Experimental investigations on detecting lateral buckling for subsea pipelines with distributed fiber optic sensors

Jing Zhou,Xin Feng,Wenjing Wu,Xingyu Li,Xiaowei Zhang 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.2

A methodology based on distributed fiber optic sensors is proposed to detect the lateral buckling for subsea pipelines in this study. Uncontrolled buckling may lead to serious consequences for the structural integrity of a pipeline. A simple solution to this problem is to control the formation of lateral buckles among the pipeline. This firms the importance of monitoring the occurrence and evolution of pipeline buckling during the installation stage and long-term service cycle. This study reports the experimental investigations on a method for distributed detection of lateral buckling in subsea pipelines with Brillouin fiber optic sensor. The sensing scheme possesses the capability for monitoring the pipeline over the entire structure. The longitudinal strains are monitored by mounting the Brillouin optical time domain analysis (BOTDA) distributed sensors on the outer surface of the pipeline. Then the bending-induced strain is extracted to detect the occurrence and evolution of lateral buckling. Feasibility of the method was validated by using an experimental program on a small scale model pipe. The results demonstrate that the proposed approach is able to detect, in a distributed manner, the onset and progress of lateral buckling in pipelines. The methodology developed in this study provides a promising tool for assessing the structural integrity of subsea pipelines

Anti-obesity Effect of Whole Body Vibration Exercise : A Clinical Pilot Trial

Ailyn Fadriquela,Johny Bajgai,Rahima Begum,Jing Xingyu,Cheol Su Kim,Soo-Ki Kim,Dong Heui Kim,Kyu-Jae Lee 한국물학회 2019 한국물학회지 Vol.7 No.1

It is well known that exercise is effective in overcoming obesity. Recent studies have focused on various types of exercise in which vibration exercise was involved. In this study, we investigated the effect of whole body vibration (WBV) exercise using the bed-type vibrator through pre-post data analysis. Twenty participants were carefully recruited and were treated on a vibrating bed with an automatic program developed by integration of 1-8 steps for 1 hr maintaining the 40°C of bed temperature. Blood pressure, body mass indices (BMI), hematological indices, oxidative stress-related markers, cytokines, and obesity-related biomarkers such as adiponectin, resistin and irisin were measured. Results showed that diastolic blood pressure was significantly lowered after 1 hr of WBV treatment (p < 0.05). In lipid tests, total cholesterol and low-density lipoprotein cholesterol were decreased (p < 0.01, respectively). Oxidative stress-related markers such as reactive oxygen species (p < 0.05), nitric oxide (p < 0.05) and glutathione peroxidase (p < 0.01) were significantly increased. Interleukin (IL)-10, and tumor necrosis factor-α were significantly decreased and IL-6 and interferon (INF)-γ also showed decreasing trend. Adiponectin involved in insulin sensitivity was increased and resistin involved in insulin resistance decreased, but there were no significance. In addition, irisin levels were significantly decreased after the WBV exercise. In conclusion, the bed-type of WBV exercise reduced the blood pressure and cholesterol, and showed favorable response to obesity biomarkers. Also, oxidative stress level was increased but relatively stable and not severe, and inflammation and allergic reaction were not observed. Thus, the application of bed-type WBV exercise can be a safe and effective alternative for the improvement of obesity.

Experimental investigations on detecting lateral buckling for subsea pipelines with distributed fiber optic sensors

Feng, Xin,Wu, Wenjing,Li, Xingyu,Zhang, Xiaowei,Zhou, Jing Techno-Press 2015 Smart Structures and Systems, An International Jou Vol.15 No.2

A methodology based on distributed fiber optic sensors is proposed to detect the lateral buckling for subsea pipelines in this study. Uncontrolled buckling may lead to serious consequences for the structural integrity of a pipeline. A simple solution to this problem is to control the formation of lateral buckles among the pipeline. This firms the importance of monitoring the occurrence and evolution of pipeline buckling during the installation stage and long-term service cycle. This study reports the experimental investigations on a method for distributed detection of lateral buckling in subsea pipelines with Brillouin fiber optic sensor. The sensing scheme possesses the capability for monitoring the pipeline over the entire structure. The longitudinal strains are monitored by mounting the Brillouin optical time domain analysis (BOTDA) distributed sensors on the outer surface of the pipeline. Then the bending-induced strain is extracted to detect the occurrence and evolution of lateral buckling. Feasibility of the method was validated by using an experimental program on a small scale model pipe. The results demonstrate that the proposed approach is able to detect, in a distributed manner, the onset and progress of lateral buckling in pipelines. The methodology developed in this study provides a promising tool for assessing the structural integrity of subsea pipelines.

