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Analysis of structure and P-c-T curve of hydrogenated Ti53Zr27xNi20Pd(x) quasicrystals.
Jo, Youngsoo,Lee, Sang-Hwa,Shin, Hong Sik,Kim, Jaeyong American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.12
<P>The potential application of TiZrNi quasicrystals was evaluated by measuring the pressure-composition-temperature curves after replacing Zr by Pd to the limit maintaining the host structure for the samples made with Ti53Zr27(-x)Ni20Pd(x), where 0 < or = x < or = 8. The results of X-ray diffraction data revealed that the samples keep the pure quasicrystal structure to the maximum value of x = 8. All diffracted peaks uniformly shifted to the low angle of 2 theta in X-ray diffraction pattern suggesting that hydrogen atoms homogeneously diffuse in the quasicrystals and uniformly expand the quasilattice constants without modification of the structure. After hydrogenation at elevated temperature, the quasi-lattice constants increased from 5.12 to 5.34 angstroms for the samples made with x = 0 without appearing an impurity phase. When Zr was replaced by 8 at.% of Pd, the equilibrium vapor pressures significantly increased to 3.41 from 0.41 Torr at 300 degrees C although the total amount of hydrogen decreased as increasing Pd concentration. These results demonstrate that Pd will play a critical role in application for the TiZrNi quasicrystals as hydrogen storage materials.</P>
Jo, Hyeju,Zhou, Yuanyuan,Viji, Mayavan,Choi, Minho,Lim, Jae Young,Sim, Jaeuk,Rhee, Jeongtae,Kim, Youngsoo,Seo, Seung-Yong,Kim, Wun-Jae,Hong, Jin Tae,Lee, Heesoon,Lee, Kiho,Jung, Jae-Kyung Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.21
<P><B>Abstract</B></P> <P>A series of catechol and dioxolane analogs containing thiazole CGA derivatives have been synthesized and evaluated for their inhibitory activity against α-MSH. The inhibitory activity was improved by replacing an α,β-unsaturated carbonyl of previously reported caffeamides with thiazole motif. Surprisingly, compound <B>7d</B>, one of the derivatives of dioxolane analogs, displayed the most potent inhibitory activity with an IC<SUB>50</SUB> of 0.90μM. Further studies on metabolic stability and bioactivation potential were also accomplished.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jo, Hyeju,Choi, Minho,Sim, Jaeuk,Viji, Mayavan,Li, Siyuan,Lee, Young Hee,Kim, Youngsoo,Seo, Seung-Yong,Zhou, Yuanyuan,Lee, Kiho,Kim, Wun-Jae,Hong, Jin Tae,Lee, Heesoon,Jung, Jae-Kyung Pergamon Press 2017 Bioorganic & medicinal chemistry letters Vol.27 No.15
<P><B>Abstract</B></P> <P>We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
분리막 공정과 LNG 냉열 및 심냉 증류를 이용한 전자급 고순도 이산화탄소의 분리
고영수(YOUNGSOO KO),장경룡(KYUNGRYONG JANG),김정훈(JUNGHOON KIM),조영주(YOUNGJOO JO),조정호(JUNGHO CHO) 한국수소및신에너지학회 2024 한국수소 및 신에너지학회논문집 Vol.35 No.1
In this paper, a new technology to obtain electronic grade, highly pure carbon dioxide by using membrane and liquefied natural gas (LNG) cold heat assisted cryogenic distillation has been proposed. PRO/II with PROVISION release 2023.1 from AVEVA company was used, and Peng-Robinson equation of the state model with Twu’s alpha function to predict pure component vapor pressure versus temperature more accurately was selected for the modeling of the membrane and cryogenic distillation process. Advantage of using membrane separation instead of selecting absorber-stripper configuration for the concentration of carbon dioxide was the reduction of carbon dioxide capture cost.
