일부 시판세치제의 비교치아마모도 및 경과시간에 따른 유효불소농도변화에 관한 연구

장덕수,이병진,배광학,방금석,이원재,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.3

The purpose of this study was to assess relative tooth abrasivity and to measure effective fluoride concentration of dentifrices selling in Korea for help consumer's selection of suitable dentifrice. Assessment of the abrasion on tooth produced by different dentifrices were carried out on bovine teeth in the laboratory and tested by radioactive dentin abrasion method. And total soluble fluoride concentrations within the dentifrices was determined using fluoride ion selective electrode with standard curve obtained from standard solutions of known fluoride concentration. 10 dentifrice samples were stored at 49t for 15 weeks and the measurements were made for each dentifrice in 1 week, 2 weeks, 3 weeks, 13 weeks and 15 weeks and 11 dentifrice samples were stored at 40.6C for 3 weeks and the measurements were made for each dentifrice in 1 week and 3 weeks. Tooth abrasivity of selling dentifrices is suitable for toothbrushing but dentifrice which recommended for patient who have tooth abrasion or erosion was somewhat high abrasivity level. Effective fluoride concentrations of selling dentifrices were maintained generally optimal level. But some dentifrices contaning CaCO_(3), as abrasive were decreased as time elapsed. It was suggested that relative tooth abrasivity must be marked on package and fluoride level should be maintained acceptable level in dentifrices for consumer's selection of suitable dentifrice.

악안면 성장예측 모형개발에 관한 연구 : 6세 어린이의 1년간 악안면성장에 관한 연구

김종배,문혁수,장영일,배광학 대한구강보건학회 1999 大韓口腔保健學會誌 Vol.23 No.2

The purpose of this study was to obtain the data on the maxillofacial growth changes of the Korean six-year-old children in a year to establish the maxillofacial growth prediction model. Dental arch stone models of the 682 students in 1995 and of the same students in 1996 were analysed. The maxillofacial growth changes of the students during one year were found by the analysing the dental arch stone models. The dental arch growth changes in a year were analysed by student t-test and the qunantity of growth per a year of dental arch lengths and widths by paired t-test. The obtained results were as follows: 1. It was found that all dental arch lengths and widths had grown during one year. 2. There is no difference between male and female students in maxillofacial growth changes. 3. Maxilla had grown a little more than Mandible during one year. 4. Dental arch lengths had grown a little more than dental arch widths during one year.

성인대상치간배천회전잇솔질교육방법의 효과에 관한 연구

배광학,문혁수,백대일,김종배 대한구강보건학회 2000 大韓口腔保健學會誌 Vol.24 No.1

This experiment was done to assess the effects of two toothbrushing instruction methods on dental plaque and gingival bleeding. 70 Subjects were male and female adults aged 20-39 years, and divided into two groups. With dentiform, subjects of one group were given repeated toothpick and rolling toothbrushing instruction individually, and then they are directed to brush their teeth according to the method they learned just before. With professional toothbrushing instead of dentiform, subjects of the other group were also given the same instruction. Both groups were instructed two times at the internal of 8 weeks. Presence of disclosed dental plaque and gingival bleeding on probing were recorded before every instruction at the start and 8 weeks, and only recorded without instruction at 16 weeks. The results were as follows: 1. Dental plaque on the buccal proximal surfaces of the group instructed with professional toothbrushing was decreased in the molars and incisors of both jaws, but that of the group instructed with dentiform only in the maxillary molars. 2. Dental plaque on the lingual surfaces of the group instructed with professional toothbrushing was decreased in the maxillary molars and mandibular incisors, but that of the group instructed with dentiform in no pacts. 3. Dental plaque on the buccal surfaces of both grips was decreased in no pants. 4. Gingival bleeding of the buccal papillary sites of the group instructed with professional toothbrushing was decreased in the maxillary molar and mandibular molar and incisor areas, but that of the group instructed with dentiform only in the maxillary incisor area. 5. Gingival bleeding of the buccal papillary sites of the group instructed with professional toothbrushing was deceased in the maxillary premolar and mandibular areas, but that of the group instructed with dentiform only in the maxillary incisor and mandibular premolar and incisor areas. 6. Gingival bleeding of the buccal sites of the group instructed with professional toothbrushing was decreased in the maxillary premolar and mandibular molar and incisor areas, but that of the group instructed with dentiform only in the maxillary molar and mandibular incisor areas. 7. Toothpick and rolling toothbrushing can be instructed with professional toothbrushing, rather than with dentiform.

