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Pamela Ferrari,Mariana Migliorini Parisi,Rafael Colombo,Matheus Becker,Gabriel Fries,Bruna Maria Ascoli,Luiza Paul Géa,Márcia Kauer-Sant’anna,Flávio Kapczinski,Fábio Klamt,Fátima T.C.R. Guma,Adriane R 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.1
Objective: Evidence has suggested that immune imbalance is involved with bipolar disorder (BD); however, its precise mechanism is poorly understood. This study investigated whether biochemical changes in the serum from BD patients could modulate the phenotype of cultured macrophages. Methods: Eighteen subjects with BD and five healthy individuals were included in this study. The human monocyte cell line U-937 was activated with phorbol 12-myristate 13-acetate (PMA) and polarization was induced with RPMI-1640 media supplemented with 10% serum from each patient for 24 hours. Gene expression of selected M1 and M2 markers was assessed by quantitative PCR. Results: Macrophages exposed to serum of manic and depressive BD patients displayed an increase of interleukin-1 (6.40±3.47 and 9.04±5.84 vs. 0.23±0.11; p<0.05) and tumor necrosis factor- (2.23±0.91 and 2.03±0.45 vs. 0.62±0.24; p=0.002 and p=0.004, respectively) compared to euthymic group (there was no difference between euthymic and controls). In parallel, U-937 macrophages treated with serum of patients in acute episode displayed a down-regulation of CXCL9 (0.29±0.20 vs. 1.86±1.61; p=0.006) and CXCL10 expression (0.36±0.15 and 0.86±0.24 vs. 1.83±0.88; p<0.000 and p=0.04) compared to the euthymia group. Conclusion: Our results are consistent with previous studies showing that changes in peripheral blood markers could modulate M1/M2 polarization in BD. The evidence of macrophages as source of inflammatory cytokines might be helpful to unravel how the mononuclear phagocyte system is involved in the etiology of BD.
First Direct Search for Inelastic Boosted Dark Matter with COSINE-100
Ha, C.,Adhikari, G.,Adhikari, P.,Barbosa de Souza, E.,Carlin, N.,Choi, S.,Djamal, M.,Ezeribe, A. C.,Hahn, I. S.,Jeon, E. J.,Jo, J. H.,Joo, H. W.,Kang, W. G.,Kang, W.,Kauer, M.,Kim, G. S.,Kim, H.,Kim, American Physical Society 2019 Physical review letters Vol.122 No.13
Search for a Dark Matter-Induced Annual Modulation Signal in NaI(Tl) with the COSINE-100 Experiment
Adhikari, G.,Adhikari, P.,de Souza, E. Barbosa,Carlin, N.,Choi, S.,Djamal, M.,Ezeribe, A. C.,Ha, C.,Hahn, I. S.,Jeon, E. J.,Jo, J. H.,Joo, H. W.,Kang, W. G.,Kang, W.,Kauer, M.,Kim, G. S.,Kim, H.,Kim, American Physical Society 2019 Physical Review Letters Vol.123 No.3
Background model for the NaI(Tl) crystals in COSINE-100
Adhikari, P.,Adhikari, G.,Souza, E. Barbosa de,Carlin, N.,Choi, S.,Choi, W. Q.,Djamal, M.,Ezeribe, A. C.,Ha, C.,Hahn, I. S.,Hubbard, A. J. F.,Jeon, E. J.,Jo, J. H.,Joo, H. W.,Kang, W. G.,Kauer, M.,Kan Springer Berlin Heidelberg 2018 European Physical Journal C Vol.78 No.6
<P>The COSINE-100 dark matter search experiment is an array of NaI(Tl) crystal detectors located in the Yangyang Underground Laboratory (Y2L). To understand measured backgrounds in the NaI(Tl) crystals we have performed Monte Carlo simulations using the Geant4 toolkit and developed background models for each crystal that consider contributions from both internal and external sources, including cosmogenic nuclides. The background models are based on comparisons of measurement data with Monte Carlo simulations that are guided by a campaign of material assays and are used to evaluate backgrounds and identify their sources. The average background level for the six crystals (70 kg total mass) that are studied is 3.5 counts/day/keV/kg in the (2–6) keV energy interval. The dominant contributors in this energy region are found to be [FORMULA OMISSION]Pb and [FORMULA OMISSION]H.</P>