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Syntactic Differences of Plurality Markers
Joh,Yoon-kyoung 한국영미어문학회 2011 영미어문학 Vol.- No.98
There are two crucial syntactic differences found among plurality markers. Dependent plurals and anti-quantifiers work at the phrasal level as opposed to ordinary plurals that apply to the lexical level. More specifically, ordinary plurals are adjoined to the X level while anti-quantifiers attach to the full-fledged XP level. Dependent plurals, however, have the in-between status syntactically and combine with the X'-structure. Another difference is found between ordinary plurals and dependent plurals, on the one hand, and anti-quantifiers, on the other, in the respect that the former is a morpheme while the latter is a phrase that can take its own complement. These different statuses seem to account for why plural forms are intrinsically ambiguous whereas anti-quantifiers are unambiguously more expressive in their semantics as well as in their syntax than ordinary plurals and dependent plurals.
Yoon-kyoung Joh 서울대학교 언어교육원 2020 語學硏究 Vol.56 No.1
This paper claims that adorning materials in middles can commonly be translated into adverbials since modality, negation, and focus can all be expressed using various types of adverbials. Through the analytical lens that views middle constructions as distributivity constructions that are essentially reduced to plurality, this common property among adorning materials in middles is highly interesting. Thus, this paper accounts for the adorning materials in middles in Joh’s (2016) analysis, which treats adverbials in middles as one of distributivity’s core arguments. This paper also discusses how adverbials that are implicitly inserted in middle sentences can be conditioned. To answer this question, this paper relies on the differentiating effect that Sohn (2003) examined, extending the previously proposed unexpectedness condition.
Application of whole‐exome sequencing for detecting copy number variants in CMT1A/HNPP
Jo, H.‐,Y.,Park, M.‐,H.,Woo, H.‐,M.,Han, M.H.,Kim, B.‐,Y.,Choi, B.‐,O.,Chung, K.W.,Koo, S.K. Blackwell Publishing Ltd 2016 Clinical genetics Vol.90 No.2
<P>Large insertions and deletions (indels), including copy number variations (CNVs), are commonly seen in many diseases. Standard approaches for indel detection rely on well‐established methods such as qPCR or short tandem repeat (STR) markers. Recently, a number of tools for CNV detection based on next‐generation sequencing (NGS) data have also been developed; however, use of these methods is limited. Here, we used whole‐exome sequencing (WES) in patients previously diagnosed with CMT1A or HNPP using STR markers to evaluate the ability of WES to improve the clinical diagnosis. Patients were evaluated utilizing three CNV detection tools including CONIFER, ExomeCNV and CEQer, and array comparative genomic hybridization (aCGH). We identified a breakpoint region at 17p11.2‐p12 in patients with CMT1A and HNPP. CNV detection levels were similar in both 6 Gb (mean read depth = 80×) and 17 Gb (mean read depth = 190×) data. Taken together, these data suggest that 6 Gb WES data are sufficient to reveal the genetic causes of various diseases and can be used to estimate single mutations, indels, and CNVs simultaneously. Furthermore, our data strongly indicate that CNV detection by NGS is a rapid and cost‐effective method for clinical diagnosis of genetically heterogeneous disorders such as CMT neuropathy.</P>
Jo H.,Shin E.,Kim H. 서울시립대학교 도시과학연구원 2020 도시과학국제저널 Vol.24 No.4
Recently, as the number of cyclists has grown in Seoul, Korea, bicycle traffic accidents have also increased rapidly. Most precedent research concerning bicycle traffic accidents has focused on the cases where motor vehicles have injured cyclists. Unlike preceding studies, this study focuses on the cases where bicycles have collided with pedestrians. The purpose of this study is to identify the spatial characteristics of the bicycle-to-person collisions caused by bicycles. Binomial Logistic Model is used to identify the spatial relationships of bicycle-to-pedestrian collisions. For the analysis, the entire Han River Park is broken down into 50 × 50 m grids, which become the units of analysis of this study. The target period for the analysis is set from 2014 to 2016. Dependent variables are accident points in the Han River Park. As the independent variables, the variety of spatial and physical factors of the Han River Park are considered. The model shows that the crosswalks, speed restriction features, street furniture, floating population, and bicycle rental shops in the Han River Park are significant factors relating to bicycle-to-pedestrian collisions.
Single bubble dynamics on hydrophobic-hydrophilic mixed surfaces
Jo, H.,Park, H.S.,Kim, M.H. Pergamon Press ; Elsevier Science Ltd 2016 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.93 No.-
Single bubble dynamics of distilled water were experimentally investigated on hydrophobic-hydrophilic mixed surfaces with hydrophobic dot diameters ranging from 50μm to 6mm. The heterogeneity of surface wettability could affect interfacial dynamics and cause the pinning phenomenon of the bubble interface, a contact angle transition, a 'stick-slip' behavior, and the interface necking during bubble growth. The triple line of a bubble initiated from a hydrophobic dot was pinned at its edge where a singularity of the surface wettability occurs. During this contact line pinning, the contact angle of bubble interface decreased. When the contact angle decreased to equal the receding contact angle of a bare hydrophilic surface, the triple line moved outward rapidly; this is called 'slip' behavior. After such process, the nucleated bubble vertically elongated and subsequently departed from the surface. The contact angle transition during the pinning and departing behavior was described by considering the capillary length of the bubble determined by the vertical deformation of bubbles. Using the bubble dynamics on the heterogeneously patterned surface with compactly arranged 50μm dots, boiling heat transfer coefficient enhanced to 2.1 times that in the bare hydrophilic surface.
A highly sensitive and selective impedimetric aptasensor for interleukin-17 receptor A
Jo, H.,Kim, S.K.,Youn, H.,Lee, H.,Lee, K.,Jeong, J.,Mok, J.,Kim, S.H.,Park, H.S.,Ban, C. Elsevier Applied Science 2016 Biosensors & bioelectronics Vol.81 No.-
Interleukin-17 receptor A (IL-17RA) has been recognized as a valuable biomarker for diverse diseases, including autoimmune diseases. In this work, an electrochemical biosensor with great sensitivity and selectivity toward IL-17RA was fabricated using an IL-17RA aptamer (K<SUB>d</SUB>=14.00nM) for the first time. The aptasensor was manufactured using electrodeposition of gold nanoparticles, and then quantitative detection of IL-17RA was performed based on impedimetry. The developed sensor exhibited a superior analytical performance for IL-17RA with a wide dynamic range of 10-10,000pg/mL in buffer and a detection limit of 2.13pg/mL, which is lower than that of commercially available ELISA kits. In addition, we validated the high specificity of the designed aptasensor to only IL-17RA, which showed good sensitivity even in human serum solution. Furthermore, the detection of the differentiated HL-60 cells expressing IL-17RA was successfully performed. Clinical applicability of the sensor was also demonstrated utilizing neutrophils separated from asthma patients. It is expected that the fabricated aptasensor will become an excellent diagnostic platform for IL-17RA-mediated diseases.