왁스류가 유중수형크림의 조도에 미치는 영향

김종갑,배봉진,최영욱 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.3

Influences of various waxes on the consistency of cream was investigated by inspections through microscope, rheometer and sensory test. Fatty acids, higher fatty alcohols, hydrocarbons, and some of natural waxes were used in this experiment. Most above waxes showed good state of emulsion at low concentration, but at higher concentration (7.0∼8.0%), they showed not only an unstable emulsion state but also a critical point of content in consistency. At this critical point of content, the consistency of w/o type cream was increased irregularly. So, it could be identified that consistency of a w/o type cream was strongly dependent on kinds and contents of waxes in continuous phase.

시판세치제의 치아마모도에 관한 연구

김종배,문혁수,백대일,한문성,정세환,배광학,최기열 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.3

The purpose of this study was to test the relative abrasivity of domestic dentifrice marketing in Korea. The authors had measured dentifrice abrasivity on dentin of 20 kinds of dentifrice. Assessments of the abrasion on dentin produced by different dentifrices were carried out on extracted teeth in the laboratory and tested by radioactive dentin abrasion(RDA) methods, The radioactive dentin abrasion scores of the dentifrices were determined using the ADA specifications. RDA scores were related to a standard abrasive, dicalcium phosphate, anhydrous(CaHPO4), which was assigned a score of 100 for the RDA method. The RDA scores of the dentifrices tested varied from 7.0 to 119.8. The abrasivity of all tested dentifrices marketing in Korea were acceptable. It was suggested that the dentifrices were divided to 4 groups by their RDA scores to recommend to the public.

NaF CPC 녹차추출액 및 솔잎 추출물을 배합한 구강양치액의 치주질환예방효과와 구취감소효과 및 치아우식증예방효과에 관한 연구

배광학,이병진,장윤경,이병렬,이원재,장덕수,문혁수,백대일,김종배 대한구강보건학회 2001 大韓口腔保健學會誌 Vol.25 No.1

The aim of this study was to assess the effect of mouthrinse products which contained 0.03% sodium fluoride, 0.05% cetylpyridinium chloride(CPC), 0.04% pine leaf extracts and 0.04% green tea extracts. The negative control was distilled water contained no antibacterial agents. The in vivo study used case control, double-blind and crossover design in which 40 healthy subjects aged from 20 to 25 participated. On baseline, subjects received a scaling and polishing to reduce plaque index to 0 and commenced rinsing three times and toothcleansing twice daily. Rinsing time was 30 seconds. Plaque, gingivitis, halitosis and the number of S. mutans(CFU/㎖) were scored at baseline, after 2 weeks, after 4 weeks and after 6 weeks. Plaque and gingivitis were score by index and halitosis by halimeter. To compare the microhardness data of differently stored enamel surfaces the in vitro study used pH Cycling Model. Each 19 bovine enamel specimens were given 17h demineralization, 0.25h immersion in mouthrinse products and control, and 6h remineralization buffer solution for 48h and 96h. Gingivitis, halitosis and S. mutans growth of the mouthrinse group were more reduced significantly than control group at 2 weeks(p<0.05). The microhardness of enamel surfaces were also more decreased in mouthrinse products than in distilled water(p<0.05).

