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청갓과 적갓에 함유된 Glucosinolates의 항암 활성 및 정량 분석
김활 ( Hwal Kim ),김준열 ( Jun Yeol Kim ),김효진 ( Hyo Jin Kim ),김도경 ( Do Kyung Kim ),조혜진 ( Hye Jin Jo ),한병수 ( Byoung Su Han ),김헌웅 ( Heon Woong Kim ),김정봉 ( Jung Bong Kim ) 한국식품영양학회 2011 韓國食品營養學會誌 Vol.24 No.3
The objective of this study was to compare the anticancer activity of glucosinolates against four different cancer cells; SNU-251, SNU-354, SNU-C4, MCF-7 and to determine the amounts of glucosinolates in mustard leaves. Green and red mustard leaves were cultivated on the field of Rural Development Administration from May to July, 2010. After the leaves were harvest and lypophilized, the fine powder was extracted with boiling 70% methanol(v/v) for the measurement of anticancer activity and then applied to the cancer cells obtained from Korean Cell Line Bank(KCLB). The anticancer activity of red leaf mustard was higher than that of green mustard leaf, particularly in SNU-251 for 24 hr and in SNU-C4 for 48 hr. In both green and red mustard leaf, sinigrin was the most abundant glucosinolte and was determined as 4.71 and 3.06 ㎎/g dry wt., respectively, but glucoiberin only presented 0.14 ㎎/g dry wt. with minor amounts.
Microbial Contamination Levels of Strawberries at Domestic Farms of South Korea
Kim, Won-Il,Jo, A-Ra,Kim, Se-Ri,Ryu, Song Hee,Nam, Ki-Woong,Yoon, Yohan,Yoon, Deok-Hoon,Oh, So-Yong,Nam, Myeong Hyeon,Ryu, Jae-Gee,Kim, Hwang-Yong 한국토양비료학회 2014 한국토양비료학회지 Vol.47 No.6
Foodborne illness due to the consumption of contaminated raw strawberries is a continuing food safety concern. This study investigated and evaluated contamination levels of bacteria on strawberries at farms stage to evaluate potential hazards associated with fresh strawberries. A total of 315 samples, 105 samples from 5 sampling sites (A to E) of 21 farms and 210 samples from 1 sampling site of 6 farms, was collected every month for four months and analyzed to enumerate aerobic bacterial counts, Coliforms/E. coli, Bacillus cereus and Staphylococcus aureus. In addition, the prevalence study of five pathogens (S. aureus, E. coli, E. coli O157:H7, Salmonella spp. and Listeria monocytogenes) was performed on each sample. Aerobic bacterial counts ranged from 0.48 to 6.36 Log CFU/g, with the highest bacterial cell counts recorded for D and E sites. Coliforms were detected in 71 samples (22.5%) with a minimum of 0.48 cfu/g and a maximum of more than 4 Log CFU/g. B. cereus was detected in 98 samples (31.1%) among total samples analyzed. S. aureus was detected in 2 samples with a minimum of 0.48 Log CFU/g and a maximum of 1.38 Log CFU/g. E. coli, E. coli O157:H7, Salmonella spp. and L. monocytogenes were not isolated from any of the samples. The microbial contamination levels of strawberries determined in this study may be used as the fundamental data for microbiological risk assessment.
Kim, Hyun-A.,Lee, Byung-Tae,Na, So-Young,Kim, Kyoung-Woong,Ranville, James F.,Kim, Soon-Oh,Jo, Eunhye,Eom, Ig-Chun Elsevier 2017 CHEMOSPHERE - Vol.171 No.-
<P><B>Abstract</B></P> <P>The single particle-inductively coupled plasma-mass spectrometry was applied to characterize the aggregates of AgNPs. was applied to characterize the aggregates of AgNPs. Two sizes of citrate-AgNPs and PVP-AgNPs were used at relatively high and predicted environmental concentrations under various ionic strengths. Citrate-AgNP aggregated with increases in the ionic strength, whereas PVP-AgNPs were sterically stable. The critical coagulation concentrations were 85 mM and 100 mM NaNO<SUB>3</SUB> for 60 nm and 100 nm citrate-AgNPs at 2 mg L<SUP>−1</SUP> as total Ag obtained by dynamic light scattering (DLS). At 2 mg L<SUP>−1</SUP> as total Ag, the mass of an aggregate gradually increased with increasing ionic strength for both citrate-AgNP during spICP-MS analyses. The average number of single particles derived from the mass in an aggregate was calculated to be 8.68 and 5.95 for 60 nm and 100 nm citrate-AgNPs at 85 mM and 100 mM NaNO<SUB>3</SUB>, respectively after 2 h. The mass fractal dimensions were determined to be 2.97 and 2.83, further implying that the aggregate structures were very rigid and compact. Only marginal increases in the average mass and number of single particles in the aggregate units were found during 24 h under environmentally relevant AgNP concentrations. The average number of single particles constituting an aggregate unit for 60 nm and 100 nm citrate-AgNPs was 1.24 and 1.37 after 24 h at a high ionic strength. These results indicate that under environmentally relevant conditions, the collision frequency is predominant in the aggregation and that NPs are likely to encounter natural colloids such as clay and organic matter to form hetero-aggregates.</P> <P><B>Highlights</B></P> <P> <UL> <LI> spICP-MS was recommended for characterization of silver nanoparticle aggregates. </LI> <LI> The gradually increase of mass in an aggregate was observed in spICP-MS analysis. </LI> <LI> The number of single particles in an aggregate was calculated based on the mass. </LI> <LI> The aggregates structures are characterized by mass fractal dimension. </LI> </UL> </P>
Dynamic characteristics of steam generator U-tubes with defect
Jo, Jong Chull,Jhung, Myung Jo,Kim, Woong Sik,Kim, Hho Jung Elsevier 2005 Nuclear engineering and design Vol.235 No.7
