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이화운,김유근,정우식,오은주,임헌호,노순아,반수진,최현정,김민선,김헌숙 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-
In the view of the results investigated the effect of air pollutants that is emitted from a new generator facilities, the total estimated concentration which is the summation of a contributional concentration and observational concentration is much less than that of atmospheric environment criterion for the air pollutants. So we can predict that the operation of the new generator facilities with mitigation equipment don't seriously affect around environment. At the same time, we compared the contributional concentration of before mitigation equipment with that of after it to examine the decreasing amount due to mitigation equipment. The result showed that the concentration of SO2, NO2 and PM-10 is reduced to 25%, 30% and 26% of original value, respectively.
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이주헌(Joo Heon Lee),노주헌(Joo Heon Roh) 대한안과학회 2022 대한안과학회지 Vol.63 No.11
목적: 윗눈꺼풀에 발생한 피부뿔이 동반된 각질가시세포종을 경험하였기에 이를 보고하고자 한다. 증례요약: 59세 여자 환자가 우측 윗눈꺼풀에 발생한 종괴를 주소로 내원하였다. 통증 없이 크기가 빠르게 커지는 양상을 보였다고하였다. 내원 당시 우안 윗눈꺼풀 중앙에 2×2×5 mm 크기의 원뿔모양 암갈색 덩이가 돌출되어 있었으며, 기저부에 7×4 mm의 융기된 결절이 관찰되었다. 진단을 위해 절제생검하였으며, 절제된 종괴는 주변 조직과 유착되어 있어 가능한 완전절제를 시행하였다. 절제된 원뿔형 종괴에서는 이상각화증과 과각화증이 관찰되었고, 결절 형태의 종괴에서는 각질마개, 각질진주, 편평상피세포의 증식이 관찰되었다. 이러한 소견으로 눈꺼풀에 발생된 피부뿔을 동반한 각질가시세포종으로 진단하였다. 결론: 눈꺼풀에 발생하는 각질가시세포종은 피부뿔을 동반하기도 하며 편평상피세포암종과 임상 및 병리학적으로 감별해야 할 질환으로써, 수술적 절제 및 조직병리검사를 고려해야 한다. Purpose: To report a case of upper eyelid keratoacanthoma with a cutaneous horn. Case summary: A 59-year-old female presented to our clinic with a rapidly growing, painless mass in the center of the right upper eyelid. A 2 × 2 × 5 mm dark brown conical hyperkeratotic mass and a 7 × 4 mm nodular, nontender mass were palpable on the right upper eyelid. The lesion was isolated from the surrounding tissues and excised completely. Histopathologically, the excised masses showed parakeratosis along with hyperkeratosis of the conical mass and the keratin plug, keratin pearls, and epithelial proliferation in the nodular mass. These findings led to a diagnosis of eyelid keratoacanthoma with a cutaneous horn. Conclusions: Eyelid keratoacanthomas may be accompanied by cutaneous horns and confused with squamous cell carcinomas. The treatment is complete excision, which should be followed by histopathological analysis.
