Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

Yi Yang,Hong Wang,Ming Zhang,Mengxue Shi,Cailing Yang,Qiang Ni,Qi Wang,Jing Li,Xuemei Wang,Chen Zhang,Zhi Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4

Background: In physical activity or labor, the human body is in a state of high intensity stress, and allparts or physiological functions of the body respond positively to maintain or balance the need formovement. The human body has many physiological changes in the process of movement, and fatigue isthe external manifestation of various complex changes inside the human body. Fatigue is also a physiologicalmechanism of self-protection after the body reaches a certain level of activity, which can preventthe occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complexprocess, and its mechanism has not been concluded yet. Therefore, it is an important work to search andscreen the effective components of natural plants that have anti-fatigue effect and to explore theirmechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110subjects who passed physical examination were included according to the scheme design, and randomlydivided into a test group which was given KRG and a placebo control group. The calculation is carried outaccording to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. AfterKRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acidcontent is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significantlower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful onrelieving physical fatigue.

An Access Control Model for Mobile Networks based on the Non-zero-sum Game Theory

Yi-xuan Zhang,Jing-sha He,Ruo-hong Liu 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.4

Access control is the basic of information security. It is always used to protect sensitive information and critical resources from malicious attacks. But the traditional access control models are more adapt to closed network environment. And there are more and more unknown threats and attacks in the open networks, especially the mobile networks. To solve this problem, we propose a new access control model which is applicable to the open mobile networks by using non-zero-sum game theory in this paper. The model is composed by six modules: access evaluation module, access permission determination module, non-zero-sum game theory analysis module, decision-making module, result evaluation module, access feedback module and a prior information database. And in this model, the subjects will choose to be more honest when they make access requests because they all want to get more permission next time. Then we do some experiments to prove this fact.

ZnO Nanowires/ CdS Nanorods Structure Grown on Silica Micropillars Array for Photosensitive Application

Jing Liu,Yuanze Xu,Xiaoxiao Liang,Mingming Yan,Bo Wang,Tianchong Zhang,Zhen Hong,Futing Yi 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.6

Utilizing silica micropillar arrays as substrate, a kind of Zinc oxide (ZnO) nanowires/Cadmium sulfi de (CdS) nanopillars heterojunctionstructure is prepared successfully by twice hydrothermal reaction method. This ZnO nanowires/CdS nanorods/silicamicropillars structure is tree-liked morphology from the SEM and TEM images, and both the ZnO nanowires and CdS nanorodsare well crystallinity on the silica surface from the X-ray diff raction curves. The CdS nanorods/silica micropillars structure has alow refl ectivity to the incoming light for wavelength from 200 to 800 nm. After the ZnO nanowires growing, the refl ectivity oftree-liked structure is much lower than that without ZnO nanowires especially for the wavelength less than 350 nm. The resistanceresponse of the CdS nanorods/silica micropillars based photoresistors with and without ZnO nanowires are tested. And theresults reveal that the ZnO nanowires covering can improve the response of the CdS nanorods/silica micropillars photoresistors. The best photosensitivity response of the ZnO nanowires/CdS nanorods/silica micropillars photoresistor for 450 nm wavelengthlight with 5 mW/cm 2 illumination can achieve to 23.3, while that for CdS nanorods/silica micropillars photoresistors is 18.8.

Mucin2 is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities

Jing Yi Yu,Xiao Long He,Santhosh Puthiyakunnon,Liang Peng,Yan Li,Li Sha Wu,Wen Ling Peng,Ya Zhang,Jie Gao,Yao Yuan Zhang,Swapna Boddu,Min Long,Hong Cao,Sheng He Huang 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.10

