated group) and unmethylated in 22 patients (45.8%, unmethylated group). Comparison of clinical outcomes between the two groups revealed that the methylation status of the MGMT gene promoter was not a prognostic factor for overall survival (<I>P</I> = 0.516) or a predictive factor for radiological response to ACNU plus cisplatin treatment (<I>P</I> = 0.529). The most noteworthy explanation for the result is that the synergistic antitumor effects of ACNU and cisplatin resulting from inactivation of MGMT by cisplatin in MGMT active tumors offset the drug resistance.</P>

Interplay between TRAP1 and Sirtuin-3 Modulates Mitochondrial Respiration and Oxidative Stress to Maintain Stemness of Glioma Stem Cells

Park, Hye-Kyung,Hong, Jun-Hee,Oh, Young Taek,Kim, Sung Soo,Yin, Jinlong,Lee, An-Jung,Chae, Young Chan,Kim, Jong Heon,Park, Sung-Hye,Park, Chul-Kee,Park, Myung-Jin,Park, Jong Bae,Kang, Byoung Heon American Association for Cancer Research 2019 Cancer Research Vol.79 No.7

<P>Discovery and functional analysis of a TRAP1-SIRT3 complex in glioma stem cells identify potential target proteins for glioblastoma treatment.</P><P><B></B></P><P>Glioblastoma (GBM) cancer stem cells (CSC) are primarily responsible for metastatic dissemination, resistance to therapy, and relapse of GBM, the most common and aggressive brain tumor. Development and maintenance of CSCs require orchestrated metabolic rewiring and metabolic adaptation to a changing microenvironment. Here, we show that cooperative interplay between the mitochondrial chaperone TRAP1 and the major mitochondria deacetylase sirtuin-3 (SIRT3) in glioma stem cells (GSC) increases mitochondrial respiratory capacity and reduces production of reactive oxygen species. This metabolic regulation endowed GSCs with metabolic plasticity, facilitated adaptation to stress (particularly reduced nutrient supply), and maintained “stemness.” Inactivation of TRAP1 or SIRT3 compromised their interdependent regulatory mechanisms, leading to metabolic alterations, loss of stemness, and suppression of tumor formation by GSC <I>in vivo</I>. Thus, targeting the metabolic mechanisms regulating interplay between TRAP1 and SIRT3 may provide a novel therapeutic option for intractable patients with GBM.</P><P><B>Significance:</B></P><P>Discovery and functional analysis of a TRAP1–SIRT3 complex in glioma stem cells identify potential target proteins for glioblastoma treatment.</P>

자연과학편 : 인공방사성 (人工放射性) 동위원소와 그 이용

박기채 ( Kee Chae Park ) 고려대학교 경영대학 1955 고려대학교50주년 기념논문집 Vol.- No.-

Gypenoside UL4-Rich <i>Gynostemma pentaphyllum</i> Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease

Bae, Ui-Jin,Park, Eun-Ock,Park, John,Jung, Su-Jin,Ham, Hyeonmi,Yu, Kee-Won,Park, Young-Jun,Chae, Soo-Wan,Park, Byung-Hyun World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.6

<P>Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. <I>Gynostemma pentaphyllum</I> extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supplemented with various doses of UL4-rich GPE for eight weeks. GPE supplementation suppressed oxidative stress induced by the MCD diet by increasing levels of sirtuin 6 and phase 2 anti-oxidant enzymes in mouse liver and HepG2 cells. Additionally, GPE supplementation prevented diet-induced hepatic fat accumulation, hepatocellular injury, inflammation, and fibrosis in mice fed the MCD diet. These results indicate the possible therapeutic potential of dietary supplementation of UL4-rich GPE in preventing the development of fatty liver and its progression to NASH.</P>