Repeated Aerosol Delivery of Carboxyl-terminal Modulator Protein Suppresses Tumor in the Lungs of K-<i>ras</i>^LA1Mice

Hwang, Soon-Kyung,Lim, Hwang-Tae,Minai-Tehrani, Arash,Lee, Eun-Sun,Park, Jongmin,Park, Seung Bum,Beck Jr., George R.,Cho, Myung-Haing American Thoracic Society 2009 American journal of respiratory and critical care Vol.179 No.12

<P>RATIONALE: Difficulties in achieving long-term survival of patients with lung cancer treated with conventional therapies suggest that novel approaches are required. Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. OBJECTIVES: To investigate the repeated effect of carboxyl-terminal modulator protein (CTMP) on multistage lung tumorigenesis. In this study, we addressed this question by studying the effects of lentivirus-based CTMP in the lungs of 9- and 13-week-old K-ras(LA1) mice, a model of lung cancer. METHODS: An aerosol of lentivirus-based CTMP was delivered into 9- and 13-week-old K-ras(LA1) mice, a model of lung cancer, through a nose-only inhalation system twice a week for 4 weeks. The effects of CTMP on lung cancer progression and Akt-related signals were evaluated. MEASUREMENTS AND MAIN RESULTS: Long-term repeated delivery of CTMP effectively reduced tumor progression in the lungs at different stages of development. Lentiviral-CTMP inhibited protein synthesis and cell cycle and altered Akt signaling pathway in the lungs of 9-week-old K-ras(LA1) mice, and increased apoptosis was observed in the lungs of 13-week-old K-ras(LA1) mice. CONCLUSIONS: Long-term repeated viral delivery of CTMP may provide a useful tool for designing lung tumor treatment.</P>

Can Artemisinin Be a Game Changer Even as an Antiarrhythmic Drug?

Jongmin Hwang 대한심장학회 2023 Korean Circulation Journal Vol.53 No.4

Assessing Accuracy of Wrist-Worn Wearable Devices in Measurement of Paroxysmal Supraventricular Tachycardia Heart Rate

Jongmin Hwang,Jun Kim,Kee-Joon Choi,Min Soo Cho,남기병,You-Ho Kim 대한심장학회 2019 Korean Circulation Journal Vol.49 No.5

Background and Objectives: Wrist-worn wearable devices provide heart rate (HR) monitoring function via photoplethysmography technology. Recently, these devices have been used by patients to measure the HR when palpitation occurs, but few validation studies of these instruments have been conducted. We assessed the accuracy of these devices for measuring a HR. Methods: This study enrolled 51 consecutive patients with a history of paroxysmal supraventricular tachyarrhythmia (SVT) or paroxysmal palpitations who were scheduled to undergo an electrophysiological study (EPS). Three devices were assessed: Apple Watch Series 2 (Apple), Samsung Galaxy Gear S3 (Galaxy), and Fitbit Charge 2 (Fitbit). Patients were randomly assigned to wear 2 different devices. The HR at baseline and induced SVT were measured during the EPS. After successful ablation of SVT, HR measurements was also done during atrial and ventricular pacing study. Results: The mean patient age was 44.4±16.6 years and 27 patients were male (53%). The accuracy (within ±5 beats per minute [bpm] of an electrocardiogram [ECG] measurement) of the baseline HR measurements was 100%, 100%, and 94%, for Apple, Galaxy, and Fitbit, respectively. The HR during induced SVT ranged from 108 bpm to 228 bpm and the accuracy (within ±10 bpm of an ECG) was 100%, 90%, and 87% for the Apple, Galaxy, and Fitbit, respectively. During pacing study, accuracy of these devices was also acceptable but tended to decrease as the HR increased, and showed differences between the devices. Conclusions: Wrist-worn wearable devices accurately measure baseline and induced SVT HR.

One-Pot Synthesis of Tin-Embedded Carbon/Silica Nanocomposites for Anode Materials in Lithium-Ion Batteries

Hwang, Jongkook,Woo, Seung Hee,Shim, Jongmin,Jo, Changshin,Lee, Kyu Tae,Lee, Jinwoo American Chemical Society 2013 ACS NANO Vol.7 No.2

