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- 저자 : Joung Whan Moon (검색결과 3 건)
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Joung Whan Moon,Jin Wan An,Yeon Kyun Oh,Du Young Choi,Chang Woo Lee,Seung Taek Yu 조선대학교 의학연구원 2016 The Medical Journal of Chosun University Vol.41 No.4
Diagnosis of scrub typhus is difficult because of its unspecific symptoms. The authors studied the correlation between serum adenosine deaminase (ADA) levels and scrub typhus, with the aim of aiding diagnose of the disease. The medical records of 64 children, who visited Wonkwang University Hospital from 2005 to 2015 for fever of undetermined origin, were analyzed retrospectively. Serum ADA levels were measured and indirect immunofluorescence antibody (IFA) assays were conducted. The patients were divided into two groups based on diagnosis of scrub typhus. Of 64 febrile patients, 39 were confirmed to have scrub typhus. Mean serum ADA level in the scrub typhus group (58.54±2.82 IU/L) was significantly higher than that in the non-scrub typhus group (29.30±4.03 IU/L, p<0.05). In the 25 non-scrub typhus patients, mean serum ADA level was significantly higher (50.24±8.52 IU/L) in patients with Mycoplasma infection than that in those with other diseases (19.46±1.39 IU/L, p<0.05). The study shows that in patients with only fever who are difficult to diagnose, serum ADA levels substantially aid the diagnosis of scrub typhus. Ed:- please consider carefully
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김완수,김영태,조문균,이종석,황규왕 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.1
During pregnancy profound immunologic, metabolic, endocrine, and vascular changes occur. Because of these changes, some diseases are affected by pregnancy. These diseases can aggravate or improve during pregnancy. Lymphomatoid papulosis is a continuing self-healing eruption whose lesions are clinically benign but histologically contain malignant-appearing cells. We report a case of lymphomatoid papulosis which developed in 30-year-old pregnant woman. And we discussed the possible association between lymphomatoid papulosis and pregnancy. (Korean J Dermatol 2004;42(1):80~83)
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Im, Chang-Nim,Kim, Byeong Mo,Moon, Eun-Yi,Hong, Da-Won,Park, Joung Whan,Hong, Sung Hee Korea Genome Organization 2013 Genomics & informatics Vol.11 No.4
A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.
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