http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : June Bryan dela Pen˜a (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Ike Dela PENA,June Bryan dela Pen˜a,김붕년,한덕현,노민수,정재훈 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Attention-deficit/hyperactivity disorder (ADHD),the most commonly diagnosed neurobehavioral disorder ofchildhood, is usually treated with psychostimulants (e.g.,amphetamine). Little is known about the neuronal and behavioralconsequences of chronic amphetamine use or abuse inindividuals with ADHD. Of all ADHD animal models, thespontaneously hypertensive rat (SHR) is the most validated andwidely used. Here, we analyzed striatal transcriptomes inamphetamine-pretreated SHRs (5 mg/kg, i.p. for 7 days [twicedaily]), which showed a conditioned place preference to andself-administration of amphetamine. Microarray analysesrevealed increased mRNA expression of 55 genes ([1.65-foldincrease), while 17 genes were downregulated (\0.6-fold) inthe striatum of SHRs. The main functional categories overrepresentedamong the differentially expressed genes in thestriatum include those involved in transcription (e.g., Cebpb,Per2), genes associated with angiogenesis (e.g., Kdr, Klf5), celladhesion (e.g., Col11a1, Ctgf), apoptosis (e.g., Nfkbia, Perp)and neuronal development (e.g., Egr2, Nr4a3). In conclusion,we dissected the striatal transcriptional responses to the reinforcingeffects of repeated amphetamine treatment in the SHRmodel ofADHD. Future studies should determine the influenceof these altered transcripts on amphetamine reinforcement inamphetamine-treated SHRs, and the clinical relevance of thepresent findings with regard to amphetamine use/abuse inADHD individuals.
-
Supplementation of Laurus nobilis Attenuate Ethanol-induced Psychomotor Alterations in Rats
Irene Joy I. dela Peña,June Bryan dela Pen˜a,윤서영,김희진,이진희,백세희,서용기,백석준,문병석,정재훈 한국생약학회 2014 Natural Product Sciences Vol.20 No.1
Laurus nobilis (L. nobilis) is traditionally used as an herbal medicine to treat various diseases. Ethanol (EtOH) consumption entails physiological, mental and psychomotor alterations. The aim of the present study was to assess the effects of L. nobilis in attenuating the EtOH-induced psychomotor alterations. L. nobilis was administered to SD rats, 30 minutes before EtOH administration (4 g/kg), at doses of 25, 50 and 100 mg/kg. Evaluations of psychomotor activity in the open-field, accelerating rota-rod, wire, and swimming ability were done at 1, 2, 4 and 8 hours after EtOH administration. In addition, blood ethanol and acetaldehyde levels were also measured. Pre-treatment of L. nobilis significantly improved EtOH-induced psychomotor alterations and decreased blood ethanol and acetaldehyde levels. These findings suggest that L. nobilis might be an effective substance to attenuate the harmful effects of EtOH, particularly psychomotor alterations, and can potentially be considered as a functional food.
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
