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Ramesh, T.,Yoo, S.K.,Kim, S.W.,Hwang, S.Y.,Sohn, S.H.,Kim, I.W.,Kim, S.K. Pergamon Press ; Elsevier Science Ltd 2012 Experimental Gerontology Vol.47 No.12
Free radical-induced oxidative damage is considered to be the most important consequence of the aging process. The activities and capacities of antioxidant systems of cells decline with increased age, leading to the gradual loss of pro-oxidant/antioxidant balance and resulting in increased oxidative stress. Our investigation was focused on the effects of cordycepin (3'-deoxyadenosine) on lipid peroxidation and antioxidation in aged rats. Age-associated decline in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH), vitamin C and vitamin E, and elevated levels of malondialdehyde (MDA) were observed in the liver, kidneys, heart and lungs of aged rats, when compared to young rats. Furthermore, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine were found to be significantly elevated in aged rats compared to young rats. Aged rats receiving cordycepin treatment show increased activity of SOD, CAT, GPx, GR and GST, and elevated levels of GSH, and vitamins C and E such that the values of most of these parameters did not differ significantly from those found in young rats. In addition, the levels of MDA, AST, ALT, urea and creatinine became reduced upon administration of cordycepin to aged rats. These results suggest that cordycepin is effective for restoring antioxidant status and decreasing lipid peroxidation in aged rats.
Ramesh, T.,Kim, S.W.,Sung, J.H.,Hwang, S.Y.,Sohn, S.H.,Yoo, S.K.,Kim, S.K. Pergamon Press ; Elsevier Science Ltd 2012 Experimental Gerontology Vol.47 No.1
The intracellular levels of oxidant and antioxidant balances are gradually distorted during the aging process. An age associated elevation of oxidative stress occurring throughout the lifetime is hypothesized to be the major cause of aging. The present study was undertaken to evaluate the putative antioxidant activity of the fermented Panax ginseng extract (GINST) on lipid peroxidation and antioxidant status of major organs of aged rats compared to young rats. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea and creatinine were observed in the serum of aged rats. Increased levels of malondialdehyde (MDA) and significantly lowered activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were observed in the liver, kidneys, heart and lungs of aged rats, when compared with those in young rats. Quantitative analysis of the non-enzymatic antioxidants such as reduced glutathione (GSH), ascorbic acid and α-tocopherol levels showed significantly lower values in the liver, kidneys, heart and lungs of aged rats. On the other hand, administration of the fermented Panax ginseng extract (GINST) to aged rats resulted in increased activities of SOD, CAT, GPx, GR and GST as well as elevation in GSH, ascorbic acid and α-tocopherol levels. Besides, the level of MDA, AST, ALT, urea and creatinine were reduced on administration of GINST to aged rats. These results suggested that treatment of GINST can improve the antioxidant status during aging, thereby minimizing the oxidative stress and occurrence of age-related disorders associated with free radicals.
T. Thuamthansanga,B. K. Sahoo,Ramesh Chandra Tiwari 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.1
The study investigates radon and thoron concentrations in soil and water at one of the most prominent faults in Mizoram state, India. The obtained isotope pair data were consequently used for estimating the uranium and thorium content of the region. An indigenously developed and calibrated ZnS(Ag) alpha based scintillation counter (Model: SMARTRnDuo, BARC, India) was deployed for assessing radon and thoron data. Thoron concentration was found to be higher than radon concentration in both soil and water. The isotope pair and their parent nuclei concentration in water were found to be higher than in soil. The uranium and thorium content in soil were estimated to be 17.5 and 22.6 Bqkg<SUP>-1</SUP> respectively, but in water, they were estimated to be 41.6 and 124.8 Bqkg<SUP>-1</SUP> respectively. Comparisons with global averages were also presented in detail and no radiological risk has been observed for the region. A continuous radon data was generated at Mizoram University, Aizawl, Mizoram (India) for cross-analysis with data at Mat fault. It was observed that radon data of the two locations behave similarly during geophysical phenomena, indicating that the region was seismically active. No geophysical properties of thoron were observed.
Estimation of 238U and 232Th in soil and water of prominent fault region of Mizoram
T. Thuamthansanga,B. K. Sahoo,Ramesh Chandra Tiwari 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.1
The study investigates radon and thoron concentrations in soil and water at one of the most prominent faults in Mizoram state, India. The obtained isotope pair data were consequently used for estimating the uranium and thorium content of the region. An indigenously developed and calibrated ZnS(Ag) alpha based scintillation counter (Model: SMARTRnDuo, BARC, India) was deployed for assessing radon and thoron data. Thoron concentration was found to be higher than radon concentration in both soil and water. The isotope pair and their parent nuclei concentration in water were found to be higher than in soil. The uranium and thorium content in soil were estimated to be 17.5 and 22.6 Bqkg−1 respectively, but in water, they were estimated to be 41.6 and 124.8 Bqkg−1 respectively. Comparisons with global averages were also presented in detail and no radiological risk has been observed for the region. A continuous radon data was generated at Mizoram University, Aizawl, Mizoram (India) for cross-analysis with data at Mat fault. It was observed that radon data of the two locations behave similarly during geophysical phenomena, indicating that the region was seismically active. No geophysical properties of thoron were observed.