Single‐Gate Bandgap Opening of Bilayer Graphene by Dual Molecular Doping
Park, Jaesung,Jo, Sae Byeok,Yu, Young‐,Jun,Kim, Youngsoo,Yang, Jae Won,Lee, Wi Hyoung,Kim, Hyun Ho,Hong, Byung Hee,Kim, Philip,Cho, Kilwon,Kim, Kwang S. WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.3
<P><B>Dual doping‐driven perpendicular electric field with opposite directions</B> remarkably increase the on/off current ratio of bilayer graphene field‐effect transistors. This unambiguously proves that it is possible to open a bandgap with two molecular dopants (F4‐TCNQ and NH<SUB>2</SUB>‐functionalized self‐assembled monolayers (SAMs)) even in a single‐gate device structure.</P>
Lee, Sangkyu,Jo, Insu,Kang, Sangmin,Jang, Bongchul,Moon, Joonhee,Park, Jong Bo,Lee, Soochang,Rho, Sichul,Kim, Youngsoo,Hong, Byung Hee American Chemical Society 2017 ACS NANO Vol.11 No.6
<P>Recently, smart contact lenses with electronic circuits have been proposed for various sensor and display applications where the use of flexible and biologically stable electrode materials is essential. Graphene is an atomically thin carbon material with a two-dimensional hexagonal lattice that shows outstanding electrical and mechanical properties as well as excellent biocompatibility. In addition, graphene is capable of protecting eyes from electromagnectic (EM) waves that may cause eye diseases such as cataracts. Here, we report a graphene-based highly conducting contact lens platform that reduces the exposure to EM waves and dehydration. The sheet resistance of the graphene on the contact lens is as low as 593 Omega/sq (+/- 9.3%), which persists in an wet environment. The EM wave shielding function of the graphene-coated contact lens was tested on egg whites exposed to strong EM waves inside a microwave oven. The results show that the EM energy is absorbed by graphene and dissipated in the form of thermal radiation so that the damage on the egg whites can be minimized. We also demonstrated the enhanced dehydration protection effect of the graphene-coated lens by monitoring the change in water evaporation rate from the vial capped with the contact lens. Thus, we believe that the graphene-coated contact lens would provide a healthcare and bionic platform for wearable technologies in the future.</P>
<i>TrpA1</i> Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway
Du, Eun Jo,Ahn, Tae Jung,Kwon, Ilmin,Lee, Ji Hye,Park, Jeong-Ho,Park, Sun Hwa,Kang, Tong Mook,Cho, Hana,Kim, Tae Jin,Kim, Hyung-Wook,Jun, Youngsoo,Lee, Hee Jae,Lee, Young Sik,Kwon, Jae Young,Kang, Kye Public Library of Science 2016 PLoS genetics Vol.12 No.1
<▼1><P>Pathogen expulsion from the gut is an important defense strategy against infection, but little is known about how interaction between the intestinal microbiome and host immunity modulates defecation. In <I>Drosophila melanogaster</I>, dual oxidase (Duox) kills pathogenic microbes by generating the microbicidal reactive oxygen species (ROS), hypochlorous acid (HOCl) in response to bacterially excreted uracil. The physiological function of enzymatically generated HOCl in the gut is, however, unknown aside from its anti-microbial activity. <I>Drosophila</I> TRPA1 is an evolutionarily conserved receptor for reactive chemicals like HOCl, but a role for this molecule in mediating responses to gut microbial content has not been described. Here we identify a molecular mechanism through which bacteria-produced uracil facilitates pathogen-clearing defecation. Ingestion of uracil increases defecation frequency, requiring the <I>Duox</I> pathway and <I>TrpA1</I>. The <I>TrpA1(A)</I> transcript spliced with exon10b (<I>TrpA1(A)10b</I>) that is present in a subset of midgut enteroendocrine cells (EECs) is critical for uracil-dependent defecation. TRPA1(A)10b heterologously expressed in <I>Xenopus</I> oocytes is an excellent HOCl receptor characterized with elevated sensitivity and fast activation kinetics of macroscopic HOCl-evoked currents compared to those of the alternative TRPA1(A)10a isoform. Consistent with <I>TrpA1</I>’s role in defecation, uracil-excreting <I>Erwinia carotovora</I> showed higher persistence in <I>TrpA1-</I>deficient guts. Taken together, our results propose that the uracil/Duox pathway promotes bacteria expulsion from the gut through the HOCl-sensitive receptor, TRPA1(A)10b, thereby minimizing the chances that bacteria adapt to survive host defense systems.</P></▼1><▼2><P><B>Author Summary</B></P><P>The amount and pattern of defecation are often determined by the bacterial composition in the gut, and can have a significant impact on human health. It is however unknown how changes in the bacterial community affect defecation. A chemical defense system called the <I>Duox</I> pathway is known to kill ill-causing bacteria in the gut by producing chlorine bleach. Our study reveals that the bleach does not stop there, working further to promote expulsion of the bacteria from the gut through a sensitive bleach detector. Moreover, in the gut deficient for the bleach detector, the bacteria not only stayed longer, but also opportunistically survived the bleach that they encounter afterwards. This is the first identification of a mechanism illustrating how important it is that gut defense systems control defecation, and helps explain why troubles in the gut cause changes in defecation.</P></▼2>
Song, Da Hye,Jo, Yang Hee,Ahn, Jong Hoon,Kim, Seon Beom,Yun, Cheong-Yong,Kim, Youngsoo,Hwang, Bang Yeon,Lee, Mi Kyeong Springer-Verlag 2018 Journal of natural medicines Vol.72 No.1
<P>Melanin, a dark macromolecular pigment, protects skin from harmful damage. However, abnormal accumulation is responsible for hyperpigmentation disorders. Melanogenesis inhibitors have therefore become important constituents in cosmetic products for depigmentation. Torilis japonica Decandolle (Umbelliferae) is a biennial plant which is distributed in East Asia. Fruits of this plant have been used for the treatment of skin disease and inflammation. In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in alpha-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. Further extensive chromatographic separation resulted in thirteen compounds. On the basis of spectroscopic analysis, the structures of the compounds isolated were determined to be three new sesquiterpenes, viz. a guaiane-type, epoxytorilinol (1), a eudesmane-type, elematorilone (2) and a cadinane-type, cardinatoriloside (3), together with ten known sesquiterpenes (4-13). Of the compounds isolated, compounds 4-6 and 11-13 inhibited alpha-MSH-activated melanin production in B16 melanoma cells with IC50 values from 72.9 to 191.0 mu M.</P>