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Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells
KIM, KARAM,AN, SUNGKWAN,CHA, HWA JUN,CHOI, YEONG MIN,CHOI, SUNG JIN,AN, IN-SOOK,LEE, HONG GHI,MIN, YOO HONG,LEE, SU-JAE,BAE, SEUNGHEE D.A. Spandidos 2013 Oncology letters Vol.5 No.2
<P>Non-small cell lung cancer (NSCLC) is the most deadly type of cancer worldwide. Although a number of therapies are used in NSCLC treatment, their therapeutic efficacy remains low. Lenalidomide was originally approved for use in patients with myelodysplastic syndromes, which are associated with 5q deletions, and multiple myeloma. Recently, lenalidomide was investigated as a new NSCLC treatment, and it exerted anticancer effects. However, the primary cellular mechanism of its effects in NSCLC is largely unknown. Therefore, we attempted to elucidate a molecular portrait of lenalidomide-mediated cellular events in NSCLC. Lenalidomide reduced the viability of several NSCLC cell lines in a concentration-dependent manner. In addition, array-based gene expression analysis revealed that lenalidomide regulated the expression of several genes associated with cell survival, apoptosis and development, including BH3-interacting domain death agonist (BID), v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) and NK2 homeobox1 (NKX2-1). BID and FOS, which are known apoptosis activators, were upregulated by lenalidomide treatment, whereas NKX2-1, which is used as an immunohistochemistry marker for NSCLC, was downregulated. These results provide evidence that lenalidomide directly induces antiproliferative effects by altering the expression of genes associated with cell proliferation and apoptosis.</P>
저부하 운전 시 절탄기 바이패스 적용에 따른 석탄화력발전소 성능 예측
최병선(Byeongseon Choi),한가람(Karam Han),김정면(Jeong-Myun Kim),최동권(Dongkwon Choi),이욱륜(Wook-Ryun Lee) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
As the amount of renewable energy generation increases, flexible resources are needed to stably operate the power system. Coal-fired power plants also need to improve their flexibility in order to contribute to stabilizing the power system, such as lowering the minimum load, increasing the ramp rate, and reducing the start-up time. However, as the Selective Catalytic Reduction(SCR) inlet gas temperature decreases during low-load operation, the denitrification efficiency decreases and a large amount of nitrogen oxide is discharged into the atmosphere. In this study, the SCR inlet temperature was maintained above 300°C by applying the economizer bypass to maintain high catalyst activity at low-load, and then the performance of the coal-fired power plant was predicted. When the economizer bypass is applied, the amount of heat supplied to the economizer is reduced and water cannot be sufficiently heated, so additional fuel is required, which increases the heat rate.
최동권(Dongkwon Choi),한가람(Karam Han),김정면(JeongMyeon Kim),최병선(ByeongSeon Choi),송승헌(Seungheon Song),우주희(Joohee Woo),이욱륜(Wookryun Lee) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
As power generation methods based on renewable energy are distributed, the development of flexible operation technologies for existing thermal power generation is emerging. During flexible operation, life time reduction due to combustion instability and thermal fatigue is predicted and sufficient research is needed. In this study, the combustion according to the shape information of the boiler nozzle tip is analyzed, and the combustion point is analyzed by the thickness of the nozzle tip into two stage.
Karam Kang,Kwang Yoon Jung,Doh Young Lee,Jae Hyung Kim,Hye Min Han,ln Hak Choi,Seung-Kuk Baek,Hyunjung Kim 대한연하장애학회 2018 대한연하장애학회지 Vol.8 No.1
Objective: Pharyngoesophageal stricture formation and dysphagia following total laryngectomy negatively affect quality of life and result in nutritional compromise that can be successfully managed with various techniques. This study was conducted to describe our experiences of office-based balloon dilatation by transnasal endoscopy, which can be performed by an otolaryngologist. Method: The present study investigated three patients who underwent transnasal endoscopy guided balloon dilatation of pharyngoesophageal stricture. The assessment was performed based on the number of procedures and recurrences, final subjective outcomes, and complications. Result: There were no post-procedural complications. In one patient, a scarric band was found after the procedure; therefore, steroids were injected into the stricture site. There were 2–3 balloon dilatations and the interval between dilatations was 3–6 months. All patients were able to tolerate solid diet after 2 or 3 sessions. Conclusion: Transnasal endoscopic balloon dilatation, which can be easily performed by an otolaryngologist in an office setting without sedation or general anesthesia, can be a useful modality for treating pharyngoesophageal stricture after total laryngectomy. (
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
Kim, Karam,Yang, Jinhee,Zhong, Xiao-Ping,Kim, Myoung-Hwan,Kim, Yun Sook,Lee, Hyun Woo,Han, Seungnam,Choi, Jeonghoon,Han, Kihoon,Seo, Jinsoo,Prescott, Stephen M,Topham, Matthew K,Bae, Yong Chul,Koretzk Published for the European Molecular Biology Organ 2009 The EMBO journal Vol.28 No.8