NANOSEEDING EFFECT IN ZSM-5CRYSTALLIZATION PROCESS

YI LU,NAI-QIAN ZHANG,JIN-KU LIU,QIN TONG,DAN-JING HONG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.3

ZSM-5 zeolites were hydrothermally synthesized in three different seeding pathways under the direction of tetrapropylammonium bromide (TPABr) template. In order to investigate the seeding effect in ZSM-5 crystallization process, ZSM-5 crystals and pre-fabricated MFI-type nanoseeds were added into the original self-induction system, respectively. The final ZSM-5 zeolites were systematically investigated based on XRD (X-ray diffraction), SEM (scanning electron micrograph), TEM (transmission electron micrograph), nitrogen adsorption characterizations and NH3-TPD (ammonia-temperature programmed desorption). The self-induction system produced ca. 20 μm ZSM-5 zeolite displaying hexagonally uniform prisms. After the addition of ZSM-5 crystal seeds, the crystal sizes were decreased greatly to ca. 5 μm. When MFI-type nanoseeds were adopted, irregular aggregate particles consisting of 20–50 nm primary particles were rapidly synthesized. The varied hydrothermal crystallization kinetics of the three synthesis system was also explored. Adjusting the seed agents alone, ZSM-5 crystals with diverse structural, morphological, textural and hydrothermal behaviors could be fabricated conveniently. The three ZSM-5 zeolites loaded by 0.05 wt.% Pt were assessed for the xylene isomerization reaction to investigate the particle size effect on the catalytic properties.

중국 본토, 진폐증이 없는 석탄분진 근로자의 '삶의 질'

Yu, Hong-Mei,Ren, Xiao-Wei,Chen, Qian,Zhao, Jing-Yi,Zhu, Ting-Juan,Guo, Zhi-Xi 대한산업보건협회 2009 산업보건 Vol.250 No.-

Protective effect of Insect tea primary leaf (Malus sieboldii (Regal) Rehd.) extract on H2O2‑induced oxidative damage in human embryonic kidney 293T cells

Zhang Jing,Wang Hong,Yi Sha,Guo Zemei,Huang Yue,Li Weifeng,Zhao Xin,Liu Huazhi 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3

In this study, Insect tea primary leaf (Malus sieboldii (Regal) Rehd.) was used as the research object to investigate the protective effect of Insect tea primary extract (ITPLE) on hydrogen peroxide (H2O2)-induced oxidative damage in human embryonic kidney 293T cells (HEK 293T cells) and the mechanism of action of the main active components. The 3-(4,5-dimethyl-2-thiazolyl)- 2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was used to determine the toxicity of ITPLE to HEK 293T cells in vitro as well as its protective effect against (H2O2)-induced oxidative damage in HEK 293T cells. In addition, various assay kits were used to measure oxidation-related indicators in HEK 293T cells, and quantitative polymerase chain reaction (qPCR) analysis was used to determine the mRNA expression levels of oxidation-related genes in HEK 293T cells. High performance liquid chromatography (HPLC) analysis was used to characterize active components in ITPLE. The experimental results revealed that the ITPLE had no toxic effect on cells in the range of 0–200 μg/mL, and, in this range, exhibited a concentration-dependent protective effect against H2O2- induced oxidative damage in HEK 293T cells. It was also found that the ITPLE can reduce the malondialdehyde (MDA) level and increase the levels of superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px), and catalase (CAT)in oxidative damage HEK 293T cells. The qPCR analysis results also showed that the ITPLE upregulated the mRNA expression levels of SOD, CAT , GSH and GSH-Px in HEK 293T cells damaged by H2O2- induced oxidative stress. The HPLC analysis identified 7 bioactive components in the ITPLE, including neochlorogenic acid, cryptochlorogenic acid, rutin, kaempferin, isochlorogenic acid B, isochlorogenic acid A and hesperidin. This study reveals that ITPLE is rich in active compounds and has good antioxidant effect in vitro, thus it has the potential to be developed into a traditional Chinese medicine and functional drinks.

Application of harmonic radar to analyze dispersal behavior of the Japanese pine sawyer beetle, Monochamus alternatus (Coleoptera Cerambycidae)

Zi-Yi ZHANG,Yu-Ping ZHA,San-ShanCAI,Cheng-Hao HONG,Peng Liang,Jing-Yuan CHEN 한국곤충학회 2020 Entomological Research Vol.50 No.1

Monochamus alternatus (Hope) is a severe wood-boring pest in coniferous forests and a major vector of pine wilt disease in East Asia. Harmonic radar is a powerful tool for studying the dispersal behavior of insects and it could be applied to control pine wilt disease. In this study, we validated the application of harmonic radar for analyzing the dispersal behavior of M. alternatus beetles in a field environment. We determined the wing capacities of the beetles and the effects of electronic tagging and marking on their movement, flight ability, survivorship, and food consumption in the laboratory to confirm the suitability of this technique. The detection rate and recovery rate for beetles were analyzed separately using radar on caged pine stands and in the field environment. The results showed that the minimum wing capacity of the Japanese pine sawyer was 24.9 mg, which was seven times the weight of the electronic tag (3.5 mg). Marking and tagging the beetles had no significant adverse effects on their movement, flight capacity, food consumption, and survivorship. The detection rate using the radar system and recovery rate based on visual observations of the beetles in caged pines were both 95.6%. However, in the field environment, the detection and recovery rates were only 55.6% and 37.8% after one week, respectively, and 33.3% and 7.8% after two weeks. Harmonic radar is a promising technique for studying the dispersal behavior of the Japanese pine sawyer, but its performance is not satisfactory and major improvements are required for both the radar system and electronic tags.