불화나트륨과 자일리톨배합양치액의 법랑질표면미세경도변화와 구취감소효과에 관한 연구

김종배,문혁수,백대일,정세환,배광학 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.2

The microhardness changes of tooth enamel by mouthrinses was investigated in vivo using acrylic mandibular removable appliance. Three different mouthrinses which contained 1) 0.02% NaF 2) 0.05% NaF 3) 0.02% NaF + 10% Xylitol were tested. Early caries-like lesions were created using 0.1M lactic acidsodium hydroxide buffer(pH 4.0). Three enamel specimens with early caries-like lesions were mounted into the recesses of lingual surface of the appliance with sticky wax. 10 subjects wore the appliance for one hour after mouthrinsing two times per day. Each subjects wore the appliance for three separate 7-days period; 0.02% NaF mouthrinse, 0.05% NaF mouthrinse, 0.02% NaF + 10% Xylitol mouthrinse. Suface microhardness were checked by microhardness tester(Shimadzu corporation Model, HMV-2000 No. 33100410, Japan) before and after mouthrinse. In order to evaluate the effect of mouthrinses on reducing halitosis, the author had analysed the volatile sulfur compounds(VSC) in halitosis after the chewing of 0.5gm garlic powder by 10 subjects. Following mouth air sampling immediately after the chewing of garlic powder, subjects used mouthrinses and reevaluated at 5 and 10 minutes after chewing of garlic powder. The evaluation of methylmercaptan in mouth air was done by gas chromatographic technic. The percent change in methylmercaptan concentration of air samples were calculated in relation to values of mouth air sample immediately after chewing of garlic powder. The obtained results were as follows: 1. The change of surface microhardness in 0.02% NaF mouthrinse group did not showed significantly between before and after mouthrinse(P>0.05), but surface microhardness in 0.05% NaF mouthrinse group and in 0.02% NaF and 10% Xylitol mouthrinse group showed significantly between before and after mouthrinse(P<0.05). 2. The change of surface microhardness was higher in 0.05% NaF mouthrinse group and in 0.02% NaF and 10% Xylitol mouthrinse group than in 0.02%NaF mouthrinse group, but there was no significance statistically. 3. The mouthrinse containing 0.02% NaF and 10% Xylitol reduced more methylmercaptan than other experimental mouthrinses at 5 minutes after the chewing of garlic powder (P<0.05).

세포페라존피바로일옥시메칠에스텔의 경구 흡수

김종갑,최승호,최영욱,박기배 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4

Pivaloyloxymethyl ester of cefoperazone was synthesized by treating sodium cefoperazone with chloromethyl pivalate and its chemical structure was determined by spectroscopic trials. The pharmaceutical properties of the ester were investigated to assess its potential as a prodrug of cefoperazone. Cefoperazone pivaloyloxymethyl ester was microbiologically inactive itself in vitro, but hydrolyzed into the parent drug in vivo. After a single oral dose of each drug to rabbits, serum concentrations of cefoperazone were determined by high performance liquid chromatographic assay. The ester showed higher and more sustained blood level than cefoperazone. Therefore, the total area under the serum concentration-time curve of the derivative was 16.8 times larger than that of the parent drug.

피페라실린프탈리딜에스텔의 합성 , 가수분해 및 경구흡수에 관한 연구

김종갑,최승호,최영욱,박기배 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.3

Piperacillin phthalidyl ester was synthesized by reacting piperacillin with triethylamine and bromophthalide in acetone and its chemical structure was determined by UV, IR, and PMR. The partition coefficient of the ester was increased and the ester was more lipophilic and less water soluble than piperacillin. The ester did not show the antimicrobial activity against Bacillus subtilis ATCC 6633 in vitro, but when hydrolyzed, the parent drug of ester, piperacillin, revealed antimicrobial activity in vivo. After a single oral dose of both piperacillin and the ester to rabbits, the serum piperacillin concentration was measured by bioassay. The ester exhibited improved pharmatokinetic characteristics: T_(max) of 2hr, C_(max) of 4.26㎍·㎖^(-1), K_(el) of 0.057hr^(-1), and total AUC of 85.42㎍·hr·㎖^(-1). Piperacillin on the other hand, did not exhibit any gastro-intestinal absorption.

세포페라존프탈리딜에스텔의 약제학적 연구

김종갑,최승호,최영욱,박기배 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.4

A new cephalosporin derivative, cefoperazone phthalidyl ester, were synthesized and investigated in terms of dissolution and absorption properties. In comparison with cefoperazone, its phthalidyl ester showed the following characteristics. The mean dissolution time and variance of retention time were more significantly prolonged in simulated intestinal fluid than those in simulated gastric fluid. After a single oral dosing of both cefoperazone and its ester to rabbits, serum concentrations of cefoperazone were measured by bioassay, and the results showed that the ester exhibited much higher and more sustained blood level than the parent drug. The total area under the curve of cefoperazone phthalidyl ester were 10.8 times greater than that of cefoperazone.