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Sun Zhiguang,Han Jinsheng,Wang Jindong 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.2
Background Non-small cell lung cancer (NSCLC) is a common malignant tumor with a poor 5-year survival rate. Hypoxia is a common phenomenon that occurs in solid tumors, especially after tumor growth. Circular RNA (circRNA) is aberrantly expressed in NSCLC cells under hypoxia. However, the underlying mechanism of biological function has remained unclear. Objective The purpose of this study is to explore the underlying mechanism of the biological function of Circular RNA PIP5K1A in non-small cell lung cancer. Results The levels of circ-PIP5K1A and 1, 4-alpha-glucan branching enzyme 1 GBE1 (GBE1) were upregulated in NSCLC tissues and NSCLC cells under hypoxia, whereas miR-656-3p was downregulated. Knockdown of circ-PIP5K1A or GBE1 inhibited cell glycolysis, proliferation, and motility while promoting cell apoptosis under hypoxia. Besides, miR-656-3p was a direct target of circ-PIP5K1A, and miR-656-3p could specially bind to GBE1. Moreover, circ-PIP5K1A sponged miR-656-3p to upregulate GBE1 expression. In addition, GBE1 overexpression reversed the inhibitory effect of circ-PIP5K1A knockdown on NSCLC cell malignant phenotype under hypoxia. Conclusion Circ-PIP5K1A could be a tumor promoter in NSCLC and regulated NSCLC cell malignant phenotype under hypoxia through miR-656-3p/GBE1 axis. Background Non-small cell lung cancer (NSCLC) is a common malignant tumor with a poor 5-year survival rate. Hypoxia is a common phenomenon that occurs in solid tumors, especially after tumor growth. Circular RNA (circRNA) is aberrantly expressed in NSCLC cells under hypoxia. However, the underlying mechanism of biological function has remained unclear. Objective The purpose of this study is to explore the underlying mechanism of the biological function of Circular RNA PIP5K1A in non-small cell lung cancer. Results The levels of circ-PIP5K1A and 1, 4-alpha-glucan branching enzyme 1 GBE1 (GBE1) were upregulated in NSCLC tissues and NSCLC cells under hypoxia, whereas miR-656-3p was downregulated. Knockdown of circ-PIP5K1A or GBE1 inhibited cell glycolysis, proliferation, and motility while promoting cell apoptosis under hypoxia. Besides, miR-656-3p was a direct target of circ-PIP5K1A, and miR-656-3p could specially bind to GBE1. Moreover, circ-PIP5K1A sponged miR-656-3p to upregulate GBE1 expression. In addition, GBE1 overexpression reversed the inhibitory effect of circ-PIP5K1A knockdown on NSCLC cell malignant phenotype under hypoxia. Conclusion Circ-PIP5K1A could be a tumor promoter in NSCLC and regulated NSCLC cell malignant phenotype under hypoxia through miR-656-3p/GBE1 axis.
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Selective hydrogenation of phenol for cyclohexanone: A review
Hui Chen,Jinsheng Sun 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.94 No.-
Cyclohexanone from phenol attractively meets the requirements of green chemistry, through catalyticselective hydrogenation, the prevalent methodology in rapid progress recently. In this background,pathways under this methodology are reviewed herein, including possible cyclohexanone formationmechanisms proposed in those years, as well as the corresponding catalysts, such as noble metal, nonnoblemetal and emerging amorphous alloy and heteropoly acids. Among the common catalysts, Pdbasedcatalysts exhibit excellent performance in both conversion and selectivity. Usually, the conversionand selectivity reached almost 100% after the opportune treatment of the metal and support. Othercatalysts such as Pt, Rh, Ni, etc., only perform well in conversion rather than selectivity and the product ismainly cyclohexanol. Amorphous alloys and heteropoly acids, although still relatively rare comparedwith traditional metal catalysts, are bright in prospects indicated by achievements in thisfield. Thereaction mechanism on some catalysts, indistinct to the community, is still in the way of development toovercome the letdown of catalyst design for higher conversion and selectivity industrially. Afterhorizontal comparison of different catalysts, this article manages to give some advice on possiblemethods contributing to the design of efficient and inexpensive catalytic systems.
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Robust Consensus for Networked Mechanical Systems with Coupling Time Delay
Haibo Min,Shicheng Wang,Fuchun Sun,Jinsheng Zhang 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.2
This paper studies the state consensus for a class of networked nonlinear mechanical systems with coupling time delay. In particular, robust consensus protocols for both deterministic and uncertain systems with time delay are investigated. For deterministic systems, we develop a P-like protocol which allows for variable coupling time delay. We show that it is sufficient to have only the relative position information together with a damping control term, whereas the relative velocity information is not needed for state consensus. Then, an adaptive robust control protocol is proposed for uncertain sys-tems with unknown parameters in the system dynamics and arbitrary constant coupling time delays. By introducing the passivity-based framework, we demonstrate that state consensus is still reachable in this case. Finally, a numerical example is included to illustrate the obtained results.
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