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양헌(Heon Yang),노주헌(Joo Heon Roh) 대한안과학회 2017 대한안과학회지 Vol.58 No.1
목적: 눈꺼풀에 국한하여 발생하는 신경집종은 매우 드문 질환이다. 저자들은 콩다래끼와 유사한 형태로 발생한 증례가 있어 이를 보고하는 바이다. 증례요약: 54세 남자가 재발된 우안 윗눈꺼풀의 종괴를 주소로 내원하였다. 과거력상 환자는 2년 전 개인 안과에서 콩다래끼로 진단받고 절개술을 시행 받은 병력이 있으며, 종괴는 절개 후 재발하여 2년 동안 통증 없이 크기가 천천히 커지는 양상을 보였다. 내원 당시 우안 윗눈꺼풀 가운데에 4 × 3 mm의 단단한 비색소성 눈꺼풀 종괴가 관찰되었으며, 신경섬유종증과 같은 전신질환은 없었다. 진단을 위해 국소마취하에 종괴를 절제 생검하였으며, 종괴는 경계가 분명하였고 주변과 잘 박리되었다. 절제된 종괴는 조직병리검사상 방추세포들이 울타리 배열의 베로케이 소체를 구성하는 모습을 보였고, 면역조직화학염색상 S-100 단백질에 대하여 미만성의 강한 양성 소견을 보였다. 이러한 소견으로 눈꺼풀에 발생한 신경집종으로 진단하였다. 결론: 눈꺼풀에 발생하는 신경집종은 매우 드물지만 콩다래끼와 유사한 양상을 보이는 경우가 있어 간과하기 쉽다. 따라서 본 증례와 같이 불완전한 절제 후 다시 느리게 자라나거나 악성 변형이 의심되는 종괴는 감별진단 시 신경집종도 고려할 필요가 있다. Purpose: To report a rare case of upper eyelid schwannoma presenting as a chalazion. Case summary: A 54-year-old male presented to our clinic with a slowly growing, painless recurred mass located in the middle area of the right upper eyelid margin. Surgical incision had been performed on a similar mass two year previous, although no histological analysis had been performed. On examination, a 4 × 3-mm-sized, firm, nonpigmented mass was palpable in the right upper eyelid, and no signs of neurofibromatosis were present elsewhere. The lesion was initially thought to be an eyelid mass, so we performed an excisional biopsy under local anesthesia. The lesion was easily isolated from the surrounding tissue and was excised completely. Histopathologically, the excised mass showed a compact arrangement of spindle cells forming palisades with Verocay bodies (Antoni A patterns). Immunohistochemistry revealed diffuse and strong S-100 protein positivity. These findings resulted in the diagnosis of eyelid schwannoma. Conclusions: Because of its rarity and solitary feature, eyelid schwannoma can be confused with chalazion. Thus, ophthalmologists should consider schwannoma in the differential diagnosis of a slowly growing, painless recurred mass or a lesion with malignant transformation after incomplete excision.
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Kim, Lee Kyung,Roh, Eun,Kim, Min Joo,Kim, Min Kyeong,Park, Kyeong Seon,Kwak, Soo Heon,Cho, Young Min,Park, Kyong Soo,Jang, Hak Chul,Jung, Hye Seung John Wiley & Sons Ltd 2016 Journal of diabetes investigation Vol.7 No.6
<P><B>Abstract</B></P><P><B>Aims/Introduction</B></P><P>Glycemic variability is known to induce oxidative stress. We investigated the relationships between glycemic variability and serum bilirubin levels, an endogenous anti‐oxidant, in patients with diabetes.</P><P><B>Materials and Methods</B></P><P>A cross‐sectional study was carried out with 77 patients with type 2 diabetes who had been recruited to two clinical studies from 2008 to 2014. There were no participants with diseases of the pancreas, liver, biliary tract and chronic renal insufficiency. Glycemic variation was calculated by a continuous glucose monitoring system, and correlation analyses were carried out to evaluate their association with bilirubin levels. Multiple linear regression was carried out to identify independent factors influencing bilirubin levels and glycemic variation.</P><P><B>Results</B></P><P>Among the participants, 42.3% were men. The mean (standard deviation) age was 61.5 years (10.4 years), body mass index was 24.2 kg/m<SUP>2</SUP> (2.8 kg/m<SUP>2</SUP>), diabetes duration was 17.7 years (9.5 years), hemoglobin A<SUB>1c</SUB> was 60.7 mmol/mol (7.1 mmol/mol; 7.7 [0.7]%) and bilirubin was 11.8 μmol/L (4.10 μmol/L). Serum bilirubin levels were not different according to age, body mass index and hemoglobin A<SUB>1c</SUB>. However, the mean amplitude of glucose excursion was positively associated with bilirubin levels in women (<I>r</I> = 0.588, <I>P</I> < 0.001). After adjustment with duration of diabetes, serum albumin, liver enzymes, and mean glucose, the correlation between bilirubin and mean amplitude of glucose excursion remained significant (<I>r</I> = 0.566, <I>P</I> < 0.001). Multiple linear regression analyses showed that bilirubin was an independent determinant for the mean amplitude of glucose excursion in women. 1,5‐Anhydroglucitol was also associated with bilirubin levels in women.</P><P><B>Conclusions</B></P><P>Bilirubin level within the physiological range might be an independent predictor for glycemic variability in women with type 2 diabetes.</P>
