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( Yousang Ko ),( Wooyoul Kim ),( Beom Su Shin ),( Hongseok Yoo ),( Jung Seop Eom ),( Ji Hyun Lee ),( Byung Woo Jhun ),( Su Young Kim ),( Go Eun Choi ),( Sung Jae Shin ),( Won Jung Koh ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.74 No.4
Mycobacterium chelonae lung disease is very rare. We report a case of lung disease caused by M. chelonae in a previously healthy woman. A 69-year-old woman was referred to our hospital because of hemoptysis. A computed tomography (CT) scan of the chest revealed bronchiolitis associated with bronchiectasis in the lingular division of the left upper lobe. Nontuberculous mycobacteria were isolated three times from sputum specimens. All isolates were identified as M. chelonae by various molecular methods that characterized rpoB and hsp65 gene sequences. Although some new lesions including bronchiolitis in the superior segment of the left lower lobe developed on the chest CT scan 35 months after diagnosis, she has been followed up without antibiotic therapy because of her mild symptoms. To the best of our knowledge, this is the first case of M. chelonae lung disease in Korea in which the etiologic organisms were confirmed using molecular techniques.
Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium chelonae: A Case Report
Ko, Yousang,Kim, Wooyoul,Shin, Beom Su,Yoo, Hongseok,Eom, Jung Seop,Lee, Ji Hyun,Jhun, Byung Woo,Kim, Su-Young,Choi, Go-Eun,Shin, Sung Jae,Koh, Won-Jung The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.74 No.4
Mycobacterium chelonae lung disease is very rare. We report a case of lung disease caused by M. chelonae in a previously healthy woman. A 69-year-old woman was referred to our hospital because of hemoptysis. A computed tomography (CT) scan of the chest revealed bronchiolitis associated with bronchiectasis in the lingular division of the left upper lobe. Nontuberculous mycobacteria were isolated three times from sputum specimens. All isolates were identified as M. chelonae by various molecular methods that characterized rpoB and hsp65 gene sequences. Although some new lesions including bronchiolitis in the superior segment of the left lower lobe developed on the chest CT scan 35 months after diagnosis, she has been followed up without antibiotic therapy because of her mild symptoms. To the best of our knowledge, this is the first case of M. chelonae lung disease in Korea in which the etiologic organisms were confirmed using molecular techniques.
Ko, Yousang,Shin, Jeong Hwan,Lee, Hyun-Kyung,Lee, Young Seok,Lee, Suh-Young,Park, So Young,Mo, Eun-Kyung,Kim, Changhwan,Park, Yong Bum The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1
Background: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non-drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. Methods: We evaluated the duration of infectiousness of PTB using a retrospective cohort design. Results: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0-42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5-28.0 days). Conclusion: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB.
( Yousang Ko ),( Jeong Hwan Shin ),( Hyun-kyung Lee ),( Young Seok Lee ),( Suh-young Lee ),( So Young Park ),( Eun-kyung Mo ),( Changhwan Kim ),( Yong Bum Park ) 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1
Background: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study was to evaluate the infectious period in patients with non-drug-resistant (DR) PTB receiving adequate standard chemotherapy, using induced sputum (IS) specimens. Methods: We evaluated the duration of infectiousness of PTB using a retrospective cohort design. Results: Among the 35 patients with PTB, 22 were smear-positive. The rates of IS culture positivity from baseline to the sixth week of anti-tuberculosis medication in the smear-positive PTB group were 100%, 100%, 91%, 73%, 36%, and 18%, respectively. For smear-positive PTB cases, the median time of conversion to culture negativity was 35.0 days (range, 28.0-42.0 days). In the smear-negative PTB group (n=13), the weekly rates of positive IS culture were 100%, 77%, 39%, 8%, 0%, and 0%, respectively, and the median time to conversion to culture-negative was 21.0 days (range, 17.5-28.0 days). Conclusion: The infectiousness of PTB, under adequate therapy, may persist longer than previously reported, even in patients with non-DR PTB.
