과학 문제 대면 상황에서 상태호기심 및 상태불안 유발에 영향을 미치는 학습자 변인에 대한 연구

강지훈 ( Kang¸ Jihoon ),김지나 ( Kim¸ Jina ) 한국초등과학교육학회 2021 초등과학교육 Vol.40 No.3

본 연구는 초등학교 5∼6학년을 대상으로 과학 문제 대면 상황에서 학습자 변인이 상태호기심 및 상태불안 유발에 미치는 영향을 밝히는 데 목적이 있다. 상태호기심 및 상태불안 유발에 영향을 줄 것으로 예상되는 학습자 변인으로 과학호기심, 흥미, 인지욕구, 과학자아개념, 과학불안, 사전지식, 학생이 인식한 과제난이도를 선정하였다. 분석 결과, 과학 문제 대면 상황에서 유발되는 상태호기심에 유의한 영향을 미치는 변인은 흥미, 인지욕구, 과학호기심, 사전지식 순으로 나타났으며, 이들 변인은 모두 정적인 영향을 미쳤다. 또한 과학 문제 대면 상황에서 유발되는 상태불안에 유의한 영향을 미치는 변인은 과학불안, 학생이 인식한 과제난이도, 인지욕구, 과학자아개념, 사전지식 순으로 나타났다. 이중 사전지식만 상태불안 유발에 부적인 영향을 미쳤고 나머지 변인들은 정적인 영향을 미쳤다. 본 연구의 결과는 과학 학습에서 학생의 정서적 상태에 대한 이해의 폭을 넓히고, 과학 학습에서 유발되는 상태호기심 및 상태불안 연구에 대한 이론적 토대를 마련할 것으로 기대된다. The purpose of this study was to clarify the effect of learner variables on triggering state curiosity and state anxiety in confronting scientific task situation for fifth to sixth grades of elementary school. Science curiosity, interest, need for cognition, science self-concept, science anxiety, prior knowledge, and perceived difficulty were selected as learner variables that are expected to affect state curiosity and state anxiety. As a result of this study, the variables that had a significant influence on evoking state curiosity in confronting scientific task situation were in the order of interest, need for cognition, science curiosity, and prior knowledge, and all of these variables had a positive effect. In addition, the variables that significantly affect on evoking state anxiety in confronting scientific task situation were in the order of science anxiety, perceived difficulty, need for cognition, science self-concept, and prior knowledge. Of these, only prior knowledge had a negative effect on evoking state anxiety, and the other variables had a positive effect. The results of this study are expected to broaden the comprehension of students’ emotional states in science education, and provide a theoretical foundation for the studies of state curiosity and state anxiety in science learning.

Stochastic Response Analysis for Multivariate Manufacturing Processes

Jihoon Kang(강지훈),Daehun Youn(윤대훈),Keun Hyung Kim(김근형),Seoung Bum Kim(김성범),Seung Hwan Park(박승환) 한국신뢰성학회 2020 한국신뢰성학회 학술대회논문집 Vol.2020 No.7

Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells

Kang, Shinhae,Song, Jihoon,Kang, Heekyoung,Kim, Sejae,Lee, Youngki,Park, Deokbae 濟州大學校 基礎科學硏究所 2001 基礎科學硏究 Vol.16 No.1

Objective : Insulin has well-known activities in controlling energy metabolism, cellular proliferation and biosynthesis of functional molecules to maintain a biological homeostasis. Recently, several studies have suggested that insulin may protect cells from apoptosis in different cell lines: however, little is known about the nature of its anti-apoptotic actigity. In many clinical disorders, including type 2 diabetes mellitus, oxidative stress and the production of reactive oxygen species (ROS) is increased. With these facts as a background, we examined here whether insulin protects HepG2 cells from apoptosis by decreasing oxidative stress and, if so, which signaling steps are involved in this process. Methos : Intracellular DNA content, the degree of nuclear condensation or poly(ADP-ribose) polymerase hydrolysis was measured to verify the occurrence of apoptotic events. Caspase-3 activity and ROS accumulation within cells were also measured. Western blot analysis was performed to identify fignaling molecules activated in response to insulin. Results : Serum starvation resulted in a marked accumulation of ROS, activation of caspase-3, and subsequent apoptotic cell death which were, in turn, markedly blocked by the addition of insulin. The anti-apoptotic activity of insulin was sensitive to blockade of two different signaling steps, activations of phosphatidylinosltol 3-kinase (PI3 kinase) and extracellular signal-regulated protein kinase (ERK). Conclusion : Insulin exerts and anti-apoptotic activity by suppressing the excessive accumulation of ROS within cells though signaling pathways including stimulation of PI3 kinase and ERK in HepG2 cells.

