http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Neurotoxicity of acrylonitrile evaluated by manganese enhanced magnetic resonance imaging
Ying Li,Lihong Mei,Jinwei Qiang,Chi-Shing Zee,Xiuju Li,Junhua Liu 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.3
Acrylonitrile (ACN), a chemical compound commonly used to manufacture plastics, has been found in drin king water and as a pollutant in the air. Exposure to high levels of ACN leads to brain lesions via oxidative stress-induced injury. To date, there is no non-invasive method of examining brain lesions. We determined if manganese-enhanced magnetic resonance imaging (MEMRI) can be used to detect brain lesions in ACN-treated rats by exploiting the binding properties of manganese to the enzymes manganesesuperoxide dismutase (Mn-SOD) and glutamine synthetase (GS). Rats exposed to low, mid, and high doses of ACN over 7 days were subjected to MEMRI on the eighth day. Contrast enhancement of the brain decreased in ACN-treated rats, along with marked decreases in Mn-SOD and GS activities, particularly in mid- and high-ACN treated rats. Our study indicates that MEMRI may be a potential non-invasive method of detecting ACN-induced oxidative damage.