http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mao, Juan,Won, Sung Wook,Yun, Yeoung-Sang American Chemical Society 2013 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.52 No.19
<P>Anionic polymer, poly(acrylic acid) (PAA), was chemically attached onto the surface of Corynebacterium glutamicum biomass in order to introduce plenty of binding sites for cationic metals. In addition, to reinforce the mechanical strength of PAA-modified biomass (PAAB), it was cross-linked with glutaraldehyde (GA), referred as PAAB-G. Cd(II) was chosen as a model cationic pollutant in this work. FTIR and SEM were used to characterize PAAB-G. pH edge experiments revealed that Cd(II) biosorption was favored at pH 6. According to the Langmuir model, PAAB-G recorded the maximum Cd(II) uptake of 139.8 mg g<SUP>–1</SUP>, with 3.2 times enhancement comparing that for raw biomass. Kinetic experiments showed that equilibrium was quickly obtained within 10 and 30 min for the raw biomass and PAAB-G, respectively. Desorption studies indicated that Cd-loaded PAAB-G could be easily eluted by adjusting water solution to pH 2.0. Therefore, this simple and cost-effective method for surface modification can be considered as a promising design tool for developing a high-performance biosorbent for removal of cationic metals from aqueous solution.</P>
Mao, Ying-Ying,Jing, Fang-Yuan,Jin, Ming-Juan,Li, Ying-Jun,Ding, Ye,Guo, Jing,Wang, Fen-Juan,Jiang, Long-Fang,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Accumulated evidence has indicated that Ephrin A1 (EFNA1) is associated with angiogenesis and tumorigenesis in various types of malignancies, including colorectal cancer (CRC). In the current study, we performed an online search using the public microarray database to investigate whether EFNA1 expression might be altered in CRC tissues. We then conducted a case-control study including 306 subjects (102 cases and 204 well-matched controls) in Xiaoshan County to assess any association between genetic polymorphisms in EFNA1 and CRC susceptibility. Searches in the Oncomine expression profiling database revealed EFNA1 to be overexpressed in CRC tissue compared with adjacent normal tissue. The rs12904 G-A variant located in the 3' untranslated region (UTR) of EFNA1 was observed to be associated with CRC susceptibility. Compared with the AA homozygous genotype, those carrying GA genotype had a decreased risk of developing CRC (odds ratio (OR)=0.469, 95% confidence interval (CI): 0.225-0.977, and P=0.043). The association was stronger among smokers and tea drinkers, however, no statistical evidence of interaction between rs12904 polymorphism and smoking or tea drinking on CRC risk was found. Our results suggest that EFNA1 is involved in colorectal tumorigenesis, and rs12904 A>G polymorphism in the 3' UTR of EFNA1 is associated with CRC susceptibility. Larger studies and further mechanistic investigations are warranted to confirm our findings.
New Amide N-glycosides of Ansamitocins Identified from Actinosynnema pretiosum
Juan Ma,Pei-Ji Zhao,Yue-Mao Shen 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
By using preparative TLC as the critical isolation procedure, two compounds, including one new amide N-glycosides of ansamitocin (2), were isolated from Actinosynnema pretiosum. The compounds were elucidated as N-demethyl-N-β-D-glucopyranosyl ansamitocin P-2, named ansamitocinoside P-2 (1), and N-demethyl-N-β-D-glucopyranosyl ansamitocin P-1, named ansamitocinoside P-1 (2) on the basis of their spectral data. The 1H-NMR and 13C-NMR assignments were made for 1 and 2 while the 13C-NMR assignment for 1 was revised. Bioassay results showed that 1 had antineoplastic activity.