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Overlooked KCNQ4 variants augment the risk of hearing loss
Oh Kyung Seok,Roh Jae Won,Joo Sun Young,Ryu Kunhi,Kim Jung Ah,Kim Se Jin,Jang Seung Hyun,Koh Young Ik,Kim Da Hye,Kim Hye-Youn,Choi Murim,Jung Jinsei,Namkung Wan,Nam Joo Hyun,Choi Jae Young,Gee Heon Yu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Pathogenic variants of KCNQ4 cause symmetrical, late-onset, progressive, high-frequency-affected hearing loss, which eventually involves all frequencies with age. To understand the contribution of KCNQ4 variants to hearing loss, we analyzed whole-exome and genome sequencing data from patients with hearing loss and individuals whose hearing phenotypes were unknown. In KCNQ4, we identified seven missense variants and one deletion variant in 9 hearing loss patients and 14 missense variants in the Korean population with an unknown hearing loss phenotype. The p.R420W and p.R447W variants were found in both cohorts. To investigate the effects of these variants on KCNQ4 function, we performed whole-cell patch clamping and examined their expression levels. Except for p.G435Afs*61, all KCNQ4 variants exhibited normal expression patterns similar to those of wild-type KCNQ4. The p.R331Q, p.R331W, p.G435Afs*61, and p.S691G variants, which were identified in patients with hearing loss, showed a potassium (K+) current density lower than or similar to that of p.L47P, a previously reported pathogenic variant. The p.S185W and p.R216H variants shifted the activation voltage to hyperpolarized voltages. The channel activity of the p.S185W, p.R216H, p.V672M, and p.S691G KCNQ4 proteins was rescued by the KCNQ activators retigabine or zinc pyrithione, whereas p.G435Afs*61 KCNQ4 proteins were partially rescued by sodium butyrate, a chemical chaperone. Additionally, the structure of the variants predicted using AlphaFold2 showed impaired pore configurations, as did the patch-clamp data. Our findings suggest that KCNQ4 variants may be overlooked in hearing loss that starts in adulthood. Some of these variants are medically treatable; hence, genetic screening for KCNQ4 is important.
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비 내시경적 조대술로 치료한 사골동기원 안와낭종 치험 1례 : Treated by Nasal Endoscopic Marsupialization.
권신재,노주헌,이봉희 고신대학교 의학부 1997 高神大學校 醫學部 論文集 Vol.12 No.1-2
The mucocele is originated from the paranasal sinus, and commonly occured, following the dermoid cyst in frequency. The etiology is controversial, but they are thought to result from local obstruction of a sinus ostium. Most cases take the benign course. In the past, the optimal treatment of mucocele are radical operations, which is complete removal of all mucous membrane within the sinus, subsequent obliteration or collapsing, and maintaining the opening site of the sinus. But recently, nasal endoscopic drainage of orbital mucocele affords the potential for dramatically reducing operative morbidity of surgery, minimal bleeding and short operative time. Also following surgery, direct endoscopic visualization of the area enables accurate follow-up. The authors experienced a case of the mucocele which suspect that it originated from the ethmoidal sinus by considering its clinical features and orbital CT, and have been encouraged with treating it by the nasal endoscopic marsupialization. And so we report that endoscopic approach marsupialization appears to be good alternative for the treatment of orbital mucocele.
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