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Open versus closed treatment for extracapsular fracture of the mandibular condyle
Junyeong Lee(Junyeong Lee),Hee-Yeoung Jung(Hee-Yeoung Jung),Jaeyoung Ryu(Jaeyoung Ryu),Seunggon Jung(Seunggon Jung),Min-Suk Kook(Min-Suk Kook),Hong-Ju Park(Hong-Ju Park),Hee-Kyun Oh(Hee-Kyun Oh) 대한구강악안면외과학회 2022 대한구강악안면외과학회지 Vol.48 No.5
Objectives: Selection of treatment methods for mandibular condylar fractures remains controversial. In this study, we investigated treatment methods for condylar fractures to determine the indications for open or closed reduction. Patients and Methods: Patients >12 years of age treated for mandibular condylar fractures with a follow-up period of ≥3 months were included in this study. The medical records of enrolled patients were reviewed for sex, age, fracture site, treatment method (open or closed reconstruction), postop-erative intermaxillary fixation period, operation time, and complications. Radiological analysis of fracture fragment displacement and changes in ramal height difference was performed using computed tomography and panoramic radiography. Results: A total of 198 patients was investigated, 48.0% (n=95) of whom underwent closed reduction and 52.0% (n=103) underwent open reduction. There was no significant correlation between reduction method and patient sex, age, or follow-up period. No statistically significant difference between the incidence of complications and treatment method was observed. None of the patients underwent open reduction of condylar head fracture. Binary logistic regression analysis showed that open reduction was significantly more frequent in patients with subcondylar fracture compared to in those with a fracture in the condylar head area. There was no statistically significant correlation between the groups and fracture fragment displacement. However, there was a significant difference between the treatment groups in amount of change in ramal height difference between the fractured and the non-fractured sides during treatment. Conclusion: No significant clinical differences were found between the open and closed reduction methods in patients with mandibular condylar fractures. According to fracture site, closed reduction was preferred for condyle head fractures. There was no significant relationship between fracture fragment displacement and treatment method.
High-throughput Screening and Selection of Artificial Lactam Riboswitch
Junyeong SUNG,Sungyeon JANG,Sungho JANG,Dae-Kyun IM,Teak jun KANG,Min-Kyu OH,Gyoo Yeol JUNG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Caprolactam is a monomer used for the synthesis of nylon-6. An intracellular biosensor for caprolactam can facilitate high-throughput metabolic engineering of recombinant microbial strains. Because of the mixed production of caprolactam and valerolactam in the recombinant strain, a caprolactam biosensor should be highly specific for caprolactam. However, a highly specific caprolactam sensor has not been reported. Here, we developed an artificial riboswitch that specifically responds to caprolactam. This riboswitch was prepared using a coupled in vitro-in vivo selection strategy with a heterogeneous pool of RNA aptamers obtained from in vitro selection to construct a riboswitch library used in in vivo selection. The caprolactam riboswitch successfully discriminated caprolactam from valerolactam. This riboswitch enabled caprolactam-dependent control of cell growth, which will be useful for improving caprolactam production and is a valuable tool for metabolic engineering.
Junyeong Kim,Kug-Hwan Kim,Dongil Kwon 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.2
Since materials used in or exposed to high-temperature environments can undergo variation or degradation of mechanical properties, it is important to evaluate mechanical properties at high temperature, in particular for structural applications and aerospace materials. Instrumented indentation testing (IIT) is widely used to evaluate such mechanical properties of materials as tensile properties, residual stress, fracture toughness, etc., exploiting theoretical approaches to indentation mechanics. In this study, we used IIT to evaluate variations in tensile properties with temperature of the Ti alloy Ti-6Al-4V, a candidate material for aerospace applications, using a high-temperature chamber and a modified representation method. Comparison of our results with conventional uniaxial tensile test results showed good agreement (within a 10% error range) in yield strength and ultimate tensile strength. This confirms the potential of IIT for evaluating to evaluate high-temperature tensile properties of metallic materials and for research on material behavior in various temperature conditions.