( Yousang Ko ),( Hyung Woo Kim ),( Jinsoo Min ),( Jee Youn Oh ),( Ji Young Kang ),( Hyeon-kyoung Koo ),( Yunhyung Kwon ),( Jiyeon Yang ),( Jiyeon Han ),( You Jin Jang ),( Sung-soon Lee ),( Jae Seuk Pa 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Early diagnosis and subsequent treatment for pulmonary tuberculosis (PTB) is essential for Tuberculosis prevention and control. Despite South Korea is an area of intermediate TB burden with a prevalence rate of 101/100,000 persons in 2014, there has been no investigation for determining factors associated with delays. It is necessary to guide public health action. Methods A nationwide, prospective, and observational cohort study for tuberculosis patients has been ongoing in Korea since September 2018. We described the distribution of delays from symptom onset to first visit of medical facility (patient-related delay) and from presentation to treatment (healthcare-related delay). Factors associated with patient-related delay and healthcare-related delay was identified using a multivariable analysis model. Results A total of 6,715 patients were diagnosed with PTB in 2019. For patient-related delay and healthcare-related delay were included as 3,783 and 5,660 cases, respectively. Mean patient-related delay was 49.4 (± 110.8). In multivariate regression analysis, Neuro-psychiatric disease was an independent risk factor for patient-related delay (HR 1.444; 95% confidence interval 1.191 to 1.750, p<0.001), malignancy (HR 1.313; 95% confidence interval 1.172 to 1.471, p<0.001), extra-PTB (HR 1.283; 95% confidence interval 1.150 to 1.431, p<0.001) and poor economic status (HR 1.090; 95% confidence interval 1.005 to 1.182, p=0.037). Mean healthcare-related delay was 13.3 (± 34.9). In multivariate regression analysis, Age over 65 years was an independent risk factor for healthcare-related delay (HR 1.120; 95% confidence interval 1.048 to 1.198, p=0.001) and early PTB defined as low microbiologic burden (HR 1.313; 95% confidence interval 1.206 to 1.429, p<0.001). Conclusions Our findings support continued initiatives to enable access to care for patients with neuro-psychiatric disease, malignancy, extra-PTB and poor economic status to reduce patient-related delayiagnosis of PTB. Moreover, clinician should pay attention in elderly and have awareness of TB clinical characteristics to find early PTB case.
Ko, Yousang,Lee, Ho Young,Lee, Young Seok,Song, Junwhi,Kim, Mi-Yeong,Lee, Hyun-Kyung,Shin, Jeong Hwan,Choi, Seok Jin,Lee, Young-Min The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5
Miliary tuberculosis (TB) is a rare extrapulmonary form of TB, and there have been only two reports of miliary TB associated with infection with multidrug-resistant (MDR)-TB pathogen in an immunocompetent host. A 32-year-old woman was referred to our hospital because of abnormal findings on chest X-ray. The patient was diagnosed with MDR-TB by a line probe assay and was administered proper antituberculous drugs. After eight weeks, a solid-media drug sensitivity test revealed that the pathogen was resistant to ethambutol and streptomycin in addition to isoniazid and rifampicin. The patient was then treated with effective antituberculous drugs without delay after diagnosis of MDR-TB. To the best of our knowledge, this is the first case of miliary TB caused by MDR-TB pathogen in Korea.
Yousang Ko,Ho Young Lee,Young Seok Lee,Junwhi Song,Mi Yeong Kim,Hyun Kyung Lee,Jeong Hwan Shin,Seok Jin Choi,Young Min Lee 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5
Miliary tuberculosis (TB) is a rare extrapulmonary form of TB, and there have been only two reports of miliary TB associated with infection with multidrug-resistant (MDR)-TB pathogen in an immunocompetent host. A 32-year-old woman was referred to our hospital because of abnormal findings on chest X-ray. The patient was diagnosed with MDR-TB by a line probe assay and was administered proper antituberculous drugs. After eight weeks, a solid-media drug sensitivity test revealed that the pathogen was resistant to ethambutol and streptomycin in addition to isoniazid and rifampicin. The patient was then treated with effective antituberculous drugs without delay after diagnosis of MDR-TB. To the best of our knowledge, this is the first case of miliary TB caused by MDR-TB pathogen in Korea.
( Yousang Ko ),( Changhwan Kim ),( Boksoon Chang ),( Suh-young Lee ),( So Young Park ),( Eun-kyung Mo ),( Su Jin Hong ),( Myung Goo Lee ),( In Gyu Hyun ),( Yong Bum Park ) 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1
Background: Isolation of M. tuberculosis (MTB) is required in cases of Tuberculous pleural effusion (TBPE) for confirming diagnosis and successful therapy based on drug sensitivity test. Several studies have focused on predictors of MTB culture positivity in TBPE. However, the clinical role of loculated TBPE as a predictor of MTB cultivation from TBPE remains unclear. The aim of this study was to examine possible predictors including loculation of TBPE of MTB culture positivity in TBPE. Methods: We retrospectively examined associations between clinical, radiological, microbiological, and laboratory characteristics and positive MTB culture from TBPE to determine a potent predictor of culture positivity. Results: From January 2011 to August 2015, 232 patients with TBPE were identified. Of these, 219 were finally analyzed. Among them, 69 (31.5%) were culture positive for MTB in TBPE and 86 (39.3%) had loculated TBPE. In multivariate logistic regression analysis, the loculation of TBPE was independently associated with culture positivity for MTB in TBPE (adjusted odds ratio [OR], 40.062; 95% confidence interval [CI], 9.355-171.556; p<0.001). In contrast, the lymphocyte percentage of TBPE (adjusted OR, 0.934; 95% CI, 0.899-0.971; p=0.001) was inversely associated with culture positivity for MTB in TBPE. Conclusion: In clinical practice, identification of loculation in TBPE is easy, reliable to measure, not uncommon and may be helpful to predict the possibility of positive mycobacterial culture.
