Neoplastic Transformation Induced by the gep Oncogenes Involves the Scaffold Protein JNK-Interacting Leucine Zipper Protein

Kashef, Kimia,Radhakrishnan, Rangasudhagar,Lee, Clement M.,Reddy, E. Premkumar,Dhanasekaran, Danny N. Elsevier 2011 Neoplasia Vol.13 No.4

<P>The activated mutants of the 관-subunits of G proteins G(12) and G(13) have been designated as the gep oncogenes owing to their ability to stimulate diverse oncogenic signaling pathways that lead to neoplastic transformation of fibroblast cell lines and tumorigenesis in nude mice models. Studies from our laboratory as well as others have shown that the growth-promoting activities of G관(12) and G관(13) involve potent activation of c-Jun N-terminal kinases (JNKs). Our previous studies have indicated that the JNK-interacting leucine zipper protein (JLP), a scaffold protein involved in the structural and functional organization of the JNK/p38 mitogen-activated protein kinase module, tethers G관(12) and G관(13) to the JNK signaling module. In the present study, in addition to demonstrating the physical association between JLP and G관(12), we show that this interaction is enhanced by the receptor- or mutation-mediated activation of G관(12). We also establish that JLP interacts with G관(12) through the C-terminal domain that has been previously identified to be involved in binding to G관(13). Furthermore, using this C-terminal domain as a competitively inhibitor of JLP that can disrupt G관(12)-JLP interaction, we demonstrate that JLP is required for the stimulation of JNK by G관(12). Our results also indicate that such JLP interaction is required for G관(12) as well as G관(13)-mediated neoplastic transformation of JLP. These studies demonstrate for the first time a functional role for JLP in the gep oncogene-regulated neoplastic signaling pathway.</P>

Optimal Packet Scheduling for Energy Harvesting Sources on Time Varying Wireless Channels

Kashef, Mohamed,Ephremides, Anthony The Korea Institute of Information and Commucation 2012 Journal of communications and networks Vol.14 No.2

In this paper, we consider a source node that operates over a time varying channel with energy harvesting capability. The goal of the source is to maximize the average number of successfully delivered packets per time slot. The source is able to choose whether to transmit a packet or defer the transmission in each time slot. The decision which is chosen by the source depends on the channel information available and the length of the energy queue. We formulate the problem of finding the optimal policy as a Markovian decision problem. We show some properties of the value function that represents the discounted number of successfully delivered packets per time slot. We prove that the optimal policy is a threshold type policy depending on the state of the channel and the length of the energy queue. We also derive an upper bound for the average number of packets per time slots successfully received by the destination. We show using numerical results that this bound is a tight bound on the performance of the optimal policy. And we consider the case of time varying channel but without channel state information (CSI). Then, we study the impact of channel time varying nature and the availability of CSI. In this case, we show that the optimal policy is a greedy policy. The performance of this greedy policy is also calculated.

Comparison of Two Yield Management Strategies for Cloud Service Providers

Kashef, M.M.,Uzbekov, A.,Altmann, J.,Hovestadt, M. SPRINGER-VERLAG 2013 ICHIT 2012 Vol.7861 No.-

Optimal Packet Scheduling for Energy Harvesting Sources on Time Varying Wireless Channels

Mohamed Kashef,Anthony Ephremides 한국통신학회 2012 Journal of communications and networks Vol.14 No.2

In this paper, we consider a source node that operates over a time varying channel with energy harvesting capability. The goal of the source is to maximize the average number of successfully delivered packets per time slot. The source is able to choose whether to transmit a packet or defer the transmission in each time slot. The decision which is chosen by the source depends on the channel information available and the length of the energy queue.We formulate the problem of finding the optimal policy as a Markovian decision problem.We show some properties of the value function that represents the discounted number of successfully delivered packets per time slot. We prove that the optimal policy is a threshold type policy depending on the state of the channel and the length of the energy queue.We also derive an upper bound for the average number of packets per time slots successfully received by the destination. We show using numerical results that this bound is a tight bound on the performance of the optimal policy. And we consider the case of time varying channel but without channel state information (CSI). Then, we study the impact of channel time varying nature and the availability of CSI. In this case, we show that the optimal policy is a greedy policy. The performance of this greedy policy is also calculated.

