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손주환,온두현 全北大學校 1969 論文集 Vol.11 No.-
By the use of acetophenone containing P-toluene sulfonic acid, myoinositol have been converted into 1,2-0-(1-phenyl ethylidene) myoinositol. This Compound is important intermediate for stereochemical work. The preparation of 1, 4, 5, 6-0-acetylmyoinositol in good yield and the structure is described.
孫周煥,任齊彬 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.3
느릅나무 粘液의 液性은 처음에는 中性이나 酸性으로 變한 다음 中性에 가까워지는 經時的 變化가 일어나며 粘液의 粘度低下는 黃蜀葵根 粘液 매우 緩慢하다. 또 이것은 遊離 還元糖을 含有하고 含量은 經時的으로 變化하여 처음에는 增加한 다음 急激하게 減少하며 糖含量과 粘度와의 사이에서 分明한 比例關係를 찾아볼 수는 없다. 糖類를 經詩的으로 分析한 結果 黃蜀葵根 粘液과는 달리 glucose 및 galacturonic acid等 2種의 糖類가 검출되었다. 그러나 粘質物의 加水分解 生成物에서 檢出된 糖類는 rhamnose, mannose, galactose, arabinose 그리고 galacturonic acid 等이며 黃蜀葵根 粘質物에서 檢出되었던 xylose는 檢出되지 아니하고 mannoserk 檢出되었다. The changes of hydrogen ton concentration, viscosity and free sugars in the water-soluble mucilage of Ulmus Coreana, Nakai root upon storage at 10℃ were studied, Hydrogen ion concentration in the mucilage changed pH7→pH4→pH6 or 7. The viscosity of mucilage decreased very slowly. The mucilage contained glucose and galacturonic acid. The hydrolyzed products of mucilage consisted of rhamnose, mannose, galactose, arabinose, xylose, glucose and galacturonic acid.
두경부 종양세포주에 대한 Mithramycin A의 세포자멸사 유도성 및Cisplatin 항암작용 증가효과
이강대,손성환,박종욱,김영록,이봉주,김주연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Background and Objectives : Cisplatin (CP) is a major chemotherapeutic agent for head and neck cancer. However, cancer cells can get drug resistance through recovering the DNA damage by CP. Mithramycin A (MA) can inhibit gene expression of multidrug resistance gene 1, c-myc or h-ras. The goal of this study is to evaluate the therapeutic effect of MA alone and combination of MA and CP on head and neck cancer cell lines. Materials and Methods : Two head and neck cancer cell lines (AMC-HN4, AMC-HN7) were treated with MA. The cellular proliferation, apoptosis and protein expression were measured with XTT assay, FACS analysis, and western blotting, respectively after MA treatment in cell lines. In order to know the combination effect of MA with CP, the cancer cell lines were treated with MA, CP, and MA/CP combination, and cellular proliferation, apoptosis and expression of apoptosis-associated proteins were measured. Results : MA inhibited the proliferation of head and neck cancer cells and induce dapoptosis. Increase of caspase activation, PLC-?1 fragmentation and percent apoptosis by MA treatment was blocked by z-VAD-fms, but not blocked by N-Acetyl Cystein. Combination of MA and CP significantly inhibited cancer cell growth and increased apoptosis compared to MA and CP alone, and it also suppressed the expression of anti-apoptotic proteins such as XIAP and Mcl-1. Conclusions : The present study suggests that MA alone andMA/CP combination chemotherapy could be a potential regiment for the control of the head and neck cancer.
2 - 아미노나프탈렌술폰산류의 자외선분광 광도법에 의한 분석
Sohn Joo Hwan(孫周煥),Kim Joo Youn(金宙元) 한국유화학회 1986 한국응용과학기술학회지 Vol.3 No.2
The sulfuric acid sulfonation mixtures of 2-aminonaphthalene, contained 2-aminonaphthalene, Dahl s acid, Broenner s acid, amino-F-acid and Baden acid, can be determined quantitatively by multicomponent spectrophotometric analysis. The analysis was performed in diluted sodium hydroxide aqueous solution and based on the ultraviolet absorption of the sodium salts of each isomers. The determination of quantity of each isomers was performed by subjection the absorbances of the unknown mixture and of its constituents, gathered at a large number of wavelengths, to a least square treatment by an electronic personer computer. This method provided a rapid analysis of such complex mixture, and the standard deviation was ±1.65 mole %.
