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      저자 : Kavitha Srinivasa (검색결과 3 건)
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        A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans

        Kavitha Srinivasa,최원자,Jihyun Kim,Subog Yee,김완기 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.2

        Hydrogen peroxide (H2O2) functions as a ubiquitous intracellular messenger besides as an oxidative stress molecule. This dual role is based on the distinct cellular responses against different concentrations of H2O2. Previously, we demonstrated that both low (> 1 mM) and high (4-10 mM) doses of exogenous H2O2 induce filamentous growth with distinct cell morphology and growth rate in Candida albicans, suggesting the different transcription response. In this study, we revealed that the sub-toxic and toxic levels of H2O2 indeed induced pseudohyphae, but not true hyphae. Supporting this, several hyphae-specific genes that are expressed in true hyphae induced by serum were not detected in either sub-toxic or toxic H2O2 condition. A DNA microarray analysis was conducted to reveal the transcription profiles in cells treated with sub-toxic and toxic conditions of H2O2. Under the sub-toxic condition, a small number of genes involved in cell proliferation and metabolism were up-regulated, whereas a large number of genes were up-regulated in the toxic condition where the genes required for growth and proliferation were selectively restricted. For pseudohyphal induction by sub-toxic H2O2, Cek1 MAPK activating the transcription factor Cph1 was shown to be important. The absence of expression of several hyphae-specific genes known to be downstream targets of Cph1-signaling pathway for true hyphae formation suggests that the Cek1-mediated signaling pathway is not solely responsible for pseudohyphal formation by sub-toxic H2O2 and, but instead, complex networking pathway may exists by the activation of different regulators.

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        Characterization of a Putative Thioredoxin Peroxidase Prx1 of Candida albicans

        Kavitha Srinivasa,최원자,Na-Rae Kim,Jiwon Kim,Minsun Kim,Ju Yun Bae,정우진,김완기 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.3

        In this study, we characterized a putative peroxidase Prx1 of Candida albicans by: 1) demonstrating the thiore-doxin-linked peroxidase activity with purified proteins, 2) examining the sensitivity to several oxidants and the accumulation of intracellular reactive oxygen species with a null mutant (prx1∆), a mutant (C69S) with a point mutation at Cys69, and a revertant, and 3) subcelluar localization. Enzymatic assays showed that Prx1 is a thioredoxin-linked peroxidase which reduces both hydrogen peroxide (H2O2) and tert-butyl hydroperoxide (t-BOOH). Compared with two other strong H2O2 scavenger mutants for TSA1 and CAT1, prx1∆ and C69S were less sensitive to H2O2, menadione and diamide at all concentrations tested, but were more sensitive to low concentration of t-BOOH. Intracellular reactive oxygen species accumulated in prx1∆ and C69S cells treated with t-BOOH but not H2O2. These results suggest that peroxidase activity of Prx1 is specified to t-BOOH in cells. In both biochemical and physiological cases, the evolutionarily conserved Cys69 was found to be essential for the function. Immunocytochemical staining revealed Prx1 is localized in the cytosol of yeast cells, but is translocated to the nucleus during the hyphal transition, though the significances of this observation are unclear. Our data suggest that PRX1 has a thioredoxin peroxidase activity reducing both t-BOOH and H2O2, but its cellular function is specified to t-BOOH.

      • Hydrogen Peroxide Induces Hyphal Differentiation in Candida albicans

        Nasution, Olviyani,Srinivasa, Kavitha,Kim, Minsun,Kim, Yeo-Jung,Kim, Wankee,Jeong, Woojin,Choi, Wonja American Society for Microbiology 2008 EUKARYOTIC CELL Vol.7 No.11

        <B>ABSTRACT</B><P>In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H2O2 in <I>Candida albicans.</I> This finding is confirmed by the changing intracellular concentration of H2O2. In order to induce the same level of differentiation, low concentrations of exogenous H2O2 are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.</P>

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