MECHANICAL PROPERITIES OF TITANIUM FOAM FOR BIOMEDICAL APPLICATIONS

SADAF KASHEF,JIANGUO LIN,PETER D. HONHSON,WENYI YAN 한국소성가공학회 2008 한국소성가공학회 컨퍼런스 Vol.2008 No.10

Cost model based service placement in federated hybrid clouds

Altmann, J.,Kashef, M.M. North-Holland 2014 Future generations computer systems Vol.41 No.-

As cloud federation allows companies in need of computational resources to use computational resources hosted by different cloud providers, it reduces the cost of IT infrastructure by lowering capital and operational expenses. This is the result of economies of scale and the possibility for organizations to purchase just as much computing and storage resources as needed whenever needed. However, a clear specification of cost savings requires a detailed specification of the costs incurred. Although there are some efforts to define cost models for clouds, the need for a comprehensive cost model, which covers all cost factors and types of clouds, is undeniable. In this paper, we cover this gap by suggesting a cost model for the most general form of a cloud, namely federated hybrid clouds. This type of cloud is composed of a private cloud and a number of interoperable public clouds. The proposed cost model is applied within a cost minimization algorithm for making service placement decisions in clouds. We demonstrate the workings of our cost model and service placement algorithm within a specific cloud scenario. Our results show that the service placement algorithm with the cost model minimizes the spending for computational services.

The Beneficial and Adverse Effects of Raloxifene in Menopausal Women: A Mini Review

Imaneh Khorsand,Reyhaneh Kashef,Masumeh Ghazanfarpour,Elaheh Mansouri,Sareh Dashti,Talat Khadivzadeh 대한폐경학회 2018 대한폐경학회지 Vol.24 No.3

Objectives: The present mini review aimed to summarize the existing knowledge regarding the beneficial and adverse effects of raloxifene in menopausal women. Methods: This study is a review of relevant publications about the effects of raloxifene on sleep disorder, depression, venous thromboembolism, the plasma concentration of lipoprotein, breast cancer, and cognitive function among menopausal women.Results: Raloxifene showed no significant effect on depression and sleep disorder. Verbal memory improved with administration of 60 mg/day of raloxifene while a mild cognitive impairment risk reduction by 33% was observed with administration of 120 mg/ day of raloxifene. Raloxifene was associated with a 50% decrease in the need for prolapse surgery. The result of a meta-analysis showed a significant decline in the plasma concentration of lipoprotein in the raloxifene group compared to placebo (standardized mean difference, -0.43; 10 trials). A network meta-analysis showed that raloxifene significantly decreased the risk of breast cancer (relative risk, 0.572; 95% confidence interval, 0.327-0.881; P = 0.01). In terms of adverse effects of raloxifene, the odds ratio (OR) was observed to be 1.54 (P = 0.006), indicating 54% increase in the risk of deep vein thrombosis (DVT) while the OR for pulmonary embolism (PE) was 1.05, suggesting a 91% increase in the risk of PE alone (P = 0.03). Conclusions: Raloxifene had no significant effect on depression and sleep disorder but decreased the concentration of lipoprotein. Raloxifene administration was associated with an increased risk of DVT and PE and a decreased risk of breast cancer and pelvic organ prolapse in postmenopausal women.

Overview of the Effect of Herbal Medicines and Isoflavones on the Treatment of Cognitive Functio

( Nasibeh Roozbeh ),( Reyhaneh Kashef ),( Masumeh Ghazanfarpour ),( Leila Kargarfard ),( Leili Darvish ),( Talat Khadivzadeh ),( Fatemeh Rajab Dizavandi ),( Maliheh Afiat ) 대한폐경학회 2018 대한폐경학회지 Vol.24 No.2