A Depth-Encoding PET Detector Inserting Glass Plate Between Crystal Layers

Jihoon Kang,Yong Choi,Kyu Bom Kim,Jin Ho Jung,Wei Hu,Yong Hyun Chung IEEE 2014 IEEE transactions on nuclear science Vol.61 No.3

<P>This study introduces a depth-encoding PET detector inserting a glass plate between the pixilated scintillation crystal layers. The principle of the proposed design was that the relative amount of light received by each photosensor will be altered by using the glass plate. This change in the light distribution can generate a pattern diagram of the 2D flood histogram that identifies depth position as well as X-Y position of γ-ray interaction. A Monte Carlo simulation was conducted for the assessment of the DOI-PET detector of 4 ×4 array photosensor coupled with 2-layers of LSO arrays which consist of 4 ×4 arrays of 3 ×3 ×10 mm<SUP>3</SUP> discrete crystals. The traced light distribution for each event was converted by the modified resistive charge division networks into the 2D flood histogram. Optical glass plates with 11 different thicknesses that range from 0 to 10 mm with a 1 mm step were modeled. This was done, to estimate the thickness which allows the extraction of the depth information from the 2D flood histogram. An experimental study was performed to acquire the flood histograms of the DOI-PET detectors with 3 and 5 mm thick glass plate. The effect of glass plate on light loss and count rate loss were assessed for two detector configurations with and without glass plate. The simulation results showed that the flood histogram without overlapping of each crystal position can be generated for the detectors by inserting the glass plates with thickness of 3 ~ 10 mm. They were also demonstrated in the acquired representative flood histograms which were obtained by the experimental study. The light and count rate losses measured from DOI-PET detector with 3 mm thick glass plate was ~ 5% and ~ 2%, respectively. This study demonstrated that the proposed DOI-PET detector can extract the 3D γ-ray interaction position without considerable performance degradations of PET detector from the 2D flood histogram.</P>

Design of Human FIH-1 Inhibitors through Virtual Screening

Jihoon Kang,박광수,정유훈,최정우 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.5

When Does Auto-Parts Suppliers’ Innovation Reduce Their Dependence on the Automobile Assembler?

Jihoon Kang,Soonkyoo Choe 한국무역학회 2020 Journal of Korea trade Vol.24 No.3

Purpose - This study is to investigate the determinants of suppliers’ dependence on buyers in the home country by developing a theoretical model of innovative activities. The high dependence of auto parts suppliers on a single local buyer in South Korea due to firm ownership issues and incremental innovation is examined using data from a set of organizations that supply intermediate goods to this automotive manufacturer. Furthermore, we tested the moderating effect of FDI and global knowledge sourcing on the relationship between firm ownership and suppliers’ dependence on the local buyer. Design/methodology - To test the hypotheses, we examined a sample of 101 suppliers over 10 years in the Korean automobile parts industry. In this empirical analysis, we utilized a fixed-effects generalized least squares model using panel data. Findings - In this study, domestic firms (automobile parts suppliers) were more dependent on a single local buyer (automobile assembler) than foreign-owned suppliers operating in Korea. In addition, incremental innovation was the mediating mechanism between domestic firms and dependence on the local buyer. To reduce this dependence on the buyer, we suggest two different international strategies: geographical diversification through FDI and global knowledge sourcing. Originality/value - Previous studies showed that asymmetric dependence between firms has many adverse effects. This study proved that domestic and foreign-owned suppliers have different levels of dependence on local buyers due to their heterogeneous characteristics and business strategies. We distinguish two different types of innovation - radical innovation and incremental innovation - that previous studies have often treated as equal when it comes to firm autonomy. Finally, we propose that both FDI and international knowledge sourcing as global strategies to weaken suppliers’ asymmetric dependence on a single buyer.