B. Adil,K. M. Shankar,B. T. Naveen Kumar,Rajreddy Patil,Abhiman Ballyaya,K. S. Ramesh,Sathish Rama Poojary,Omkar V. Byadgi,Prabhugouda Siriyappagouder 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.4
A monoclonal antibody-based flow-through immunoassay (FTA) was developed using a nitrocellulose membrane placed on the top of adsorbent pads enclosed in a plastic cassette with a test zone at the center. The FTA could be completed within 10 min. Clear purple dots against a white background indicated the presence of Aphanomyces (A.)invadans. The FTA limit of detection was 7 μg/mL for A. invadans compared to 56 μg/mL for the immunodot. FTA and polymerase chain reaction (PCR) could detect A. invadans in fish tissue homogenates at a 10-11 dilution compared to a 10-8 dilution by immunodot. In fish suffering from natural cases of epizootic ulcerative syndrome (EUS)collected from Mangalore, India, FTA and PCR could detect A. invadans in 100% of the samples compared to 89.04%detected by immunodot. FTA reagents were stable and produced expected results for 4 months when stored at 4∼8oC. This rapid test could serve as simple and cost-effective on-site screening tool to detect A. invadans in fish from EUS outbreak areas and in ports during the shipment of live or frozen fish.
Yonghyun Kim,V. Ramesh Babu,Daniel T. Thangadurai,K.S.V. krishna Rao,Hyeongrae Cha,김창대,주우홍,이용일 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.2
Copolymeric silver nanocomposite hydrogels were synthesized by using acryloyl phenylalanine (APA), N'-isopropylacrylamide (NIPAM) and crosslinked by N,N-methylene bisacrylamide (MBA) via radical redox polymerization. Present study allows entrapping silver nanoparticles into hydrogel networks. UV-visible spectroscopy and X-ray diffraction (XRD) studies confirmed the formation of silver nanoparticles in hydrogel matrix. 11% of weight loss difference between hydrogel and silver nanocomposite hydrogel is clearly indicates the formation and silver nanoparticles by thermo-gravimetrical analysis. The order of swelling capacity values of hydrogels and silver nanocmposite hydrogels were found to be in the order of placebo copolymeric hydrogel >Ag-copolymeric silver nanocomposite hydrogels. The particle size of silver nanoparticles was analysed and are in the range of 5 - 10 nm which has been confirmed by transmission electron microscopy (TEM) as well as particle size analysis. The silver anocomposite hydrogel has shown very good antibacterial activity on gram-positive and gram-negative bacteriocides.
H. SHINOHARA,P. RAMESH,K. SATO,Y. OZEKI,N. KISHI,T. SUGAI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2006 NANO Vol.1 No.1
Experimental conditions that govern the double-wall carbon nanotube (DWNT) growth during alcohol catalytic chemical vapor deposition (CCVD) have been optimized for mesoporous silica (MCM41) support materials. Catalyst pretreatment and preparation methods influence the quality of as-grown carbon nanotubes (CNTs). Catalyst pretreatment at low pressure leads to high-quality CNTs concomitant with an increase in the DWNT yield. Impregnation of metal precursors using methanol as the solvent is found to be more suitable than the aqueous solution. Influence of the precursor anion/metal ion on the DWNT yield is also studied under these optimized conditions. Thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and Raman spectroscopic methods have been employed to estimate the quality of the CNTs. It is observed that the present optimized method yields high-quality DWNTs with low amounts of side-wall defects and other carbon impurities.
Stimuli-Sensitive Poly(NIPA-co-APA) Hydrogels for the Controlled Release of Keterolac Tromethamine
Kim, Yonghyun,Babu, V. Ramesh,Rao, K.S.V. Krishna,Lim, Jae-Min,Thangadurai, T. Daniel,Lee, Yong-Ill Korean Chemical Society 2014 대한화학회지 Vol.58 No.1
The pH sensitive hydrogels composed of N-isopropylacrylamide (NIPA) and acryloyl phenylalanine (APA) were prepared by redox polymerization using N,N'-methylenebisacrylamide (MBA) as a crosslinker. Anti-inflammatory and analgesic agent, Keterolac Tromethamine (KT), was loaded successfully into poly(NIPA-co-APA) copolymeric hydrogels by swelling equilibrium method. To understand the nature of drug in the polymeric matrix, the newly synthesized drug loaded poly(NIPA-co-APA) copolymeric hydrogels were characterized by using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques. The scanning electron microscopy (SEM) technique result indicates the spherical smooth surface of the hydrogels. The drug (KT) releasing nature of the poly(NIPA-co-APA) hydrogels was studied in pH 1.2 and 7.4. Effects of drug loading, crosslinking agent, pH and the ionic strength of the external medium on swelling of hydrogels were also investigated.