Objectives: The current overview aimed to present the effect of herbal medicines on cognitive function among menopausal women. Methods: Two separate authors performed systematic search of the 3 databases of (the MEDLINE Scopus and the Cochrane Central Register Trials) from inception to January 2018. Methodological quality of each study was assessed using the AMSTAR. Results: According to 2 reviews, soy seems to be effective in enhancing summary cognitive function and visual memory. The effect of isoflavones on cognition was affected by treatment duration as six weeks of treatment improved some dimensions of cognitive parameters, including mental flexibility and planning, and longer treatment period (6 months) improved category digit span test, digit symbol test, and visual scanning test score. The effect of phytoestrogen on cognitive function of menopausal women might be altered age, gender, ethnicity, menopausal status, dosage, and length of treatment, types of cognitive test, location, types of soy, and types of phytoestrogen. Combination of Gingko with ginseng could not improve sustained attention, episode memory, category generation or frontal lobe function. Gingko biloba had no significant effect on planning, memory and sustained attention, except for its limited effect on mental flexibility in late menopause. In addition, other herbal medicines like black cohosh showed no effective beneficial. Conclusions: Phytoestrogen, soy and isoflavones might have a limited beneficial effect on some aspects of cognition. The phytoestrogens affecting cognition might be modified by age, gender, ethnicity, menopausal status, dosage, and length of treatment, types of cognitive test, location, types of soy, and types of phytoestrogen. (J Menopausal Med 2018;24:113-118)

Neuronal correlates of cross-modal transfer in the cerebellum and pontine nuclei.

Campolattaro, Matthew M,Kashef, Alireza,Lee, Inah,Freeman, John H The Society 2011 The Journal of neuroscience Vol.31 No.11

<P>Cross-modal transfer occurs when learning established with a stimulus from one sensory modality facilitates subsequent learning with a new stimulus from a different sensory modality. The current study examined neuronal correlates of cross-modal transfer of pavlovian eyeblink conditioning in rats. Neuronal activity was recorded from tetrodes within the anterior interpositus nucleus (IPN) of the cerebellum and basilar pontine nucleus (PN) during different phases of training. After stimulus preexposure and unpaired training sessions with a tone conditioned stimulus (CS), light CS, and periorbital stimulation unconditioned stimulus (US), rats received associative training with one of the CSs and the US (CS1-US). Training then continued on the same day with the other CS to assess cross-modal transfer (CS2-US). The final training session included associative training with both CSs on separate trials to establish stronger cross-modal transfer (CS1/CS2). Neurons in the IPN and PN showed primarily unimodal responses during pretraining sessions. Learning-related facilitation of activity correlated with the conditioned response (CR) developed in the IPN and PN during CS1-US training. Subsequent CS2-US training resulted in acquisition of CRs and learning-related neuronal activity in the IPN but substantially less little learning-related activity in the PN. Additional CS1/CS2 training increased CRs and learning-related activity in the IPN and PN during CS2-US trials. The findings suggest that cross-modal neuronal plasticity in the PN is driven by excitatory feedback from the IPN to the PN. Interacting plasticity mechanisms in the IPN and PN may underlie behavioral cross-modal transfer in eyeblink conditioning.</P>

The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children

Soheila Alyasin,Tooba Momen,Sara Kashef,Abbass Alipour,Reza Amin 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.4

Purpose: Asthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this study, the associations of 25-hydroxy vitamin D3 levels with asthma and with the severity of asthma were evaluated. Methods: This cross-sectional study was conducted on 50 asthmatic children and 50 healthy controls aged 6–18 years. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups. The relationship between serum vitamin D levels and pulmonary function test outcomes and eosinophil counts were examined in asthmatic patients. Results: Univariate analysis of the relationship between asthma and vitamin D showed that decreased vitamin D levels were associated with significantly increased odds of asthmatic state (P=0.002). In a multivariate analysis after adjustment for age, body mass index, and sex, the relationship between vitamin D and asthma increased. In asthmatic patients, 25-hydroxy vitamin D levels had direct and significant correlations with both predicted FEV1 (R2=0.318; P=0.024) and FEV1/FVC (R2=0.315; P=0.026). There were no associations between vitamin D level and eosinophil counts, duration of disease, and the number of hospitalization or unscheduled visits in the previous year (P>0.05). Conclusions: These results showed that serum 25-hydroxy vitamin D levels were inversely associated with asthma, and there was a direct and significant relationship between vitamin D levels and pulmonary function test outcomes in asthmatic children. An interventional study in asthmatic patients with low serum vitamin D concentration may establish a causal relationship between asthma and vitamin D.