<P>Diacylglycerol (DAG) is an important lipid signalling molecule that exerts an effect on various effector proteins including protein kinase C. A main mechanism for DAG removal is to convert it to phosphatidic acid (PA) by DAG kinases (DGKs). However, it is not well understood how DGKs are targeted to specific subcellular sites and tightly regulates DAG levels. The neuronal synapse is a prominent site of DAG production. Here, we show that DGKzeta is targeted to excitatory synapses through its direct interaction with the postsynaptic PDZ scaffold PSD-95. Overexpression of DGKzeta in cultured neurons increases the number of dendritic spines, which receive the majority of excitatory synaptic inputs, in a manner requiring its catalytic activity and PSD-95 binding. Conversely, DGKzeta knockdown reduces spine density. Mice deficient in DGKzeta expression show reduced spine density and excitatory synaptic transmission. Time-lapse imaging indicates that DGKzeta is required for spine maintenance but not formation. We propose that PSD-95 targets DGKzeta to synaptic DAG-producing receptors to tightly couple synaptic DAG production to its conversion to PA for the maintenance of spine density.</P>
성대에서 발견된 재발성 T세포 림프종에 대한 증례 보고
강가람(Karam Kang),최인학(In Hak Choi),이도영(Doh Young Lee),백승국(Seung-Kuk Baek),정광윤(Kwang Yoon Jung) 대한두경부종양학회 2017 대한두경부 종양학회지 Vol.33 No.2
Background. Lymphoma of the vocal fold is extremely rare due to low lymphoid content in the larynx. To date, fewer than 100 cases of laryngeal lymphoma have been reported; however, none of these literatures are concerned about exclusive laryngeal involvement of recurred lymphoma which initially appeared in other body sites. Specific consensus about management for these patients yet to exist, due to its rare occurrence; however, the main modality of treatment is chemotherapy alone or in combination with radiation therapy. Case. Herein, we report a case of a 51-year-old female patient who had recurrent T-cell lymphoma developing in bilateral vocal folds. The patient was originally diagnosed of T-cell lymphoma in right colic flexure 10 years ago, and was cured by chemotherapy. Immunohistochemical stain revealed the histologic type of recurred tumor in the vocal folds that are identical to the previously cured lymphoma. Conclusion. To the best of our knowledge, this was the first case that recurrent lymphoma occurred solely in the vocal folds. Despite its rarity, lymphoma should be put in the index of suspicion among those patients with decreased vocal fold mucosal wave without definite vocal fold mass who had a history of cured lymphoma.
Farag, Ahmed Karam,Hassan, Ahmed H.E.,Jeong, Hyeanjeong,Kwon, Youngji,Choi, Jin Gyu,Oh, Myung Sook,Park, Ki Duk,Kim, Yun Kyung,Roh, Eun Joo Elsevier 2019 European journal of medicinal chemistry Vol.162 No.-
<P><B>Abstract</B></P> <P>Kinase irregularity has been correlated with several complex neurodegenerative tauopathies. Development of selective inhibitors of these kinases might afford promising anti-tauopathy therapies. While DAPK1 inhibitors halt the formation of tau aggregates and counteract neuronal death, CSF1R inhibitors could alleviate the tauopathies-associated neuroinflammation. Herein, we report the design, synthesis, biological evaluation, mechanistic study, and molecular docking study of novel CSF1R/DAPK1 dual inhibitors as multifunctional molecules inhibiting the formation of tau aggregates and neuroinflammation. Compound <B>3l</B>, the most potent DAPK1 inhibitor in the <I>in vitro</I> kinase assay (IC<SUB>50</SUB> = 1.25 μM) was the most effective tau aggregates formation inhibitor in the cellular assay (IC<SUB>50</SUB> = 5.0 μM). Also, compound <B>3l</B> elicited potent inhibition of CSF1R in the <I>in vitro</I> kinase assay (IC<SUB>50</SUB> = 0.15 μM) and promising inhibition of nitric oxide production in LPS-induced BV-2 cells (55% inhibition at 10 μM concentration). Kinase profiling and hERG binding assay anticipated the absence of off-target toxicities while the PAMPA-BBB assay predicted potentially high BBB permeability. The mechanistic study and selectivity profile suggest compound <B>3l</B> as a non-ATP-competitive DAPK1 inhibitor and an ATP-competitive CSF1R inhibitor while the <I>in silico</I> calculations illustrated binding of compound <B>3l</B> to the substrate-binding site of DAPK1. Hence, compound <B>3l</B> might act as a protein-protein interaction inhibitor by hindering DAPK1 kinase reaction through preventing the binding of DAPK1 substrates.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Multifunctional DAPK1 and CSF1R inhibitors for targeting tauopathies. </LI> <LI> <B>3l</B> shows good potency and excellent affinity and within-family selectivity for both kinases. </LI> <LI> Mechanistic study showed <B>3l</B> as non-ATP-competitive DAPK1 inhibitor and ATP-competitive CSF1R inhibitor. </LI> <LI> <B>3l</B> has tau aggregation inhibition and anti-neuroinflammatory activity in cellular assays. </LI> <LI> hERG binding and PAMPA assays revealed <B>3l</B> as a cardiosafe and has a high membrane penetration. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
최동욱(Donguk Choi),문가람(Karam Moon),강창존(Changjon Kang),이계호(Kyeho Lee) 한국자동차공학회 2023 한국자동차공학회 학술대회 및 전시회 Vol.2023 No.11
It need to study which Rear Cross Member Body mounting`s structures are applied to many kinds of car, and which one is better at fatigue strength. So, this paper describes a study of Body Mounting`s structure. The study shows that Increasing the trim line of body mounting`s panel until the welding bead line`s angle is over 180 degree is effective way to enhance the fatigue strength.