Baicalin Induces Apoptosis in Leukemia HL-60/ADR Cells via Possible Down-regulation of the PI3K/Akt Signaling Pathway

Zheng, Jing,Hu, Jian-Da,Chen, Ying-Yu,Chen, Bu-Yuan,Huang, Yi,Zheng, Zhi Hong,Liu, Ting-Bo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background: The effect and possible mechanism of traditional Chinese medicine, baicalin, on the PI3K/Akt signaling pathway in drug-resistant human myeloid leukemia HL-60/ADR cells have been investigated in this current study. Methods: HL-60/ADR cells were treated by 20, 40, $80\;{\mu}mol/L$ baicalin followed by cell cycle analysis at 24h. The mRNA expression level of the apoptosis related gene, Bcl-2 and bad, were measured by RT-PCR on cells treated with $80\;{\mu}mol/L$ baicalin at 12, 24 and 48hr. Western blot was performed to detect the changes in the expression of the proteins related to HL-60/ADR cell apoptosis and the signaling pathway before and after baicalin treatment, including Bcl-2, PARP, Bad, Caspase 3, Akt, p-Akt, NF-${\kappa}B$, p-NF-${\kappa}B$, mTOR and p-mTOR. Results: Sub-G1 peak of HL-60/ADR cells appeared 24 h after $20\;{\mu}mol/L$ baicalin treatment, and the ratio increased as baicalin concentration increased. Cell cycle analysis showed 44.9% G0/G1 phase cells 24 h after baicalin treatment compared to 39.6% in the control group. Cells treated with $80\;{\mu}mol/L$ baicalin displayed a trend in decreasing of Bcl-2 mRNA expression over time. Expression level of the Bcl-2 and PARP proteins decreased significantly while that of the PARP, Caspase-3, and Bad proteins gradually increased. No significant difference in Akt expression was observed between treated and the control groups. However, the expression levels of p-Akt, NF-${\kappa}B$, p-NF-${\kappa}B$, mTOR and p-mTOR decreased significantly in a time-dependent manner. Conclusions: We conclude that baicalin may induce HL-60/ADR cell apoptosis through the PI3K/AKT signaling pathway.

Digital Native 척도 개발 및 검증

홍민지(Minji Hong),우선연(Sunyeon Woo),진징(Jin Jing),센이(Shen Yi),이재학(Jeahak Lee),박철(Cheol Park) 한국IT서비스학회 2010 한국IT서비스학회 학술대회 논문집 Vol.2010 No.9

본 연구는 Don Tapscott(2008)의 디지털 네이티브(Digital Native)의 8가지 특성인 자유, 맞춤제작, 철저한 조사, 성실성, 협업, 엔터테인먼트, 속도, 혁신에 대한 척도를 개발하여, 한국과 중국의 젊은 세대들을 대상으로 검증해 보았다. 설문은 한국, 중국의 10대~30대, 남녀 506명이 응답하였으며, 수집된 설문지를 통해 디지털 네이티브의 8가지 차원을 확인하였으며, 측정의 신뢰도와 타당성을 검증하였다. 또한 한국과 중국의 디지털 네이티브 성향 차이를 살펴보고 IT소비 상관관계에 대해 알아보았다. 그 결과 디지털 네이티브(Digital Native)의 8가지 요인은 IT 소비와 유의한 상관관계를 나타내었으며, 특히 엔터테인먼트, 자유, 혁신속성에서 비교적 높은 상관관계가 있는 것으로 나타났다. 또한 디지털 네이티브 성향이 높은 집단과 낮은 집단 간에는 IT 소비면에서 거의 모두 유의한 차이가 나타났다. 본 연구결과는 한국과 중국의 디지털 네이티브(Digital Native) 세대의 새로운 소비특징과 소통 방법을 연구하여 그들에게 맞는 새로운 마케팅 방향을 제시할 수 있을 것이다.