<P><B>Abstract</B></P><P>This study investigates the fluid elastic instability characteristics of steam generator (SG) U-tubes with defect and the safety assessment of the potential for fretting-wear damages caused by foreign object in operating nuclear power plants. To get the natural frequency, corresponding mode shape and participation factor, modal analyses are performed for the U-tubes either with axial or circumferential flaw with different sizes. Special emphases are on the effects of flaw orientation and size on the modal and instability characteristics of tubes, which are expressed in terms of the natural frequency, corresponding mode shape and stability ratio. Also, the wear rate of U-tube caused by foreign object is calculated using the Archard formula and the remaining life of the tube is predicted, and discussed in this study is the effect of the flow velocity and vibration of the tube on the remaining life of the tube. In addition, addressed in this study is the effect of the internal pressure on the vibration and fretting-wear characteristics of the tube.</P>
Jo, Dong Hyun,Kim, Jin Hyoung,Park, Woong-Yang,Kim, Kyu-Won,Yu, Young Suk,Kim, Jeong Hun Lippincott Williams Wilkins, Inc. 2011 Journal of pediatric hematology/oncology Vol.33 No.7
Retinoblastoma (RB) is the most common intraocular malignant tumor in childhood. To investigate differential expression of microRNAs (miRNAs) in RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth, miRNA microarray was performed. Common mRNA targets of each miRNA were extracted from 4 web-based databases: TargetScan, miRanda, RNAhybrid, and PicTar. Biological functions of target genes were predicted with the PANTHER Classification System. We identified 39 differentially expressed miRNAs between 2 cell lines: 22 were upregulated in SNUOT-Rb1 cells, and the other 17 were overexpressed in Y79 cells. More than half of top 10 mRNA targets of hsa-miR-10b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, and hsa-let-7c in SNUOT-Rb1 cells and hsa-miR-34a, hsa-miR-34c-5p, hsa-miR-124, hsa-miR-135b, hsa-miR-142-5p, and hsa-let-7i in Y79 cells were related with biological processes, which could affect the growth patterns of cells: cell adhesion, cell cycle, cell death, and cell division. On the basis of the data from the target analysis of each miRNA, we found out several miRNAs, which were differentially expressed and had targets of possible impact on progression of RB. From these analyses, we suggest that some differential miRNAs could have roles in miRNA-targeted treatments on RB.
Fretting-Wear Characteristics of Steam Generator Tubes by Foreign Object
Jo Jong Chull,Jhung Myung Jo,Kim Woong Sik,Choi Young Hwan,Kim Hho Jung,Kim Tae Hyung Korean Nuclear Society 2003 Nuclear Engineering and Technology Vol.35 No.5
This study investigates the safety assessment of the potential for fretting-wear damages on steam generator (SG) U-tubes caused by foreign object in operating nuclear power plants. The operating SG shell-side flow field conditions are obtained from three-dimensional SG flow calculation using the ATHOS3 code. Modal analyses are performed for the finite element modelings of U-tubes to get the natural frequency, corresponding mode shape and participation factor. The wear rate of U-tube caused by foreign object is calculated using the Archard formula and the remaining life of the tube is predicted. Also, discussed in this study is the effect of the flow velocity and vibration of the tube on the remaining life of the tube.
Kim, Han Young,Kumar, Hemant,Jo, Min-Jae,Kim, Jonghoon,Yoon, Jeong-Kee,Lee, Ju-Ro,Kang, Mikyung,Choo, Yeon Woong,Song, Seuk Young,Kwon, Sung Pil,Hyeon, Taeghwan,Han, In-Bo,Kim, Byung-Soo American Chemical Society 2018 NANO LETTERS Vol.18 No.8
<P>Human mesenchymal stem cell (hMSC)-derived exosomes have been spotlighted as a promising therapeutic agent for cell-free regenerative medicine. However, poor organ-targeting ability and insufficient therapeutic efficacy of systemically injected hMSC-exosomes were identified as critical limitations for their further applications. Therefore, in this study we fabricated iron oxide nanoparticle (IONP)-incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP-treated hMSCs and evaluated their therapeutic efficacy in a clinically relevant model for spinal cord injury. Compared to exosome-mimetic nanovesicles (NV) prepared from untreated hMSCs, NV-IONP not only contained IONPs which act as a magnet-guided navigation tool but also carried greater amounts of therapeutic growth factors that can be delivered to the target cells. The increased amounts of therapeutic growth factors inside NV-IONP were attributed to IONPs that are slowly ionized to iron ions which activate the JNK and c-Jun signaling cascades in hMSCs. In vivo systemic injection of NV-IONP with magnetic guidance significantly increased the amount of NV-IONP accumulating in the injured spinal cord. Accumulated NV-IONP enhanced blood vessel formation, attenuated inflammation and apoptosis in the injured spinal cord, and consequently improved spinal cord function. Taken together, these findings highlight the development of therapeutic efficacy-potentiated extracellular nanovesicles and demonstrate their feasibility for repairing injured spinal cord.</P> [FIG OMISSION]</BR>