http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
FOCAL REDUCER FOR CQUEAN (Camera for QUasars in EArly uNiverse)
Lim, Juhee,Chang, Seunghyuk,Pak, Soojong,Kim, Youngju,Park, Won-Kee,Im, Myungshin The Korean Astronomical Society 2013 Journal of The Korean Astronomical Society Vol.46 No.4
A focal reducer is developed for CQUEAN (Camera for QUasars in EArly uNiverse), which is a CCD imaging system on the 2.1 m Otto Struve telescope at the McDonald observatory. It allows CQUEAN to secure a wider field of view by reducing the effective focal length by a factor of three. The optical point spread function without seeing effects is designed to be within one pixel ($0.283^{\prime\prime}$) over the field of view of $4.82^{\prime}{\times}4.82^{\prime}$ in optimum wavelength ranges of 0.8-1.1 ${\mu}m$. In this paper, we describe and discuss the characteristics of optical design, the lens and barrel fabrications and the alignment processes. The observation results show that the image quality of the focal reducer confirms the expectations from the design.
Lim, Juhee,Kim, Hyo-In,Bang, Yeojin,Seol, Wongi,Choi, Hueng-Sik,Choi, Hyun Jin Wolters Kluwer Health | Lippincott Williams Wilkin 2015 NEUROREPORT - Vol.26 No.6
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor relevant to the development of many mammalian organs including the brain. However, the molecular mechanisms by which signaling events mediate neuronal differentiation have not been fully elucidated. In the present study, we show for the first time that the orphan nuclear receptor estrogen-related receptor &ggr; (ERR&ggr;) is upregulated by HIF-1α and plays essential roles in HIF-1α-induced upregulation of dopaminergic marker molecules such as tyrosine hydroxylase and dopamine transporter. We found that deferoxamine upregulated HIF-1α and enhanced the dopaminergic phenotype and neurite outgrowth of SH-SY5Y cells. Deferoxamine activated transcription and protein expression of ERR&ggr;, and deferoxamine-induced upregulation of tyrosine hydroxylase and dopamine transporter was attenuated by using the ERR&ggr; inverse agonist or silencing ERR&ggr;. Altogether, these results suggest that HIF-1α can positively regulate the dopaminergic phenotype through ERR&ggr;. This study could provide new perspectives for understanding the mechanisms underlying the promotion of dopaminergic neuronal differentiation by hypoxia.
Enhanced Light Outcoupling in Organic Light-Emitting Diodes Using Phase Separated Polymer Films
Juhee Hong,Joo Won Han,Trang T. K. Tu,Soyeon Kim,Dongchan Lim,Sung Bin Park,Souk Yoon Kim,Jung Ha Kim,Dong Woo Kim,Jonghee Lee,Kwon Taek Lim,김용현 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.4
We report high performance internal light outcoupling films based on phase separation polymer for indium tin oxide-free organic light emitting diodes (OLEDs). The two immiscible polymers of poly(amic acid) and polyimide in a blend film result in nanoporous structures after spin-coating by self-assembly process. The OLEDs are prepared by solution process including phase separation films and transparent electrodes, allowing for low-cost and high-speed manufacturing. The phase separation films prepared between the glass substrate and the poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) transparent electrode remarkably improve the outcoupling performance of OLEDs. The poly(methyl methacrylate) (PMMA)-assisted phase separation films significantly improve the external quantum efficiency and power efficiency of OLEDs by a factor 1.88 and 1.87, respectively, compared to the reference device without any outcoupling structure. Our results demonstrate that phase separation films developed here offer new opportunities in improving the outcoupling efficiency in OLEDs.
Lim, Juhee,Bang, Yeojin,Choi, Jong-Hyun,Han, Arum,Kwon, Min-Soo,Liu, Kwang Hyeon,Choi, Hyun Jin Society for Neuroscience 2018 The Journal of neuroscience Vol.38 No.7
<P>Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD). The neuropathology of LRRK2 mutation-related PD, including increased dopaminergic neurodegeneration and Lewy bodies, is indistinguishable from that of idiopathic PD. The subtle nonmotor phenotypes of LRRK2 mutation-related PD have not been fully evaluated. In the present study, we examined anxiety/depression-like behaviors and accompanying neurochemical changes in differently aged transgenic (Tg) mice expressing human mutant LRRK2 G2019S. Through multiple behavioral tests, including light-dark test, elevated plus maze, sucrose preference test, forced swimming test, and tail-suspension test, we found that anxiety/depression-like behavior appeared in middle-aged (43-52 weeks) Tg mice before the onset of PD-like motor dysfunction. These behavioral tests were performed using both male and female mice, and there were no sex-related differences in behavioral changes in the middle-aged Tg mice. Along with behavioral changes, serotonin levels also significantly declined in the hippocampus of Tg mice. Additionally, increases in the expression of the 5-HT1A receptor (5-HT1AR) grew more significant with aging and were detected in the hippocampus, amygdala, and dorsal raphe nucleus. In vitro study using the serotonergic RN46A and hippocampal HT22 cells showed that 5-HT1AR upregulation was related to enhanced expression of LRRK2 G2019S and was attenuated by the LRRK2 inhibitor LRRK2-IN-1. Wild-type LRRK2 had no significant effect on 5-HT1AR transcription. The present study provides the first in vivo and in vitro evidence demonstrating abnormal regulation of 5-HT1AR along with the manifestation of anxiety/depression-like, nonmotor symptom in PD related to LRRK2.</P>