From Nanodot to Nanowire: Hybrid Au/Titania Nanoarrays by Block Copolymer Templates
Peng, Juan,Mao, Chun,Kim, Jinheung,Kim, Dong Ha WILEY-VCH Verlag 2009 Macromolecular Rapid Communications Vol.30 No.21
<P>A simple scheme to fabricate 2-D arrays of Au/titania hybrid nanopatterns is presented, using polystyrene-block-poly(ethylene oxide) diblock copolymer (PS-b-PEO) as templates coupled with sol–gel chemistry. Both the functionalized Au nanoparticles (NPs) and titania precursors are selectively incorporated into the PEO domain. A series of morphologies ranging from nanodot to nanowire arrays is formed and the mechanism of morphological evolution is discussed. Such hybrid films exhibit characteristic localized surface plasmon resonance bands originating from the coupling between neighboring Au NPs spatially located in a controlled manner.</P><P> <img src='wiley_img/10221336-2009-30-21-MARC200900209-gra001.gif' alt='wiley_img/10221336-2009-30-21-MARC200900209-gra001'> </P> <B>Graphic Abstract</B> <P>A simple route to fabricate 2-D arrays of Au/TiO2 hybrid nanopatterns is presented, using polystyrene-block-poly(ethylene oxide) diblock copolymer as templates coupled with sol–gel chemistry. A series of morphologies ranging from nanodot to nanowire arrays is formed. Such hybrid films exhibit characteristic localized surface plasmon resonance bands originating from the coupling between neighboring Au nanoparticles spatially located in a controlled manner. <img src='wiley_img/10221336-2009-30-21-MARC200900209-content.gif' alt='wiley_img/10221336-2009-30-21-MARC200900209-content'> </P>
New Amide N-glycosides of Ansamitocins Identified from Actinosynnema pretiosum
Ma, Juan,Zhao, Pei-Ji,Shen, Yue-Mao 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
By using preparative TLC as the critical isolation procedure, two compounds, including one new amide N-glycosides of ansamitocin (2), were isolated from Actinosynnema pretiosum. The compounds were elucidated as N-demethyl-N-${\beta}$-D-glucopyranosyl ansamitocin P-2, named ansamitocinoside P-2 (1), and N-demethyl-N-${\beta}$-D-glucopyranosyl ansamitocin P-1, named ansamitocinoside P-1 (2) on the basis of their spectral data. The $^1$H-NMR and $^{13}$C-NMR assignments were made for 1 and 2 while the $^{13}$C-NMR assignment for 1 was revised. Bioassay results showed that 1 had antineoplastic activity.
윤영상,Juan Mao,민지호,원성욱 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.5
The waste biomass generated from mono sodium glutamate fermentation process, Corynebacterium glutamicum, was evaluated as a biosorbent for the removal of Basic Blue 3 (BB 3), as a model cationic dye, from aqueous solution. A series of batch experiments to study pH edge, precipitation of dye, isotherms and kinetics were undertaken. The solution pH was found to be an important factor in biosorption of BB 3. With increasing the pH, the uptake of BB 3 increased, except at a pH below 2. At pH values below 2, the precipitation of BB 3 occurred rather than biosorption, which resulted in overestimation of the sorption performance. The sorption process could reach quickly to equilibrium after 1 min. The Langmuir and Freundlich models were used to fit the experimental data at different pH conditions. Between them, the Langmuir model described the experimental data very well with high correlation coefficients. Furthermore, C. glutamicum was easily eluted by shifting the solution pH, making repeated sorption/desorption cycle (up to 4 times) possible without significant performance decrease
Chun, Jaemoo,Li, Rui-Juan,Cheng, Mao-Sheng,Kim, Yeong Shik Elsevier 2015 Cancer letters Vol.357 No.1
<P><B>Abstract</B></P> <P>The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway. Alantolactone effectively suppressed both constitutive and inducible STAT3 activation at tyrosine 705. Alantolactone decreased STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases. Although SHP-1, SHP-2, and PTEN, which are protein tyrosine phosphatases (PTPs), were not affected by alantolactone, the treatment with a PTP inhibitor reversed the alantolactone-induced suppression of STAT3 activation, indicating that PTP plays an important role in the action of alantolactone. Finally, alantolactone treatment resulted in the inhibition of migration, invasion, adhesion, and colony formation. The <I>in vivo</I> administration of alantolactone inhibited the growth of human breast xenograft tumors. These results provide preclinical evidence to continue the development of alantolactone as a STAT3 inhibitor and as a potential therapeutic agent against breast cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> STAT3 is a transcription factor that is a potent regulator of tumorigenesis. </LI> <LI> Alantolactone suppresses constitutive and inducible STAT3 tyrosine phosphorylation. </LI> <LI> Alantolactone inhibits NF-κB translocation to the nucleus. </LI> <LI> Alantolactone inhibits cell migration, invasion, adhesion, and colony formation. </LI> <LI> Alantolactone inhibits the tumor growth of MDA-MB-231 xenografts in mice. </LI> </UL> </P>