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- 저자 : José Ríos (검색결과 3 건)
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Salvatore Rudilosso,José Ríos,Alejandro Rodríguez,Meritxell Gomis,Víctor Vera,Manuel Gómez-Choco,Arturo Renú,Núria Matos,Laura Llull,Francisco Purroy,Sergio Amaro,Mikel Terceño,Víctor Obach,Joaquim Se 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.3
Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups’ criteria). Results Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Conclusions Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.
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Dávalos Enrique,Enciso José-Luis,Silva Nicolás,Pinto-Ríos Juan,Leiva Ariel 한국통신학회 2023 ICT Express Vol.9 No.5
Bandwidth fragmentation is a critical problem for Elastic Optical Networks (EON), and spectrum defragmentation is the most important strategy to mitigate this phenomenon. In this work we propose a Machine Learning (ML) based method for estimating the Blocking Rate, which, when exceeding a threshold, triggers a defragmentation process. This is done in order to achieve better results in terms of the number of blocking demands and the number of re-routed connections. The performance of the proposed method was compared with two other known strategies: fixed-time (FT) defragmentation, and triggering based on one fragmentation metric (BFR). Simulation results were evaluated using two multi-objective metrics. Experimental results show that the proposed method is more efficient than the other two, being the best method in 85.7% of comparisons using the Pareto Coverage metric, and obtaining 47.4% of non-dominated solutions in the Pareto Front.
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Expression of heat shock protein genes in Simmental cattle exposed to heat stress
Guzmán Luis Felipe,Martínez-Velázquez Guillermo,Villaseñor-González Fernando,Vega-Murillo Vicente Eliezer,Palacios-Fránquez José Antonio,Ríos-Utrera Ángel,Montaño-Bermúdez Moisés 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.5
Objective: In tropical, subtropical and arid zones, heat stress is the main cause of productivity reduction in cattle. When climate stressors occur, animals become thermal adapted through differential expression of some genes, including heat shock proteins (HSP) family. The aim of this study was to determine levels of expression of HSP60, HSP70, and HSP90 genes in Simmental cattle raised in tropical environments of Mexico. Methods: In this study, expression of HSP60, HSP70, and HSP90 genes was analyzed in 116 Simmental cattle from three farms with tropical climate located in western Mexico. Animals were sampled twice a day, in the morning and noon. Gene expression was evaluated by quantitative polymerase chain reaction using probes marked with fluorescence. The MIXED procedure of SAS with repeated measures was used for all statistical analysis. Results: HSP60 gene expression differences were found for sex (p = 0.0349). HSP70 gene differences were detected for sampling hour (p = 0.0042), farm (p<0.0001), sex (p = 0.0476), and the interaction sampling hour×farm (p = 0.0002). Gene expression differences for HSP90 were observed for farm (p<0.0001) and year (p = 0.0521). HSP70 gene showed to be a better marker of heat stress than HSP60 and HSP90 genes. Conclusion: Expression of HSP70 gene in Simmental herds of the tropical region of western México was different during early morning and noon, but the expression of the HSP60 and HSP90 genes was similar. Identification of resilient animals to heat stress will be useful in the genetic improvement of the Simmental breed.
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