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빅벨리해마(Hippocampus abdominalis)에서의 Mitochondrial Heat Shock Protein 75 유전자의 특징과 발현 분석
고지연 ( Jiyeon Ko ),( Wan Qiang ),이숙경 ( Sukkyoung Lee ),( S. D. N. K. Bathige ),오민영 ( Minyoung Oh ),이제희 ( Jehee Lee ) 한국수산과학회 2015 한국수산과학회지 Vol.48 No.3
Mitochondrial heat shock protein 75 (mtHSP75) is a member of the HSP90 family and plays essential roles in re-folding proteins of the mitochondrial matrix. Mitochondria provide energy in the form of ATP and generate reactive oxygen species (ROS). Heat shock proteins (HSPs) are activated in response to stress, and protect cells. In this study, we characterized the mtHSP75 of the big-belly seahorse Hippocampus abdominalis. The protein (BsmtHSP75) is encoded by an open reading frame (ORF) of 2,157 nucleotides, has 719 amino acids (aa), and is of molecular mass 82 kDa. BsmtHSP75 has two functional domains, a histidine kinase-like ATPase (HATPase_c) domain (123-276 aa) and an HSP90 family domain (302-718 aa). BsmtHSP75 was expressed in all tested tissues of healthy seahorses. The ovary contained the highest transcription level, followed (in order) by the blood, brain, and muscle. Pouch tissue showed the lowest expression level. The expression of BsmtHSP75 was significantly (P<0.05) up-regulated on viral or bacterial challenge, suggesting that BsmtHSP75 plays a role in the immune defense against bacterial and viral pathogens.
( Yousang Ko ),( Hyung Woo Kim ),( Jinsoo Min ),( Jee Youn Oh ),( Ji Young Kang ),( Hyeon-kyoung Koo ),( Yunhyung Kwon ),( Jiyeon Yang ),( Jiyeon Han ),( You Jin Jang ),( Sung-soon Lee ),( Jae Seuk Pa 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Early diagnosis and subsequent treatment for pulmonary tuberculosis (PTB) is essential for Tuberculosis prevention and control. Despite South Korea is an area of intermediate TB burden with a prevalence rate of 101/100,000 persons in 2014, there has been no investigation for determining factors associated with delays. It is necessary to guide public health action. Methods A nationwide, prospective, and observational cohort study for tuberculosis patients has been ongoing in Korea since September 2018. We described the distribution of delays from symptom onset to first visit of medical facility (patient-related delay) and from presentation to treatment (healthcare-related delay). Factors associated with patient-related delay and healthcare-related delay was identified using a multivariable analysis model. Results A total of 6,715 patients were diagnosed with PTB in 2019. For patient-related delay and healthcare-related delay were included as 3,783 and 5,660 cases, respectively. Mean patient-related delay was 49.4 (± 110.8). In multivariate regression analysis, Neuro-psychiatric disease was an independent risk factor for patient-related delay (HR 1.444; 95% confidence interval 1.191 to 1.750, p<0.001), malignancy (HR 1.313; 95% confidence interval 1.172 to 1.471, p<0.001), extra-PTB (HR 1.283; 95% confidence interval 1.150 to 1.431, p<0.001) and poor economic status (HR 1.090; 95% confidence interval 1.005 to 1.182, p=0.037). Mean healthcare-related delay was 13.3 (± 34.9). In multivariate regression analysis, Age over 65 years was an independent risk factor for healthcare-related delay (HR 1.120; 95% confidence interval 1.048 to 1.198, p=0.001) and early PTB defined as low microbiologic burden (HR 1.313; 95% confidence interval 1.206 to 1.429, p<0.001). Conclusions Our findings support continued initiatives to enable access to care for patients with neuro-psychiatric disease, malignancy, extra-PTB and poor economic status to reduce patient-related delayiagnosis of PTB. Moreover, clinician should pay attention in elderly and have awareness of TB clinical characteristics to find early PTB case.
Jiyeon Kim,Yeon Kyung Lee,Sun Young Ko,Son Moon Shin 대한신생아학회 2019 Neonatal medicine Vol.26 No.2
Purpose: To investigate clinical markers for the diagnosis of congenital cytomegalovirus (CMV) infection and determine the correlation between abnormal newborn hearing screening results and asymptomatic congenital CMV infection. Methods: Medical records of newborns with congenital CMV infection, born at Cheil General Hospital & Women's Healthcare Center from July 2008 to June 2018, were retrospectively reviewed. Infants with congenital CMV infection were classified into “symptomatic,” “asymptomatic,” and “asymptomatic with isolated abnormal automated auditory brainstem response (AABR)” groups. Clinical data were analyzed based on this classification. Results: Among the 59,424 live births, congenital CMV infection was found in 25 neonates, including 19 symptomatic (0.03%) infants, two asymptomatic, and four asymptomatic with isolated abnormal AABR. Diagnostic clues for the identification of congenital CMV infection were intrauterine growth restriction (IUGR), including microcephaly in 10 infants (40.0%), abnormal AABR in four (16.0%), initial complicated signs in four (16.0%), and abnormal findings on brain ultrasonography in three (12.0%). Other less common markers included petechiae, abnormal findings on antenatal ultrasonography, and co-twin with CMV infection. During the recent 10 years, 53,094 of 59,424 newborns (89.3%) had AABR for hearing screening and 493 (0.9%) did not pass. Among them, 477 (96.8%) were screened for CMV, and results were positive for seven (1.5%). Among the seven infants, four had asymptomatic congenital CMV infection. Overall, 0.8% of the newborns with abnormal AABR (four of 477 infants) were diagnosed as having asymptomatic congenital CMV infection. Conclusion: The incidence of symptomatic congenital CMV infection was 0.03%, and 0.8% of infants who failed in the newborn hearing screening tests had asymptomatic congenital CMV infection. The most common clinical marker to diagnose congenital CMV infection was IUGR, including microcephaly, and the second isolated marker was abnormal AABR.
Ko, Kuk Won,Lee, Jiyeon,Moon, Hongsuk,Lee, Sangjoon The Institute of Internet 2015 International Journal of Internet, Broadcasting an Vol.7 No.2
Biometric techniques for authentication using body parts such as a fingerprint, face, iris, voice, finger-vein and also photoplethysmography have become increasingly important in the personal security field, including door access control, finance security, electronic passport, and mobile device. Finger-vein images are now used to human identification, however, difficulties in recognizing finger-vein images are caused by capturing under various conditions, such as different temperatures and illumination, and noise in the acquisition camera. The human photoplethysmography is also important signal for human identification. In this paper To increase the recognition rate, we develop camera based identification method by combining finger vein image and photoplethysmography signal. We use a compact CMOS camera with a penetrating infrared LED light source to acquire images of finger vein and photoplethysmography signal. In addition, we suggest a simple pattern matching method to reduce the calculation time for embedded environments. The experimental results show that our simple system has good results in terms of speed and accuracy for personal identification compared to the result of only finger vein images.