<P>We report a facile “one-pot” method for the synthesis of Sn-embedded carbon–silica (CS) mesostructured (nanostructured) composites through the selective interaction of resol (carbon precursor), tetraethylorthosilicate (TEOS), and tributylphenyltin (Sn precursor) with an amphiphilic diblock copolymer, poly(ethylene oxide-<I>b</I>-styrene), PEO-<I>b</I>-PS. A unique morphology transition from Sn nanowires to spherical Sn nanoparticles embedded in CS framework has been obtained. Metallic Sn species are homogeneously embedded in a rigid CS framework and are effectively confined within the nanostructures. The resulting composites are used as anode materials for lithium-ion batteries and exhibit high specific capacities (600 mA h g <SUP>–1</SUP> at a current density of 45 mA g<SUP>–1</SUP>, and 440 mA h g<SUP>–1</SUP> at a current density of 300 mA g<SUP>–1</SUP>) and an excellent cyclability of over 100 cycles with high Coulombic efficiency. Most of all, the novel method developed in this work for synthesizing functional hybrid materials can be extended to the preparation of various functional nanocomposites owing to its versatility and facileness.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-2/nn303570s/production/images/medium/nn-2012-03570s_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn303570s'>ACS Electronic Supporting Info</A></P>

Size-controlled SiO2nanoparticles as scaffold layers in thin-film perovskite solar cells

Hwang, Sun Hye,Roh, Jongmin,Lee, Jungsup,Ryu, Jaehoon,Yun, Juyoung,Jang, Jyongsik The Royal Society of Chemistry 2014 Journal of Materials Chemistry A Vol.2 No.39

<P>Perovskite-based solar cells have received much recent research attention for renewable-energy applications because of their high efficiency and long-term stability. Here, we report perovskite solar cells formed using a scaffold layer composed of size-controlled SiO2nanoparticles (NPs). The infiltration of perovskite into the scaffold layer depended strongly on the size of the SiO2NPs. We investigated the effects of scaffold layers comprised of SiO2NPs that were 15, 30, 50, 70, and 100 nm in diameter on the properties of perovskite films. The performance of perovskite solar cells based on 50 nm diameter SiO2NPs exhibited a current density (<I>J</I>sc) of 16.4 mA cm<SUP>−2</SUP>, a open-circuit voltage (<I>V</I>oc) of 1.05 V, and a power-conversion efficiency (PCE) of 11.45%, which represent a significant improvement compared with perovskite solar cells fabricated using a TiO2scaffold layer, where<I>J</I>sc= 17.3 mA cm<SUP>−2</SUP>,<I>V</I>oc= 0.94 V, and the PCE was 10.29%.</P>

Design of square-shaped beam homogenizer for petawatt-class Ti:sapphire amplifier

Hwang, Seungjin,Kim, Taeshin,Lee, Jongmin,Yu, Tae Jun The Optical Society 2017 Optics express Vol.25 No.9

Immobilization and stabilization of subtilisin Carlsberg in magnetically-separable mesoporous silica for transesterification in an organic solvent

Hwang, Ee Taek,Lee, Byoungsoo,Zhang, Meiling,Jun, Seung-Hyun,Shim, Jongmin,Lee, Jinwoo,Kim, Jungbae,Gu, Man Bock The Royal Society of Chemistry 2012 GREEN CHEMISTRY Vol.14 No.7

<P>Subtilisin Carlsberg (SC) was immobilized and stabilized on magnetically-separable mesoporous silica (Mag-MSU-F) in the form of nanoscale enzyme reactors (NERs) based on the ship-in-a-bottle mechanism. Stabilized NERs of SC (NER-SC) were freeze-dried and successfully used for the transesterification of <I>N</I>-acetyl-<SMALL>L</SMALL>-phenylalanine ethyl ester with <I>n</I>-propanol in isooctane. Magnetic separation of Mag-MSU-F facilitated the repeated usages of stable NER-SC. This is the first demonstration for the use of stable and magnetically-separable NERs in an organic solvent, which has the potential for environmentally-friendly synthesis using enzymes in organic solvents.</P> <P>Graphic Abstract</P><P>Highly-stable and magnetically-separable nanoscale enzyme reactors for enzyme-catalyzed synthetic reactions. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2gc35559k'> </P>

Dual-Functional CeO₂:Eu³⁺ Nanocrystals for Performance-Enhanced Dye-Sensitized Solar Cells

Roh, Jongmin,Hwang, Sun Hye,Jang, Jyongsik American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.22