Effect of the Mineral Complex Treatment on Atopic Dermatitis like-Lesion in 2, 4-Dinitrochlorobenzene Induced in Hairless Mice

Johny Bajgai,Cheol-Su Kim,Ailyn Fadriquela,Rahima Begum,Xingyu Jing,Dong Heui Kim,Soo-Ki Kim,Kyu-Jae Lee 한국물학회 2019 한국물학회지 Vol.7 No.1

Atopic dermatitis (AD) is chronic relapsing skin inflammatory allergic disease characterized by a complex pathogenesis including skin barrier dysfunction, immune-redox disturbances and pruritus. Topical treatment medications such as corticosteroids, calcineurin inhibitors, T-cell inhibitors were used in AD but these agents may have some potential side-effects. Therefore, many researchers explored abundant numbers of alternative therapies by using natural products and mineral compounds related with its antioxidant and immunomodulator effects to minimize toxicity and adverse-effects. In the present study, we investigated the effects of mineral complex material patch (MCM) treatment on AD-like lesions in 2, 4-dinitrochlorobenzene (DNCB)-induced hairless mice. Animals were divided into four groups; normal control, negative control (DNCB Only), DNCB+ Tacrolimus (PC) and DNCB+MCM patch to evaluate its therapeutic effect on DNCB-induced AD. Our results showed that MCM patch improved the skin dermatitis by significantly increasing the skin barrier strength, score and moisture level and decreasing the transepidermal water loss as compared to DNCB only group. In line, ROS level, inflammatory, Th1 and Th2 cytokines were decreased with MCM treatment whereas nitric oxide level and total anti-oxidant enzyme activities were significantly enhanced as compared to DNCB only and NC groups. Moreover, total IgE level was significantly increased in DNCB only group and decreased in PC and MCM treated group. Taken together, our findings suggest that MCM may potentially protect against AD lesional skin via regulation of skin barrier function and immune-redox response. However, further studies are needed to explain the detail molecular mechanism of MCM effect.

Molecular hydrogen protects against oxidative stress‑induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway

Rahima Begum,Cheol‑Su Kim,Ailyn Fadriquela,Johny Bajgai,Xingyu Jing,Dong‑Heui Kim,Soo‑Ki Kim,Kyu‑Jae Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2

Background Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases. Objective In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2- induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway. Results Our results showed H2 increased the macrophage cell proliferation and generated ROS and NO against LPS stimulation to exert an active immune response. Similarly, H2 protected the macrophage cell from H2O2- induced oxidative stress. H2 reduced the LPS-and H2O2- induced inflammatory cytokine production and intracellular calcium influxes. H2 inhibited the LPS-and H2O2- induced phosphorylation of MAPK pathway and its downstream signaling molecules. Furthermore, H2 protected the macrophage cell from mitochondrial apoptosis. H2 increased Nrf2 protein expression indicating its strong anti-oxidative effects against oxidative stress. Conclusion Collectively, our results indicate the strong antioxidant role of H2 against LPS-and H2O2- induced oxidative stress on macrophage cells by activating the Nrf2 pathway and inhibiting the MAPK-signaling pathway.

Gestational weight gain of multiparas and risk of primary preeclampsia: a retrospective cohort study in Shanghai

Chen Chao,Lei Zhijun,Xiong Yaoxi,Ni Meng,He Biwei,Gao Jing,Zheng Panchan,Xie Xianjing,He Chengrong,Yang Xingyu,Cheng Weiwei 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-

Background In all studies conducted so far, there was no report about the correlation between excessive gestational weight gain (GWG) and the risk of preeclampsia (PE) in multiparas, especially considering that multiparity is a protective factor for both excessive GWG and PE. Thus, the aim of this retrospective cohort study was to determine whether GWG of multiparas is associated with the increased risk of PE. Methods This was a study with 15,541 multiparous women who delivered in a maternity hospital in Shanghai from 2017 to 2021, stratifed by early-pregnancy body mass index (BMI) category. Early-pregnancy body weight, height, week-specifc and total gestational weight gain as well as records of antenatal care were extracted using electronic medical records, and antenatal weight gain measurements were standardized into gestational age-specifc z scores. Results Among these 15,541 multiparous women, 534 (3.44%) developed preeclampsia. The odds of preeclampsia increased by 26% with every 1 z score increase in pregnancy weight gain among normal weight women and by 41% among overweight or obese women. For normal weight women, pregnant women with preeclampsia gained more weight than pregnant women without preeclampsia beginning at 25 weeks of gestation, while accelerated weight gain was more obvious in overweight or obese women after 25 weeks of gestation. Conclusions In conclusion, excessive GWG in normal weight and overweight or obese multiparas was strongly associated with the increased risk of preeclampsia. In parallel, the appropriate management and control of weight gain, especially in the second and third trimesters, may lower the risk of developing preeclampsia.

감성인식에서 기존 동공 변수는 유효한가?

목수빈(Subin Mok),이현우(Hyunwoo Lee),유서희(Suhhee Yoo),조아영(Ayoung Cho),장징(Jing Zhang),온성옥(Xingyu Wen),황민철(Mincheol Whang) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2

동공은 빛의 밝기, 인지적, 감성에 의한 영향을 받으며 자율 신경계와 연관이 있는 곳이다. 그래서 시각적 자극으로 유발하는 감성에 의해 동공 크기가 극적으로 나타날 수 있고, 인지적 부하 또는 인지적 판단을 필요로 하는 감성으로 인한 동공 크기 변화는 그 정도가 작을 수 있다. 즉, 자극의 종류가 결과에 영향을 미칠 수 있다는 것이다. 본 연구는 기존연구에서 사용된 변수를 오픈 데이터인 MAHNOBHCI(Soleymani, M., et al,. (2011).) 데이터 셋을 통해 검증하고자 하였다. 통계 분석 결과, 유의확률(p<0.01)을 만족하고, 문헌조사와 결과가 일치하는 변수는 동공 크기, 동공 크기 변화율, 최대 팽창 시간이다. 특히 동공 크기, 동공 크기 변화율은 좌안과 우안에 상관없이 Arousal, Valence 감성구분에 유효한 결과를 보였다.