A Study on Electronic Culture Atlas for Mediterranean Region Research

Jihoon Kang,Sangho Moon 한국정보통신학회 2012 2016 INTERNATIONAL CONFERENCE Vol.5 No.1

Routing to Endovascular Treatment of Ischemic Stroke in Korea: Recognition of Need for Process Improvement

Jihoon Kang,김성은,박홍균,조용진,김준엽,이건주,박종무,박광열,이경복,이수주,Ji-Sung Lee,이준영,Ki Hwa Yang,Ah Rum Choi,Mi Yeon Kang,최낙천,Philip B. Gorelick,배희준 대한의학회 2020 Journal of Korean medical science Vol.35 No.41

Background: To track triage, routing, and treatment status regarding access to endovascular treatment (EVT) after acute ischemic stroke (AIS) at a national level. Methods: From national stroke audit data, potential candidates for EVT arriving within 6 hours with National Institute of Health Stroke Scale score of ≥ 7 were identified. Acute care hospitals were classified as thrombectomy-capable hospitals (TCHs, ≥ 15 EVT cases/year) or primary stroke hospital (PSH, < 15 cases/year), and patients' initial routes and subsequent inter-hospital transfer were described. Impact of initial routing to TCHs vs. PSHs on EVT and clinical outcomes were analyzed using multilevel generalized mixed effect models. Results: Out of 14,902 AIS patients, 2,180 (14.6%) were EVT candidates. Eighty-one percent of EVT candidates were transported by ambulance, but only one-third were taken initially to TCHs. Initial routing to TCHs was associated with greater chances of receiving EVT compared to initial routing to PSHs (33.3% vs 12.1%, P < 0.001; adjusted odds ratio [aOR], 2.21; 95% confidence interval [CI], 1.59–2.92) and favorable outcome (38.5% vs. 28.2%, P < 0.001; aOR, 1.52; 95% CI, 1.16–2.00). Inter-hospital transfers to TCHs occurred in 17.4% of those initially routed to a PSH and was associated with the greater chance of EVT compared to remaining at PSHs (34.8% vs. 7.5%, P < 0.001), but not with better outcomes. Conclusion: Two-thirds of EVT candidates were initially routed to PSHs despite greater chance of receiving EVT and having favorable outcomes if routed to a TCH in Korea. Process improvement is needed to direct appropriate patients to TCHs.

Rhamnetin and Cirsiliol Induce Radiosensitization and Inhibition of Epithelial-Mesenchymal Transition (EMT) by miR-34a-mediated Suppression of Notch-1 Expression in Non-small Cell Lung Cancer Cell Lines

Kang, JiHoon,Kim, EunGi,Kim, Wanyeon,Seong, Ki Moon,Youn, HyeSook,Kim, Jung Woo,Kim, Joon,Youn, BuHyun American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.38

<P>Radioresistance is a major cause of decreasing the efficiency of radiotherapy for non-small cell lung cancer (NSCLC). To understand the radioresistance mechanisms in NSCLC, we focused on the radiation-induced Notch-1 signaling pathway involved in critical cell fate decisions by modulating cell proliferation. In this study, we investigated the use of Notch-1-regulating flavonoid compounds as novel therapeutic drugs to regulate radiosensitivity in NSCLC cells, NCI-H1299 and NCI-H460, with different levels of radioresistance. Rhamnetin and cirsiliol were selected as candidate Notch-1-regulating radiosensitizers based on the results of assay screening for activity and pharmacological properties. Treatment with rhamnetin or cirsiliol reduced the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. Indeed, rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA, miR-34a, in a p53-dependent manner, leading to inhibition of Notch-1 expression. Consequently, reduced Notch-1 expression promoted apoptosis through significant down-regulation of the nuclear factor-κB pathway, resulting in a radiosensitizing effect on NSCLC cells. Irradiation-induced epithelial-mesenchymal transition was also notably attenuated in the presence of rhamnetin and cirsiliol. Moreover, an <I>in vivo</I> xenograft mouse model confirmed the radiosensitizing and epithelial-mesenchymal transition inhibition effects of rhamnetin and cirsiliol we observed <I>in vitro</I>. In these mice, tumor volume was significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone. Taken together, our findings provided evidence that rhamnetin and cirsiliol can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.</P>

A feasibility study of photosensor charge signal transmission to preamplifier using long cable for development of hybrid PET-MRI.

Kang, Jihoon,Choi, Yong,Hong, Key Jo,Jung, Jin Ho,Hu, Wei,Huh, Yoon Suk,Lim, Hyunkeong,Kim, Byung-Tae The American Association of Physicists in Medicine 2010 Medical physics Vol.37 No.11

<P>A new positron emission tomography (PET) detector signal processing method, the charge signal transmission approach, is proposed for the development of a hybrid PET-magnetic resonance imaging (MRI). A number of experiments were performed to demonstrate that the Geiger-mode avalanche photodiode (GAPD) charge output could be transmitted to a preamplifier using a long cable without degrading the PET signal performance.</P>