<P>Single-crystalline, octahedral CeO<SUB>2</SUB>:Eu<SUP>3+</SUP> nanocrystals, successfully prepared using a simple hydrothermal method, were investigated to determine their photovoltaic properties in an effort to enhance the light-harvesting efficiency of dye-sensitized solar cells (DSSCs). The size of the CeO<SUB>2</SUB>:Eu<SUP>3+</SUP> nanocrystals (300–400 nm), as well as their mirrorlike facets, significantly improved the diffuse reflectance of visible light. Excitation of the CeO<SUB>2</SUB>:Eu<SUP>3+</SUP> nanocrystal with 330 nm ultraviolet light was re-emitted via downconversion photoluminescence (PL) from 570 to 672 nm, corresponding to the <SUP>5</SUP>D<SUB>0</SUB> → <SUP>7</SUP>F<SUB>J</SUB> transition in the Eu<SUP>3+</SUP> ions. Downconversion PL was dominant at 590 nm and had a maximum intensity for 1 mol % Eu<SUP>3+</SUP>. The CeO<SUB>2</SUB>:Eu<SUP>3+</SUP> nanocrystal-based DSSCs exhibited a power conversion efficiency of 8.36%, an increase of 14%, compared with conventional TiO<SUB>2</SUB> nanoparticle-based DSSCs, because of the strong light-scattering and downconversion PL of the CeO<SUB>2</SUB>:Eu<SUP>3+</SUP> nanocrystals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-22/am505194k/production/images/medium/am-2014-05194k_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am505194k'>ACS Electronic Supporting Info</A></P>

SmartCon : SmartCon: Smart Context Switching for Fast Storage Devices

Gim, Jongmin,Hwang, Taeho,Won, Youjip,Kant, Krishna Association for Computing Machinery 2015 Acm transactions on storage Vol.11 No.2

분기점 연산 기법: 이질형 분산 데이타베이스 시스템에서의 강제적 지역 충돌을 이용한 새로운 전역 동시성 제어 기법

이종민(JongMin Lee),황종선(Chong-Sun Hwang) 한국정보과학회 1997 정보과학회논문지(B) Vol.24 No.7

지금까지 제안된 "이질형 분산 데이타베이스 시스템"의 전역 동시성 제어를 위한 방법들 중에서, 오직 Optimistic Ticket Method(OTM)만이 지역 자치성을 침해하거나 제한하지 않으면서 이질형 분산데이타베이스 시스템의 전역 직렬화가능성을 보장할 수 있다. 그러나, 이 방법은 전역 부트랜잭션들간에 무조건적인 "강제적 지역 충돌"을 유발하므로, 전역 트랜잭션의 동시성을 제한하고, 많은 철회를 초래한다. 또한, 모든 지역 사이트에서 완료준비된 상태를 제공하는 경우에는 불필요한 전역 직렬화가능성 검증을 수행하여, 부가적인 비용을 유발한다. 뿐만 아니라, 이 방법에서는 제출되는 모든 전역 트랜잭션들에 쓰기 연산을 삽입하므로, 읽기전용의 전역 트랜잭션을 제거한다. 이 논문에서, 우리는 전역 트랜잭션들간의 강제적인 지역 충돌을 사용하면서도 위에서 기술한 문제들을 유발하지 않거나 완화하는 새로운 전역 동시성 제어 방법을 제안한다. 제안하는 방법은 전역 교착상태와 동시성 제어에 따른 전역 트랜잭션의 재시작을 유발하지 않는다. 그리고, 오직 전역 스케줄 상에 순화를 유발할 가능성이 있는 전역 부트랜잭션들에 대해서만 강제적인 지역 충돌을 사용하여, 전역 트랜잭션들간의 부가적인 지역 충돌을 감소시킨다. 또한, 전역 부트랜잭션에 오직 하나의 읽기 연산만을 삽입하므로 읽기전용의 전역 트랜잭션을 제거하지 않는다. Among all the proposed methods for the global concurrency control in the heterogeneous distributed database systems(HDDBSs), only Optimistic Ticket Method(OTM) can ensure the global serializability of HDDBSs without any violation or restriction of the local autonomy. This method, however, reduces concurrency and causes many aborts because it unconditionally incurs forced local conflicts between global subtransactions. Besides, in the HDDBSs where each of all the participating sites provides a prepared-to-commit state, it unnecessarily performs global serializability test, and this causes further reduction of the concurrency and additional overhead. Furthermore, it eliminates the global read-only transactions because it inserts a write operation to each of all the global transactions. This paper presents a new global concurrency control method that resolves or alleviates above-mentioned problems while using forced local conflicts between global transactions. This method does not incur global deadlocks and global restarts, and it reduces additional local conflicts between global transactions because it uses the forced local conflicts between global subtransactions only when they may create a cycle in the global schedule. Furthermore, it does not eliminate global read-only transactions because it inserts only one read operation to each global subtransaction.