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Mahmood A. Hamed,Seiichi Nakata,Kazuya Shiogama,Kenji Suzuki,Ramadan H. Sayed,Yoichi Nishimura,Noboru Iwata,Kouhei Sakurai,Badawy S. Badawy,Ken-ichi Inada,Hayato Tsuge,Yutaka Tsutsumi 대한이비인후과학회 2017 Clinical and Experimental Otorhinolaryngology Vol.10 No.3
Objectives. Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate them with its bone destructive capacity. Methods. A prospective quantitative immunohistochemical study was carried out using fresh acquired cholesteatoma tissues (n=19), collected during cholesteatoma surgery. Deep meatal skin tissues from the same patients were used as control (n=8). Cholesteatoma patients were divided into 2 groups and compared (invasive and noninvasive) according to a grading score for bone resorption based upon clinical, radiologic and intraoperative findings. To our knowledge, the role of CK17 in cholesteatoma aggressiveness was first investigated in this paper. Results. Both Ki-67 and CK17 were significantly overexpressed in cholesteatoma than control tissues (P<0.001 for both Ki-67 and CK17). In addition, Ki-67 and CK17 were significantly higher in the invasive group than noninvasive group of cholesteatoma (P=0.029, P=0.033, respectively). Furthermore, Ki-67 and CK17 showed a moderate positive correlation with bone erosion scores (r=0.547, P=0.015 and r=0.588, P=0.008, respectively). In terms of CK13, no significant difference was found between cholesteatoma and skin (P=0.766). Conclusion. Both Ki-67 and CK17 were overexpressed in cholesteatoma tissue and positively correlated with bone resorption activity. The concept that Ki-67 can be a predictor for aggressiveness of cholesteatoma was supported. In addition, this is the first study demonstrating CK17 as a favoring marker in the aggressiveness of acquired cholesteatoma.
Sudhagar, P.,Devadoss, Anitha,Song, Taeseup,Lakshmipathiraj, P.,Han, Hyungkyu,Lysak, Volodymyr V.,Terashima, C.,Nakata, Kazuya,Fujishima, A.,Paik, Ungyu,Kang, Yong Soo The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.33
<P>We demonstrate one-step gold nanoparticle (AuNP) coating and the surface nitridation of TiO<SUB>2</SUB> nanowires (TiO<SUB>2</SUB>-NWs) to amplify visible-light photon reflection. The surface nitridation of TiO<SUB>2</SUB>-NW arrays maximizes the anchoring of AuNPs, and the subsequent reduction of the band gap energy from 3.26 eV to 2.69 eV affords visible-light activity. The finite-difference time-domain (FDTD) simulation method clearly exhibits the enhancement in the strengths of localized electric fields between AuNPs and the nanowires, which significantly improves the photocatalytic (PC) performance. Both nitridation and AuNP decoration of TiO<SUB>2</SUB>-NWs result in beneficial effects of high (e<SUP>−</SUP>/h<SUP>+</SUP>) pair separation through healing of the oxygen vacancies. The combined effect of harvesting visible-light photons and reducing recombination in Au/N-doped TiO<SUB>2</SUB>-NWs promotes the photocatalytic activity towards degradation of methyl orange to an unprecedented level, ∼4 fold (1.1 × 10<SUP>−2</SUP> min) more than does TiO<SUB>2</SUB>-NWs (2.9 × 10<SUP>−3</SUP> min<SUP>−1</SUP>). The proposed AuNP decoration of nitridated TiO<SUB>2</SUB>-NW surfaces can be applied to a wide range of n-type metal oxides for photoanodes in photocatalytic applications.</P> <P>Graphic Abstract</P><P>Maximizing the Au nanoparticle decoration on TiO<SUB>2</SUB> nanowire through nitrogen doping for simultaneous enhancement in visible light scattering and electron–hole charge separation. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cp02009j'> </P>