Sohn, Eunjin,Kim, Junghyun,Kim, Chan-Sik,Lee, Yun Mi,Jo, Kyuhyung,Shin, So Dam,Kim, Joo Hwan,Kim, Jin Sook Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Increasing evidence indicates that advanced glycation end products (AGEs) contribute to the pathogenesis of diabetic nephropathy. The aim of this study was to investigate the protective effect of <I>L. japonica</I> extract (LJE) against renal damage in the db/db mouse. LJE (100 or 250 mg/kg per day) was given to diabetic mice for 12 weeks. Body weight, blood glucose levels, glycated hemoglobin (HbA1c) levels, and proteinuria were examined. In <I>in vitro</I> assay of the inhibition of AGE formation, immunohistochemical analysis of podocyte loss and AGE accumulations were performed. In 20-week-old db/db mice, severe hyperglycemia developed, and proteinuria was significantly increased. Diabetes induced markedly morphological alterations to the renal glomerular cells. AGE accumulations and podocyte loss were detected in renal glomeruli. LJE treatment significantly reduced proteinuria and AGE accumulations in diabetic mice. Moreover, the loss of nephrin, an important slit diaphragm component in the kidneys, was restored by LJE treatment. Our studies suggest that LJE might be beneficial for the treatment of diabetic nephropathy. The ability of LJE to attenuate proteinuria and podocyte dysfunction may be mediated by the inhibition of AGE accumulation in the context of diabetic nephropathy in db/db mice.</P>
카르복시 베타인 유도체의 합성 및 계면활성에 관한 연구
손주환,김권일,남기대,김유옥 한국유화학회 1986 한국응용과학기술학회지 Vol.3 No.1
1-(carboxyalkyl) trimethyl ammonium chlorides such as 1-(carboxyundecyl) trimethyl ammonium chloride and 1-(carboxytridecyl) trimethyiammonium chloride were synthesized by the reaction of abromoalkanoic acid with trimethyl amine hydrochloride. In other hand, (carboxymethyl) alkyl dimethyl ammonium chlorides such as (carboxymethyl) dodecyl dimethyl ammonium chloride and (carboxymethyl) tetradecyl dimethyl ammonium chloride were synthesized by the reaction of alkyl dimethylamine with sodium chloroacetate. The four kinds of alky carboxy betaine such as 2-(trimethylammonio) dodecanoate, 2-(trimethyl ammonio) tetradecanoate, (dodecyl dimethylammonio) ethanoate and (tetradecyl dimethyl ammonio) ethanoate were prepared from 1-(carboxyalkyl) trimethyl ammonium chlorides or (carboxymethy1) alkyl dimethyl ammonium chlorides. The surface activities including surface tension, emulsifying power, foaming power, foam stability, deflocculating effect, effectiveness of wettability and solubilizing effect were measured and also critical micelle concentration and hydrophilic-lipophilic. balance(HLB) were evaluated. These carboxy betaines show good surface activities as O/W type emulsifing agent and detergent.
황촉규근(黃蜀葵根) 점액에 관한 연구 : [제2보] 점액내 당류의 검색 [Part Ⅱ] Detection of Sugars in the Mucilage
손주환,온두현,임제빈 한국농화학회 1976 Applied Biological Chemistry (Appl Biol Chem) Vol.19 No.1
When the root of Abelmoschus manihot, MEDIC is stored in the water, the mucilage is extracted. The mucilage has contained some of free reducing sugars. We have investigated the change of free reducing sugars by the Bertrand method and also free reducing sugars are detected by paper chromatography and thin layer chromatography. The mucilage is isolated from the root of Abelmoschus manihot, MEDIC and its chemical components are detected. The mucilage and hydrolyzed products are examined by paper chromatography, thin layer chromatography and tested carbohydrates under the usual way. The results are as follow: 1. The mucilage has contained five kinds of monosaccharides which are rhamnose, xylose, arabinose, glucose, galactose and other three kinds of uronic acids. 2. In the mucilage, glucose is the most changeable sugar and the next are arabinase and galactose. 3. Uronic acids, pylose and rhamnose are remaired comparatively longer than glucose, galactose and arabinose in the mucilage. 4. The hydrolyzed products of mucilage consisted of rhamnose, xylose, arabinose, glucose, gelactose, ribose, some uronic acids and other unknown compounds. The essence of mucilage isolated from the root of Abelmoschus manihot, MEDIC is complex saccharide, glucose and ribose are newly certified. 6. We can guess that the components of the mucilage are rhamnose, xylose, arabinose, glucose, ribose, uronic acids and other unknown compounds.