Ko, Yousang,Kim, Changhwan,Chang, Boksoon,Lee, Suh-Young,Park, So Young,Mo, Eun-Kyung,Hong, Su Jin,Lee, Myung Goo,Hyun, In Gyu,Park, Yong Bum The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1
Background: Isolation of M. tuberculosis (MTB) is required in cases of Tuberculous pleural effusion (TBPE) for confirming diagnosis and successful therapy based on drug sensitivity test. Several studies have focused on predictors of MTB culture positivity in TBPE. However, the clinical role of loculated TBPE as a predictor of MTB cultivation from TBPE remains unclear. The aim of this study was to examine possible predictors including loculation of TBPE of MTB culture positivity in TBPE. Methods: We retrospectively examined associations between clinical, radiological, microbiological, and laboratory characteristics and positive MTB culture from TBPE to determine a potent predictor of culture positivity. Results: From January 2011 to August 2015, 232 patients with TBPE were identified. Of these, 219 were finally analyzed. Among them, 69 (31.5%) were culture positive for MTB in TBPE and 86 (39.3%) had loculated TBPE. In multivariate logistic regression analysis, the loculation of TBPE was independently associated with culture positivity for MTB in TBPE (adjusted odds ratio [OR], 40.062; 95% confidence interval [CI], 9.355-171.556; p<0.001). In contrast, the lymphocyte percentage of TBPE (adjusted OR, 0.934; 95% CI, 0.899-0.971; p=0.001) was inversely associated with culture positivity for MTB in TBPE. Conclusion: In clinical practice, identification of loculation in TBPE is easy, reliable to measure, not uncommon and may be helpful to predict the possibility of positive mycobacterial culture.
오유상(Yousang Oh),이충기(Chunggi Lee),오주영(Juyoung Oh),양지현(Jihyeon Yang),곽희나(Heena Kwag),문성우(Seongwoo Moon),박소환(Sohwan Park),고성안(Sungahn Ko) 한국컴퓨터그래픽스학회 2016 컴퓨터그래픽스학회논문지 Vol.22 No.5
컴퓨터 그래픽스 (Computer Graphics) 및 인간-컴퓨터 상호작용 (Human-Computer Interaction, HCI) 기술을 기반으로 효과적인 데이터 분석을 위한 가시화 툴 (Tool) 기술이 크게 발전 하였다. 해당 기술 분야는 Visual Analytics (비주얼애널리틱스)라는 연구 분야로 발전하여 2006년 첫 심포지엄이 열린 이래, 다양한 데이터 마이닝 (Data Mining), 상호작용 (Interaction) 기술이 정보 가시화 (Information Visualization) 기술에 접목하여 사용자 중심의 빅 데이터분석 및 의사 결정 시스템을 연구하는 분야로 확장 되었다. 그러나 국내에서는 아직 해당 연구 분야에 대하여 제대로 알려지지 않아, 국내 컴퓨터 그래픽스 및 HCI 기술연구에 비하여, 가시화 기술을 통한 빅데이터 분석 및 의사결정을 지원하는 시스템을 설계하는 기술이 뒤쳐지는 편이다. 따라서 본 논문에서는 비주얼 애널리틱스 연구의 기본 철학을 살펴 보고, IEEE Symposium on Visual Analytics Science and Technology (VAST)학회에 2015년 출판된 논문으로 사용된 데이터 및 가시화 기술 분석 서베이를 진행함으로써 국내 컴퓨터 그래픽스 연구자들의 해당 분야에 대한 이해를 돕고자 한다. As big data become more complex than ever, there has been a need for various techniques and approaches to better analyze and explore such big data. A research discipline of visual analytics has been proposed to help users’ visual data analysis and decision-making. Since 2006 when the first symposium of visual analytics was held, the visual analytics research has become popular as the advanced technology in computer graphics, data mining, and human-computer interaction has been incorporated in visual analytics. In this work we introduce the visual analytics research by reviewing and surveying the papers published in IEEE VAST 2015 in terms of data and visualization techniques to help domestics researchers’ understanding on visual analytics.