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- 저자 : Kawser Hossain, Mohammed (검색결과 2 건)
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Kawser Hossain, Mohammed,Abdal Dayem, Ahmed,Han, Jihae,Kumar Saha, Subbroto,Yang, Gwang-Mo,Choi, Hye Yeon,Cho, Ssang-Goo MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.2
<P>Diabetes mellitus (DM) is a widespread metabolic disease with a progressive incidence of morbidity and mortality worldwide. Despite extensive research, treatment options for diabetic patients remains limited. Although significant challenges remain, induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any cell type, including insulin-secreting pancreatic β cells, highlighting its potential as a treatment option for DM. Several iPSC lines have recently been derived from both diabetic and healthy donors. Using different reprogramming techniques, iPSCs were differentiated into insulin-secreting pancreatic βcells. Furthermore, diabetes patient-derived iPSCs (DiPSCs) are increasingly being used as a platform to perform cell-based drug screening in order to develop DiPSC-based cell therapies against DM. Toxicity and teratogenicity assays based on iPSC-derived cells can also provide additional information on safety before advancing drugs to clinical trials. In this review, we summarize recent advances in the development of techniques for differentiation of iPSCs or DiPSCs into insulin-secreting pancreatic β cells, their applications in drug screening, and their role in complementing and replacing animal testing in clinical use. Advances in iPSC technologies will provide new knowledge needed to develop patient-specific iPSC-based diabetic therapies.</P>
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Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus
Mohammed Kawser Hossain,최혜연,황재선,Ahmed Abdal Dayem,김정현,김영봉,부하령,조쌍구 한국미생물학회 2014 The journal of microbiology Vol.52 No.6
Influenza virus infection causes thousands of deaths and millionsof hospitalizations worldwide every year and the emergenceof resistance to anti-influenza drugs has promptedscientists to seek new natural antiviral materials. In this study,we screened 13 different flavonoids from various flavonoidgroups to identify the most potent antiviral flavonoid againsthuman influenza A/PR/8/34 (H1N1). The 3-hydroxyl groupflavonoids, including 3,2'-dihydroxyflavone (3,2'-DHF) and3,4 -dihydroxyflavone (3,4'-DHF), showed potent anti-influenzaactivity. They inhibited viral neuraminidase activityand viral adsorption onto cells. To confirm the anti-influenzaactivity of these flavonoids, we used an in vivo mousemodel. In mice infected with human influenza, oral administrationof 3,4'-DHF significantly decreased virus titers andpathological changes in the lung and reduced body weightloss and death. Our data suggest that 3-hydroxyl group flavonoids,particularly 3,4'-DHF, have potent antiviral activityagainst human influenza A/PR/8/34 (H1N1) in vitro and invivo. Further clinical studies are needed to investigate thetherapeutic and prophylactic potential of the 3-hydroxylgroup flavonoids in treating influenza pandemics.
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